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Nildep 25mg Tablet

10 Tablet(s) in Strip
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Nildep 25 MG Description

Nildep 25 tablet is a prescription medication. It is an antidepressant used primarily to treat the symptoms of major depressive disorder. In addition to treating depression, this medicine is also use

d for the temporary management of nocturnal enuresis (night bedwetting) in children. The active component of Nildep 25 mg tablets is Imipramine (25 mg). It belongs to a class of medications called tricyclic antidepressants. Depression is a debilitating mental health disorder characterised by pervasive low moods, decreased motivation, feelings of hopelessness and dread, and loss of interest in daily activities. Multiple brain pathways and chemical messengers are affected in depression, chiefly serotonin, norepinephrine and dopamine. The mode of action of Nildep 25 tablets is by targeting these pathways and neurotransmitters to help relieve the symptoms of depression. Directions for use of Nildep 25 tablets should be strictly followed. It should be taken exactly as recommended by the doctor. It should not be abruptly started or stopped, as it may cause a relapse of symptoms, withdrawal symptoms, and worsening of the underlying condition. Side effects of Nildep 25 tablets include weight gain, constipation, dry mouth, dizziness, headache, sleepiness, urinary retention, orthostatic hypotension (sudden lowering of blood pressure on standing up), increased heart rate, heart rhythm abnormalities, dizziness, blurred vision, and confusion.


Product Summary

Offer Price₹22.19
You Save₹3.92 (15% on MRP)
ContainsImipramine(25.0 Mg)
UsesMajor depressive disorder, Temporary management of nocturnal enuresis
Side effectsConstipation, Urinary retention, Weight gain, Confusion, Orthostatic hypotension (sudden lowering of blood pressure on standing), Tiredness, Blurred vision, Dry mouth, Confusion, Delirium, Dizziness, Seizures
Check more medicines with composition as Imipramine(25.0 Mg)

Uses of Nildep 25 MG

  • Nildep 25 tablets are used in the treatment of:
  • Major Depressive Disorder
  • Temporary management of nocturnal enuresis (night bedwetting) in children

Contraindications of Nildep 25 MG

  • Do not take Nildep 25 tablet or use caution:
  • If you have hypersensitivity to the active or inactive ingredients of this medicine
  • If you have a history of heart conditions, such as irregular heart rhythm or myocardial infarction (heart attack)
  • If you are diagnosed with angle-closure glaucoma, prostate enlargement, liver disease, and urinary retention. This medicine is contraindicated.
  • If you are diagnosed with porphyrias (a blood disorder); this medication should be avoided.
  • If you have a history of bipolar disorder, mania, or a family history of mania. This medicine is contraindicated.
  • If you are a child under six. Nildep 25 tablet is not meant for use in children.
  • If you are an adolescent or young adult under 24. Use extreme caution as Nildep 25 tablets may increase suicidal ideation in this age group.

Side effects of Nildep 25 MG

  • Side effects of Nildep 25 tablets include:
  • Weight gain
  • Constipation
  • Dry mouth
  • Dizziness
  • Headache
  • Somnolence (sleepiness)
  • Urinary retention
  • Orthostatic hypotension (sudden lowering of blood pressure on standing up)
  • Increased heart rate (tachycardia)
  • Heart rhythm abnormalities
  • Dizziness
  • Blurred vision
  • Confusion
  • Delirium
  • Seizures

Precautions and Warnings of Nildep 25 MG



Can I take Nildep 25 tablets during pregnancy?
No. Imipramine is a category-C medication and unsafe in pregnancy. Do not take Nildep 25 tablets if you are pregnant or planning to conceive. Please consult your doctor and inform them of your health status.

Breast Feeding

Can I take Nildep 25 tablets while breastfeeding?
This medication is generally not advised while breastfeeding. Discuss your breastfeeding status with your doctor for more information.


Can I drive if I have taken a Nildep 25 tablet?
Driving and operating other heavy machinery while on treatment with Nildep 25 tablet is not recommended, as this medicine can cause sedation and drowsiness.


