Home Covance D Cp 50/12.5mg Bottle Of 30 Tablets

Covance D Cp 50/12.5mg Bottle Of 30 Tablets

By RANBAXY LABORATORIES (SUN PHARMA)

30 Tablet(s) in Bottle

MRP ₹119.50*

Inclusive of all taxes

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Covance D Cp 50/12.5mg Bottle Of 30 Tablets Description

Covance D Tablet is a combination of Hydrochlorothiazide and Losartan, an anti-hypertensive. Covance D Tablet is used to treat high blood pressure when it cannot be managed using single medicine. Los

artan and Hydrochlorothiazide belong to a class of medicines known as "Angiotensin receptor blocker (ARBs)" and "Diuretics" respectively. This medicine acts by relaxing the blood vessels and increasing diuresis, which works synergistically to lower the raised blood pressure. Pregnant women should not take this medicine. Do not stop taking Covance D abruptly, as it may cause sudden hypertensive crises and worsen your health further. Always take it as prescribed and advised by your doctor. Visit a nearby clinic or hospital in case of any side effect that worsens or remain persistent.

Product Summary

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Contains	Hydrochlorothiazide(12.5 Mg) + Losartan(50.0 Mg)
Uses	High blood pressure
Side effects	Breathlessness, dizziness, chest pain, nausea
Therapy	ANTI-HYPERTENSIVE

Check more medicines with composition as Hydrochlorothiazide(12.5 Mg) + Losartan(50.0 Mg)

Precautions and Warnings

Uses of Covance D Cp 50/12.5mg Bottle Of 30 Tablets

Covance D Tablet is used to treat high blood pressure when Hydrochlorothiazide and Losartan alone is unable to control blood pressure.

Contraindications of Covance D Cp 50/12.5mg Bottle Of 30 Tablets

If you are allergic to losartan, hydrochhlorothiazide or any of the ingredients of Covance D Tablet.
If you are allergic to sulfonamide medicines such as co-trimoxazole.
If you have a low level of potassium & sodium or high levels of calcium in your blood.
If you have serious liver disorders and problems related to bile duct (canal connecting liver to intestine) like cholestasis.
If you have kidney disease due to which you are not producing enough urine.
If you have diabetes or kidney problem and taking a medicine for high blood pressure like Aliskiren.
If you have gout.
If you are pregnant for more than 3 months.

Side effects of Covance D Cp 50/12.5mg Bottle Of 30 Tablets

Cough, nasal congestion and sinusitis
Nausea, diarrhoea, stomach pain and indigestion
Chest pain and tiredness
Muscle pain, back pain and pain in the legs
Headache, weakness, dizziness and sleeplessness
Kidney and liver dysfunction
Low blood sugar levels

Precautions and Warnings of Covance D Cp 50/12.5mg Bottle Of 30 Tablets

Pregnancy

Can I take Covance D Tablet during pregnancy?

Components of Covance D Tablet are known to cause fetal abnormalities and lead to threatened pregnancy; thus, they should never be taken during pregnancy.
If you are on this medicine and planning pregnancy, then inform your doctor as your medicine needs to be changed.

Breast Feeding

Can I take Covance D Tablet while breastfeeding?

It is advised not to use Covance D Tablet when you are breastfeeding and especially to a premature baby. It can cause excessive urine production and can affect milk production.

Driving

Can I drive if I have consumed Covance D Tablet?

You may experience dizziness, drowsiness, especially during the start of the treatment or if when the dose is increased of Covance D Tablet. Hence, be cautious while driving or operating any machinery during treatment with this medicine.

Alcohol

Can I consume alcohol with Covance D Tablet?

Consuming alcohol will intensify the effects of Covance D Tablet and may cause a fall in blood pressure which may be harmful. You are best advised to avoid alcohol when you are taking this medicine.

Other General Warnings

Talk to your doctor if

You have a history of swelling of the face, lips, throat or tongue due to water retention.
You have blocked arteries of your kidneys or recently had a kidney transplant or have only one functioning kidney.
You experience fainting and giddiness, especially after the first dose.
You are planning a pregnancy, this medicine will be changed.
You are facing problems with liver function and related organs-like cholestasis and biliary obstructive.
Your kidneys are not functioning correctly or you have underlying kidney disease like renal artery stenosis (Narrow kidney blood vessels).
You have been experiencing fluid losses within your body due to diarrhoea, vomiting, etc.
You have serious heart valve-related problems like congestive heart failure, aortic or mitral stenosis and ischaemic cardiopathy.
You are suffering from primary aldosteronism (a condition of excess production of the hormone aldosterone from the adrenal glands).
You have diabetes as this medicine may affect your blood glucose levels, glucose monitoring is needed.
You have an electrolyte imbalance of sodium, magnesium, potassium and have symptoms of dryness of mouth, thirst, drowsiness, muscle pain, nausea, vomiting, etc.
You have galactose intolerance (small intestine's inability to transport and absorb glucose and galactose).
You develop eye pain and a decrease in vision.
You had any skin cancer or developed any skin lesions.
You have gout, diabetes, bronchial asthma or any autoimmune diseases like systemic lupus erythematosus.

