Macorate 200mg Tablet

• Macorate Tablet is used in the management of epilepsy to treat generalized as well as partial seizures. It helps control abnormal electrical activity in the brain and may be used alone or along with other antiepileptic medicines.
• It is also indicated for the prophylaxis of migraine headaches in adults, where it helps reduce the frequency and severity of migraine attacks.
• Macorate Tablet is used in the treatment of manic episodes associated with bipolar disorder, helping to stabilize mood and manage symptoms such as agitation, irritability, and elevated mood.

• Hypersensitivity: Known allergy or hypersensitivity to magnesium valproate, valproic acid, or any excipients present in the formulation.
• Hepatic Impairment: Active acute or chronic hepatitis, or a personal or family history of severe hepatitis (especially drug-induced).
• Metabolic Disorders: Patients with known urea cycle disorders (UCDs) due to the risk of life-threatening hyperammonemia.
• Mitochondrial Disorders: Patients with known mitochondrial disorders caused by mutations in the nuclear gene encoding mitochondrial polymerase gamma (POLG), such as Alpers-Huttenlocher Syndrome, and in children under two years of age who are suspected of having a POLG-related disorder.
• Pancreatic Conditions: History of severe pancreatic damage or pancreatitis.
• Porphyria: Patients with hepatic porphyria.
• Pregnancy and Childbearing Potential: Contraindicated in pregnancy for the prophylaxis of migraine and treatment of bipolar disorder. It must not be used in women of childbearing potential unless the conditions of the Pregnancy Prevention Programme are strictly met.
• Age Restriction: Not recommended for use in children under 2 years of age due to a significantly increased risk of fatal hepatotoxicity.

• Headache
• Tremors of hands and feet
• Involuntary eye movement
• Dizziness
• Memory impairment
• Nausea

Other General Warnings

• You experience symptoms like unexplained lethargy, persistent vomiting, or yellowing of your skin or eyes (jaundice).
• You develop sudden and severe abdominal pain.
• You notice sudden mood changes, new or worsening depression, or any suicidal thoughts or behaviors.
• You experience unusual bruising or bleeding, which may point to a decrease in your blood platelet count.

• Macorate Tablet is to be taken as a whole with adequate amount of water.
• This Tablet can be taken with or after food.

• Store in a cool and dry place away from light and moisture.
• Keep it out of the reach of children and pets.
• Discard any unused medicine properly.

Overdose

Missed a Dose

How Does It Work?

Interactions with other medicines

• Severe Interactions (Avoid Concomitant Use):
• Carbapenem Antibiotics (e.g., Meropenem, Imipenem, Ertapenem): Co-administration can cause a rapid and significant decrease (60–100%) in valproate serum levels within 24 hours, leading to a severe risk of breakthrough seizures.
• Other Antiepileptic Drugs (AEDs):
• Lamotrigine: Valproate inhibits the metabolism of lamotrigine, significantly increasing the risk of severe skin reactions, including Stevens-Johnson syndrome.
• Phenytoin, Carbamazepine, Phenobarbital: May alter valproate plasma concentrations and lower the seizure threshold. Dosage adjustments and therapeutic drug monitoring are required.
• CNS Depressants and Psychotropics:
• Enhanced central nervous system depression when used with medications such as diazepam, quetiapine, propofol, antidepressants, and MAO inhibitors.
• Anticoagulants and Antiplatelets:
• Concurrent use with warfarin, aspirin, or other blood thinners may displace valproate from protein-binding sites and inhibit platelet aggregation, increasing the risk of bleeding.
• Other Notable Interactions:
• Zidovudine: Valproate may increase zidovudine plasma concentrations, leading to increased toxicity.
• Cholestyramine: May decrease the absorption of valproate; these medications should be administered at least 3 hours apart.
• Rifampicin and Cimetidine: Can alter the metabolism and plasma levels of valproate, necessitating clinical monitoring.