Magprol Cr 500mg Strip Of 10 Tablets
By INTAS PHARMACEUTICALS LTD
10 Tablet(s) in Strip
₹112.61
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₹146.25
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Description
Magprol Cr Tablet is a prescription anti-epileptic medication used to manage epilepsy (seizures), bipolar disorder, and prevent migraine headaches. The active ingredient in Magprol Cr Tablet is magne
sium valproate. It is essential to take this medication as directed by your doctor, following the prescribed dosage and duration. You can take it with or without food. Magprol Cr Tablet should be swallowed whole with water, not crushed or chewed, and can be taken with or without food. Magprol Cr Tablet is generally unsafe during pregnancy due to the risk of congenital disabilities and learning difficulties. It is also likely unsafe during breastfeeding, as it may pass into breast milk. Avoid use in patients with active liver disease. Caution is required in those with kidney impairment. Before using this medicine, please inform your doctor of your complete medical history, including any other medications you are currently taking.
Product Summary
| Offer Price | ₹112.61 |
| You Save | ₹33.64 (23% on MRP) |
| Contains | Magnesium Valproate(500.0 Mg) |
| Uses | Epilepsy, manic episodes |
| Side effects | Headache, tremors of hands and feet, abnormal eye movement |
| Therapy | ANTI-EPILEPTIC |
Uses
- Magprol Cr Tablet is used in the management of epilepsy to treat generalized as well as partial seizures. It helps control abnormal electrical activity in the brain and may be used alone or along with other antiepileptic medicines....
- It is also indicated for the prophylaxis of migraine headaches in adults, where it helps reduce the frequency and severity of migraine attacks.
- Magprol Cr Tablet is used in the treatment of manic episodes associated with bipolar disorder, helping to stabilize mood and manage symptoms such as agitation, irritability, and elevated mood.
Contraindications
- Hypersensitivity: Known allergy or hypersensitivity to magnesium valproate, valproic acid, or any excipients present in the formulation.
- Hepatic Impairment: Active acute or chronic hepatitis, or a personal or family history of severe hepatitis (especially drug-induced).
- Metabolic Disorders: Patients with known urea cycle disorders (UCDs) due to the risk of life-threatening hyperammonemia.
- Mitochondrial Disorders: Patients with known mitochondrial disorders caused by mutations in the nuclear gene encoding mitochondrial polymerase gamma (POLG), such as Alpers-Huttenlocher Syndrome, and in children under two years of age who are suspected of having a POLG-related disorder....
- Pancreatic Conditions: History of severe pancreatic damage or pancreatitis.
- Porphyria: Patients with hepatic porphyria.
- Pregnancy and Childbearing Potential: Contraindicated in pregnancy for the prophylaxis of migraine and treatment of bipolar disorder. It must not be used in women of childbearing potential unless the conditions of the Pregnancy Prevention Programme are strictly met....
- Age Restriction: Not recommended for use in children under 2 years of age due to a significantly increased risk of fatal hepatotoxicity.
Side effects
- Headache
- Tremors of hands and feet
- Involuntary eye movement
- Dizziness
- Memory impairment
- Nausea
Precautions and Warnings
Pregnancy
Q:
Can I take Magprol Cr Tablet during pregnancy?
A:
No. Magprol Cr Tablet is highly teratogenic. It is strictly contraindicated during pregnancy for bipolar disorder and migraine prophylaxis. For epilepsy, it is only considered if all other treatments are ineffective. In utero exposure carries a significant risk of severe congenital malformations and long-term neurodevelopmental disorders.
Breast Feeding
Q:
Can I take Magprol Cr Tablet while breastfeeding?
A:
Magnesium valproate is excreted into human breast milk. While concentrations are generally low, adverse effects on the nursing infant cannot be completely ruled out. You must consult your prescribing doctor to weigh the benefits of breastfeeding against the clinical need for the medication.
Driving
Q:
Can I drive or operate machinery after taking Magprol Cr Tablet?
A:
Magprol Cr Tablet can cause central nervous system depression, leading to drowsiness, dizziness, and delayed reaction times. This risk is amplified if you are taking multiple antiepileptic drugs or CNS depressants. Do not drive or operate heavy machinery until you are certain how this medication affects you.
Alcohol
Q:
Is it safe to consume alcohol with Magprol Cr Tablet?
A:
No. Alcohol heavily exacerbates the central nervous system side effects of valproate, such as severe drowsiness and dizziness. Concomitant use also significantly increases the risk of drug-induced hepatotoxicity (liver damage).
Other General Warnings
Talk to your doctor if
- You experience symptoms like unexplained lethargy, persistent vomiting, or yellowing of your skin or eyes (jaundice).
- You develop sudden and severe abdominal pain.
- You notice sudden mood changes, new or worsening depression, or any suicidal thoughts or behaviors.
