Nildep 25mg Tablet
10 Tablet(s) in StripWe do not sell this product
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Dosage
TABLET
Expiry
Product Summary
| Salt Content | Imipramine(25.0 Mg) |
| Uses | Major depressive disorder, Temporary management of nocturnal enuresis |
| Therapy | Anti-depressant |
| Side effects | Constipation, Urinary retention, Weight gain, Confusion, Orthostatic hypotension (sudden lowering of blood pressure on standing), Tiredness, Blurred vision, Dry mouth, Confusion, Delirium, Dizziness, Seizures |
Assurance
available
Regulated
Medical Description
Nildep 25 tablet is a prescription medication. It is an antidepressant used primarily to treat the symptoms of major depressive disorder. In addition to treating depression, this medicine is also used for the temporary management of nocturnal enuresis (night bedwetting) in children. The active component of Nildep 25 mg tablets is Imipramine (25 mg). It belongs to a class of medications called tricyclic antidepressants.
Depression is a debilitating mental health disorder characterised by pervasive low moods, decreased motivation, feelings of hopelessness and dread, and loss of interest in daily activities. Multiple brain pathways and chemical messengers are affected in depression, chiefly serotonin, norepinephrine and dopamine. The mode of action of Nildep 25 tablets is by targeting these pathways and neurotransmitters to help relieve the symptoms of depression.
Directions for use of Nildep 25 tablets should be strictly followed. It should be taken exactly as recommended by the doctor. It should not be abruptly started or stopped, as it may cause a relapse of symptoms, withdrawal symptoms, and worsening of the underlying condition.
Side effects of Nildep 25 tablets include weight gain, constipation, dry mouth, dizziness, headache, sleepiness, urinary retention, orthostatic hypotension (sudden lowering of blood pressure on standing up), increased heart rate, heart rhythm abnormalities, dizziness, blurred vision, and confusion.
Uses
- Nildep 25 tablets are used in the treatment of:
- Major Depressive Disorder
- Temporary management of nocturnal enuresis (night bedwetting) in children
Contraindications
- Do not take Nildep 25 tablet or use caution:
- If you have hypersensitivity to the active or inactive ingredients of this medicine
- If you have a history of heart conditions, such as irregular heart rhythm or myocardial infarction (heart attack)
- If you are diagnosed with angle-closure glaucoma, prostate enlargement, liver disease, and urinary retention. This medicine is contraindicated.
- If you are diagnosed with porphyrias (a blood disorder); this medication should be avoided.
- If you have a history of bipolar disorder, mania, or a family history of mania. This medicine is contraindicated.
- If you are a child under six. Nildep 25 tablet is not meant for use in children.
- If you are an adolescent or young adult under 24. Use extreme caution as Nildep 25 tablets may increase suicidal ideation in this age group.
Side effects
- Side effects of Nildep 25 tablets include:
- Weight gain
- Constipation
- Dry mouth
- Dizziness
- Headache
- Somnolence (sleepiness)
- Urinary retention
- Orthostatic hypotension (sudden lowering of blood pressure on standing up)
- Increased heart rate (tachycardia)
- Heart rhythm abnormalities
- Dizziness
- Blurred vision
- Confusion
- Delirium
- Seizures
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You take other medications for your health.
- You experience any discomfort or sudden mood changes.
Directions for Use
- Take Nildep 25 tablets exactly as advised by your doctor.
- Do not exceed the dosage, even if you cannot notice the effects of this medicine.
- Nildep 25 tablets require 2-4 weeks for onset of action. Do not increase the dose without explicit advice from your treating physician.
- Take Nildep 25 tablets as a whole with a glass of water.
- Do not break or chew this tablet.
- Take Nildep 25 tablets at the same time every day, so a stable level of the medication is maintained in the body. Do not take Nildep 25 tablets with other medicines without informing your doctor.
- Do not consume this medicine if its packaging is broken.
