EYLEA 40MG/ML INJECTION

• Neovascular (wet) age-related macular degeneration (an age-related eye condition in which abnormal blood vessels grow under the retina and can cause vision loss).
• Macular oedema secondary to retinal vein occlusion, both branch RVO and central RVO (swelling in the central part of the retina caused by a blockage in a retinal vein, either a branch vein or the main retinal vein).
• Diabetic macular oedema (swelling in the central part of the retina caused by diabetes-related damage to the small blood vessels).
• Diabetic retinopathy (damage to the blood vessels in the retina caused by diabetes, which can affect vision).
• Myopic choroidal neovascularisation (abnormal blood vessel growth beneath the retina associated with severe short-sightedness, which can cause vision problems).

• If you are allergic to aflibercept or to any of the other ingredients of Eylea 40 Injection.
• If you have an active or suspected infection in or around the eye.
• If you have severe inflammation of the eye, shown by pain or redness.

• Deterioration of eyesight
• Bleeding at the back of the eye
• A bloodshot eye, caused by bleeding from small vessels in the outer layers of the eye
• Eye pain
• Detachment or tear of one of the layers at the back of the eye, causing flashes of light with floaters
• Degeneration of the retina, causing disturbed vision
• Bleeding inside the eye
• Clouding of the lens, known as cataract
• Damage to the cornea, the front layer of the eyeball
• Increased pressure inside the eye
• Moving spots in the vision, known as floaters
• Detachment of the gel-like substance inside the eye from the retina
• A feeling of having something in the eye

Other General Warnings

• You have glaucoma.
• You have a history of seeing flashes of light or floaters, or you notice a sudden increase in the size or number of floaters.
• You have had eye surgery in the past four weeks, or are due to have eye surgery in the next four weeks.
• You have a severe form of retinal vein occlusion, as treatment is not recommended in that case.
• You have had a stroke, a mini-stroke or a heart attack in the last six months.
• You are pregnant or planning a pregnancy. This medicine should not be used in pregnancy unless your doctor decides the benefit outweighs the risk to the baby.
• You could become pregnant, as effective contraception is needed during treatment and for at least three months after the last injection.
• You are breastfeeding, as this medicine is not recommended while breastfeeding.
• You have any known allergy, including to polysorbates.
• You start experiencing eye pain, increasing discomfort, worsening redness, blurred or reduced vision, or increased sensitivity to light after an injection.

• Eylea 40 Injection is given only by a healthcare professional experienced in giving injections into the eye.
• It is given as an injection into the jelly of the eye, known as an intravitreal injection, under clean and sterile conditions.
• Before the injection, your eye will be cleaned with a disinfectant eyewash to prevent infection, and a local anaesthetic will be given so that the injection is not painful.
• The dose, the treatment schedule and the interval between injections are decided by your doctor and depend on the condition being treated and how you respond.
• Never try to change, delay or skip an appointment on your own.
• Giving it into both eyes at the same time has not been studied and may raise the risk of side effects.
• Speak to your doctor before stopping treatment.

• Eylea 40 Injection is a hospital-administered medicine, so the clinic or pharmacy normally handles its storage, preparation and disposal.
• Store it in a refrigerator, between 2 and 8 degrees Celsius. Do not freeze it.
• An unopened vial may be kept outside the refrigerator, below 25 degrees Celsius, for a short period only, as stated on the pack.
• Store it in the original package to protect it from light.
• Keep it out of the sight and reach of children.
• Do not use it after the expiry date printed on the carton and the label. The expiry date refers to the last day of that month.
• Do not throw medicines away with household waste or down the drain. Ask your pharmacist how to dispose of medicines you no longer need.

• Contact your doctor immediately if your vision suddenly drops, or the eye becomes more painful or red after an injection.
• Arrange for someone to take you home after the injection. Your vision can be blurred for a while, so do not plan to drive yourself.
• Keep every appointment, including the follow-up examinations. The treatment schedule is set from what your doctor sees at each check.
• Expect a gritty feeling or a red patch on the white of the eye afterwards. That is common and settles on its own.
• Tell your doctor if you have glaucoma, or if you have recently had or are about to have eye surgery.
• If you could become pregnant, use reliable contraception during treatment and for at least three months after the last injection.

Overdose

Missed a Dose

Interactions with other medicines

• Tell your doctor if you are using, have recently used, or might use any other medicines, including ones bought without a prescription.
• No specific medicine interactions have been established for Eylea 40 Injection, because very little of it passes into the bloodstream after an eye injection.
• Tell your doctor if you take a blood thinner or an antiplatelet medicine, and mention any eye drops or eye treatments you already use.

Interactions with food items

• Eylea 40 Injection is injected into the eye by a healthcare professional, so interactions with food do not apply.