- You experience unusual bruising or bleeding, which may point to a decrease in your blood platelet count.
Mode of Action
How Does It Work?
Magprol Cr Tablet works by increasing the levels of gamma-aminobutyric acid (GABA), a calming neurotransmitter in the brain, and by stabilizing electrical activity of nerve cells. This helps prevent abnormal brain activity associated with seizures and mood disorders....
Directions for Use
- Magprol Cr Tablet is to be taken as a whole with adequate amount of water.
- This Tablet can be taken with or after food.
Interactions
Interactions with other medicines
- Severe Interactions (Avoid Concomitant Use):
- Carbapenem Antibiotics (e.g., Meropenem, Imipenem, Ertapenem): Co-administration can cause a rapid and significant decrease (60–100%) in valproate serum levels within 24 hours, leading to a severe risk of breakthrough seizures....
- Other Antiepileptic Drugs (AEDs):
- Lamotrigine: Valproate inhibits the metabolism of lamotrigine, significantly increasing the risk of severe skin reactions, including Stevens-Johnson syndrome.
- Phenytoin, Carbamazepine, Phenobarbital: May alter valproate plasma concentrations and lower the seizure threshold. Dosage adjustments and therapeutic drug monitoring are required.
- CNS Depressants and Psychotropics:
- Enhanced central nervous system depression when used with medications such as diazepam, quetiapine, propofol, antidepressants, and MAO inhibitors.
- Anticoagulants and Antiplatelets:
- Concurrent use with warfarin, aspirin, or other blood thinners may displace valproate from protein-binding sites and inhibit platelet aggregation, increasing the risk of bleeding.
- Other Notable Interactions:
- Zidovudine: Valproate may increase zidovudine plasma concentrations, leading to increased toxicity.
- Cholestyramine: May decrease the absorption of valproate; these medications should be administered at least 3 hours apart.
- Rifampicin and Cimetidine: Can alter the metabolism and plasma levels of valproate, necessitating clinical monitoring.
Storage and disposal
- Store in a cool and dry place away from light and moisture.
- Keep it out of the reach of children and pets.
- Discard any unused medicine properly.
Dosage
Overdose
An overdose of Magprol Cr Tablet should be immediately reported to your treating doctor or nearby hospital. Always carry the package of the Tablet along with you for easy assessment of the severity of an overdose....
Missed a Dose
You should never miss a dose of this medicine as it can aggravate your medical condition. Take the missed dose as soon as possible. Never double dose to compensate for the missed dose.
Content Details
WRITTEN BY
Ravindra Ghongade
B. Pharm
REVIEWED BY
Dr. Nikita Toshi
BDS (Bachelor of Dental Surgery), WHO FIDES member
Frequently Asked Questions (FAQs)
Q: What is the difference between magnesium valproate and sodium valproate?
A: Both contain the same active therapeutic moiety: valproic acid. The difference lies in the salt used to stabilize the compound (magnesium vs. sodium). Once absorbed, both dissociate into valproate to exert their antiepileptic and mood-stabilizing effects. Efficacy and side-effect profiles are virtually identical.
Q: Does Magprol Cr Tablet cause weight gain?
A: Yes, weight gain is a very common side effect of valproate therapy. It is often dose-dependent and may be linked to increased appetite or metabolic changes. Patients are advised to monitor their weight, maintain a balanced diet, and engage in regular physical activity.
Q: What should I do if I miss a dose of Magprol Cr Tablet?
A: Take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Never take a double dose to make up for a missed one, as this can increase the risk of toxicity.
Q: Do I need regular blood tests while taking Magprol Cr Tablet?
A: Yes. Due to the potential for liver damage, pancreatitis, and blood coagulation disorders, your doctor will likely order baseline and periodic blood tests. These monitor your liver function (LFTs), complete blood count (CBC), and valproate serum levels to ensure the medication remains within a safe and effective range.
References
View All
- CDSCO [Internet]. Cdscoonline.gov.in. 2026 [cited 10 March 2026].
- Valprol CR 500 [Internet]. Sanofi.in. 2026 [cited 10 March 2026].
- Sodium valproate: medicine to treat epilepsy and bipolar disorder [Internet]. NHS.uk; 2026 [cited 10 March 2026].
- Valproic Acid: MedlinePlus Drug Information [Internet]. U.S. National Library of Medicine; 2026 [cited 10 March 2026].
- Rahman M, Awosika AO, Nguyen H. Valproic Acid. [Updated 2024 Mar 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-.
- Valproic acid: medicine used for bipolar disorder, epilepsy and migraine - NHSNHS. Valproic acid [Internet]. National Health Service; 2026 [cited 10 March 2026].
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Product Details
Brand
MAGPROL CR
Address
Intas Pharmaceuticals Ltd - Selaqui, Dehradun-248 197.India
Country of Origin
India
Expiry Date
30/12/2027
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Disclaimer
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.
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