Paxotus Plus 25 Mg Capsule 10
10 Capsule(s) in StripWe do not sell this product
Made by
EMCURE PHARMACEUTICALS LTD
Dosage
CAPSULE
Expiry
Product Summary
| Salt Content | Paroxetine(25.0 Mg)+Clonazepam(0.5 Mg) |
| Therapy | Anti-depressant |
Assurance
available
Regulated
Medical Description
Paxotus Plus is a prescription medication. It contains a combination of Clonazepam and Paroxetine as its active ingredients. It is used for the management of depression and anxiety.
Depression is a mental health disorder that causes a person to feel excessively sad, angry, and unmotivated. Anxiety is a condition in which a person may experience persistent feelings of fear, dread, worry, and uneasiness about everyday situations. These disorders may lead to a decrease in quality of life.
It is essential to only take the Paxotus Plus tablet on prescription by a doctor, at the exact dose and for the entire duration prescribed.
Uses
- For comorbid depression and anxiety disorder
Contraindications
- Patients with spinal or cerebellar ataxia (abnormal muscle movements that may cause inability to walk).
- Patients with myasthenia gravis (a severe form of muscle weakness).
- Patients with impaired liver, lung, or kidney function.
- Patients suffering from sleep apnoea (a condition associated with difficulty in breathing while asleep and snoring).
- Patients who have an alcohol dependence disorder.
- Patients with suicidal tendencies.
- Patients with acute narrow-angle glaucoma (elevated pressure in the eye).
- Patients with a known hypersensitivity to Clonazepam and Paroxetine.
Side effects
- Nausea
- Vomiting
- Gastric discomfort
- Loss of appetite
- Increased irritability
- Diarrhea
- Anxiety
- Delayed Ejaculation/Erectile dysfunction
- Loss of sexual drive
- Tremors
- Sleepiness
- Uncoordinated body movements
- Dizziness
- Bleeding
- Increased suicidal thinking or behaviour is seen in a few patients
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You suffer from any health problems, including glaucoma, seizures, heart conditions, renal disorders, or liver conditions.
- You develop any thoughts of harming yourself while on the Paxotus Plus tablet.
- You are on any other medications.
Directions for Use
- It is recommended that the Paxotus Plus tablet be taken at fixed times every day, preferably at night.
- Paxotus Plus tablet can be taken with or without food.
- Swallow the tablet whole, do not split, crush, or chew.
- Take the Paxotus Plus tablet at the recommended dose. Do not alter the dose in any way, as this may lead to undesirable side effects.
- It is essential to take the Paxotus Plus tablet for the entire duration prescribed to you by your doctor. Abruptly stopping the Paxotus Plus tablet can lead to side effects such as increased irritability, difficulty sleeping, nausea, or anxiety.
Storage and disposal
Store the Paxotus Plus tablet in a cool and dry place. Avoid exposure to direct sunlight.
Dosage
Overdose
An overdose of Paxotus Plus tablets can lead to many serious side effects. The most common symptoms are nausea, vomiting, diarrhoea, convulsions, dizziness, and somnolence, which may progress to coma and respiratory difficulties. Immediately seek medical care at a tertiary centre in cases of an overdose.
Missed a Dose
In case of a missed dose, take it as soon as you remember. However, if this time is closer to the time of your next scheduled dose, skip the missed dose and continue with your regular scheduled dose. Do not double the dose of the Paxotus Plus tablet.
Mode of Action
How Does It Work?
The pharmacological component of Paxotus Plus is a combination of medications called Clonazepam and Paroxetine. One of the main causes of depression is a decrease in the amount of a chemical known as Serotonin in the brain. Paroxetine is a selective serotonin-reuptake inhibitor, which enhances the activity of the available serotonin in the brain. This, in turn, will reduce the symptoms of depression and anxiety.
Clonazepam is a derivative of a group of medications called benzodiazepines. It acts by increasing the activity of a certain chemical in the brain called GABA (gamma-amino-butyric acid). GABA is an inhibitory neurotransmitter. It is a chemical that sends suppressing signals to the nerves in the part of the body in which it is secreted. In people suffering from anxiety and depression, there is an excessive and abnormal activity of nerve cells in the brain. This activity can be suppressed by increasing the activity of GABA in the brain.
Interactions
Interactions with other medicines
- Co-administration of Tranylcypromine or any other monoamine oxidase (MAO) inhibitors, as the risk or severity of adverse effects can be increased. Taking them within 14 days of treatment is also contraindicated.
- Co-administration with Tapentadol or other medications that increase the level of serotonin is not recommended, as lt may increase the central nervous system depressant effects of the medicine and may precipitate a dangerous side effect called Serotonin Syndrome.
- Co-administration with other benzodiazepines and strong painkillers like Tramadol is not recommended as it can potentiate its actions.
- Co-administration with warfarin, NSAIDs (Nonsteroidal anti-inflammatory medicines), aspirin, or other medicines affecting coagulation is not recommended as this may lead to an increased risk of bleeding.
- The metabolism of Clonazepam and Paroxetine may be decreased with certain medicines. This may lead to their actions being prolonged. Co-administration of these medicines, including Cimetidine, Amoxicillin, etc., is not recommended.
- The metabolism of Clonazepam and Paroxetine may be increased with certain medicines. This may lead to a decrease in its efficacy. Co-administration of these medicines, including rifampicin, linezolid, etc., is not recommended.
Frequently Asked Questions (FAQs)
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Manufacturer Details
Brand:PAXOTUS PLUS
Vendor Details
Fulfillment Information: Paxotus Plus 25 Mg Capsule 10 will be delivered by a licensed retail pharmacy nearest to your location. Order acceptance and fulfillment are dependent upon the verification of your doctor's valid prescription (where applicable) and the current stock of this medicine.
References:
- Paroxetine: Uses, Interactions, Mechanism of Action | DrugBank Online [Internet]. Go.drugbank.com. [cited 16 March 2022].
- [Internet]. Accessdata.fda.gov. [cited 16 March 2022].
- Clonazepam: Uses, Interactions, Mechanism of Action | DrugBank Online [Internet]. Go.drugbank.com. [cited 16 March 2022].
- Clonazepam: medicine to control seizures or fits, muscle spasms and restless legs syndrome [Internet]. nhs.uk. [cited 16 March 2022].
- [Internet]. Accessdata.fda.gov. [cited 16 March 2022].
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The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.