- Do not abruptly stop taking Nildep 25 tablets; this can result in adverse effects from withdrawal.
Storage and disposal
Store Nildep 25 tablets at room temperature, away from wet surfaces, direct sunlight, and humidity. Keep away from children and pets. Check the expiration date before taking the tablets. Dispose of the packaging carefully after use. Do not flush extra or expired pills down the toilet. Dispose of unused or expired medicine as biomedical waste.
Dosage
Overdose
Imipramine toxicity can be serious and even fatal. In an overdose, the affected person may present with sedation, seizure, coma, increased heart rate, low blood pressure, dilated pupils, dry mouth, and have difficulty passing urine or stools, abnormal heart rhythms, and low urine output. If you overdose on Nildep 25 tablets and experience these symptoms, immediately seek emergency medical treatment from a nearby hospital.
Missed a Dose
If you have missed a dose of Nildep 25 tablet, try to take it as soon as you remember. If you recall the missed dose when it is almost time for the next one, skip the missed one and continue with your regular dosing schedule. Do not take both of them together; this can lead to adverse reactions.
Mode of Action
How Does It Work?
Imipramine belongs to a class of medications called Tricyclic antidepressants (TCAs) that act on multiple brain pathways to increase levels of certain chemical messengers called neurotransmitters. It works by increasing the neurotransmitters serotonin and norepinephrine levels that affect mood and personality. In the long term, it increases the levels of BDNF (brain-derived neurotrophic factor). This reduces the symptoms of Major Depressive Disorder. In addition to serotonin and norepinephrine, imipramine also acts on multiple other brain pathways involving dopamine, histamine, acetylcholine, and epinephrine. It is important to note that the Nildep 25 tablet as an antidepressant requires about 2-4 weeks of continued use for the optimal onset of action.
In nocturnal enuresis, imipramine is thought to act by decreasing the stage of sleep during which wetting occurs.
Interactions
Interactions with other medicines
- Nildep 25 tablets can interact with many medicines and cause adverse side effects. It is advised to inform the doctor of all medication being taken to be checked for possible interaction issues. The following medicines are known to interact with Nildep 25 tablets.
- Concomitant use of monoamine oxidase inhibitors (MAOIs) or within 14 days of MAOIs use is not advised. Examples of MAOIs include selegiline and rasagiline.
- Nildep 25 tablets with other medication, like isocarboxazid, that increase serotonin levels can be fatal.
- Do not use Nildep 25 tablets with medicines that decrease the seizure threshold.
- Do not use Nildep 25 tablets with other CNS depressants.
- Nildep 25 tablets should not be mixed with opioid medications or benzodiazepines.
- Nildep 25 tablets affect heart rhythm and should not be used in addition to other medicine (like astemizole and cisapride) with the same effect. This can lead to life-threatening conditions.
- This medication can potentiate the effect of anticoagulants, resulting in bleeding manifestations.
- Concomitant use with beta-blockers can increase the blood concentrations of imipramine and increase side effects.
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Manufacturer Details
Brand:NILDEP
Vendor Details
Fulfillment Information: Nildep 25 MG Tablet (10) will be delivered by a licensed retail pharmacy nearest to your location. Order acceptance and fulfillment are dependent upon the verification of your doctor's valid prescription (where applicable) and the current stock of this medicine.
References:
- Imipramine Hydrochloride Tablets USP 10 mg, 25 mg, and 50 mg [Internet]. accessdata.fda.gov [cited 8 March 2022]
- Fayez R, Gupta V. Imipramine. [Updated 2021 Nov 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. 2022 [cited 8 March 2022] -
- Imipramine Tablets BP 25 mg: Summary of Product Characteristics (SmPC) - (emc) [Internet]. medicines.org.uk. 2022 [cited 8 March 2022] -
- Imipramine: Uses, Interactions, Mechanism of Action [Internet] go.drugbank.com. 2022 [cited 8 March 2022] -
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