Can I consume alcohol with Nildep 25 tablets?
Alcohol consumption while on treatment with Nildep 25 tablets is contraindicated. Mixing alcohol with this medicine may cause increased sedation and other adverse effects.

Other General Warnings

Talk to your doctor if
  • You take other medications for your health.
  • You experience any discomfort or sudden mood changes.

Mode of Action of Nildep 25 MG

How Does It Work?

Imipramine belongs to a class of medications called Tricyclic antidepressants (TCAs) that act on multiple brain pathways to increase levels of certain chemical messengers called neurotransmitters. It ...
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Directions for Use of Nildep 25 MG

  • Take Nildep 25 tablets exactly as advised by your doctor.
  • Do not exceed the dosage, even if you cannot notice the effects of this medicine.
  • Nildep 25 tablets require 2-4 weeks for onset of action. Do not increase the dose without explicit advice from your treating physician.
  • Take Nildep 25 tablets as a whole with a glass of water.
  • Do not break or chew this tablet.
  • Take Nildep 25 tablets at the same time every day, so a stable level of the medication is maintained in the body. Do not take Nildep 25 tablets with other medicines without informing your doctor.
  • Do not consume this medicine if its packaging is broken.
  • Do not abruptly stop taking Nildep 25 tablets; this can result in adverse effects from withdrawal.

Interactions of Nildep 25 MG

Interactions with other medicines

  • Nildep 25 tablets can interact with many medicines and cause adverse side effects. It is advised to inform the doctor of all medication being taken to be checked for possible interaction issues. The f...
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  • Concomitant use of monoamine oxidase inhibitors (MAOIs) or within 14 days of MAOIs use is not advised. Examples of MAOIs include selegiline and rasagiline.
  • Nildep 25 tablets with other medication, like isocarboxazid, that increase serotonin levels can be fatal.
  • Do not use Nildep 25 tablets with medicines that decrease the seizure threshold.
  • Do not use Nildep 25 tablets with other CNS depressants.
  • Nildep 25 tablets should not be mixed with opioid medications or benzodiazepines.
  • Nildep 25 tablets affect heart rhythm and should not be used in addition to other medicine (like astemizole and cisapride) with the same effect. This can lead to life-threatening conditions.
  • This medication can potentiate the effect of anticoagulants, resulting in bleeding manifestations.
  • Concomitant use with beta-blockers can increase the blood concentrations of imipramine and increase side effects.

Storage and disposal of Nildep 25 MG

Store Nildep 25 tablets at room temperature, away from wet surfaces, direct sunlight, and humidity. Keep away from children and pets. Check the expiration date before taking the tablets. Dispose of th...
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Dosage of Nildep 25 MG


Imipramine toxicity can be serious and even fatal. In an overdose, the affected person may present with sedation, seizure, coma, increased heart rate, low blood pressure, dilated pupils, dry mouth, an...
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Missed a Dose

If you have missed a dose of Nildep 25 tablet, try to take it as soon as you remember. If you recall the missed dose when it is almost time for the next one, skip the missed one and continue with your...
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Content Details


Dr. Bhavika Shah

MBBS, MD (Dermatology), DNB (Dermatology)

Frequently Asked Questions (FAQs)


Q: I have been using Nildep 25 tablets for a month now and feel better. Can I stop taking it?

A: Sudden stoppage of the medicine can significantly cause a higher risk of your symptoms returning and producing withdrawal symptoms. If you want to stop taking Nildep 25 tablets, your doctor will slowly taper the dose before stopping it completely.

Q: I have been using Nildep 25 tablets for a few days but feel no change. What should I do?

A: Nildep requires 2-4 weeks for the effects of the medication to take effect properly. Take the tablets as directed by your treating physician. It is important to review routinely for appropriate dose adjustment. Talk to your doctor for more information.

Q: I have felt very hungry ever since I started this medication. My weight has also increased. Should I stop the tablet?

A: Weight gain and increased appetite are common side effects of Nildep 25 tablets. Your doctor can guide you on how to manage these symptoms. Please continue taking the pill as advised until you consult your doctor.
Product Details
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Last Updated on: 14 Apr 2022 | 03:15 PM (IST)
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