Mode of Action of Covance D Cp 50/12.5mg Bottle Of 30 Tablets

How Does It Work?

Losartan lowers the blood pressure by blocking the action of a hormone called angiotensin responsible for narrowing of blood vessels and rise in blood pressure.
Hydrochlorothiazide acts by increasing the production of urine and loss of water and salt from body, thereby lowering the blood pressure. Both the medicines act by different mechanisms resulting in ef...
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Directions for Use of Covance D Cp 50/12.5mg Bottle Of 30 Tablets

Covance D Tablet should be consumed as a whole with a sufficient amount of water with or without food.
Do not change your dose unless your doctor tells you to do. Never stop this medicine on your own.
This medicine tends to catch moisture and should be taken out from the blister just before use.

Interactions of Covance D Cp 50/12.5mg Bottle Of 30 Tablets

Interactions with other medicines

Your blood potassium levels may go down if you are taking steroids, antifungals like Amphotericin.
Medicines used to treat depression or other mental conditions like Lithium, Thioridazine and Chlorpromazine.
Your blood potassium levels may increase if you are taking potassium supplements (Amiloride, Spironolactone) and Trimethoprim.
You may experience low blood sugar if you are taking medicine for diabetes like Insulin and Metformin along with this medicine (severe kidney problems may also arise with Metformin).
This medicine can decrease your blood pressure abruptly if taken with other blood pressure-lowering medicine.
Your blood cell production may be hampered if you take this with medicines like Cyclophosphamide and Methotrexate.
Medicines used to treat pain and inflammation like Aspirin, Ibuprofen and Naproxen interferes with the way this medicine works
You may experience anaemia if you are taking medicine like Methyldopa.
Concomitant use of Cyclosporin may increase the risk of gout.
You may experience abnormal heart rhythms if you are taking medicine for heart failure like Digoxin.
Medicines that may not be able to work properly due to increased potassium levels are used to treat irregular heartbeats like Quinidine, Sotalol and Amiodarone.
This medicine can increase blood calcium levels if you are taking vitamin D and calcium supplements.
Other medicines like Probenecid, Allopurinol, Atropine, Biperiden and muscle relaxants like Tubocurarine, Cholestyramine and Colestipol.

Interactions with food items

Make sure to have a low salt diet because excess salt in your diet may decrease the effects of this medicine.

Storage and disposal of Covance D Cp 50/12.5mg Bottle Of 30 Tablets

Store this medicine below 30°C.
Keep this medicine in the original container to protect it from light and moisture.

Dosage of Covance D Cp 50/12.5mg Bottle Of 30 Tablets

Overdose

Symptoms of overdose may include low blood pressure, irregular heart rhythms, dizziness, excessive urination, nausea and vomiting. If you think you have taken too much of this medicine, contact your d...

It would be best if you never miss a dose of your blood pressure medicine as it may lead to serious high blood pressure-related problems.
If you missed any dose, take it as soon as you remember.
If it is time for the next dose, skip the missed dose and continue with your regular dosing schedule.
Do not take a double dose of this medicine to compensate for the missed one.

Content Details

WRITTEN BY

Dr. Mansi Savla

B. Pharm, PharmD

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: Will Covance D Tablet start lowering my blood pressure immediately after I take this medicine?

A: Blood pressure will not start to lower after you start taking Covance D Tablet. It will take 3-4 weeks for your blood pressure to be normalized. This medicine is not recommended to be used in patients who have not received prior therapy for high blood pressure and should preferably be used in patients who had exposure to both the medicines as single tablets previously.

Q: Can I use Covance D Tablet in kidney and liver disease?

A: Covance D Tablet can be used at a normal dose in patients with mild to moderate kidney failure (i.e., creatinine clearance is above 30-50 ml/min). However, it should not be used in severe kidney failure or in patients on hemodialysis. Similarly, this medicine can be used but with caution in patients with mild-moderate liver disease. It should not be used in patients with severe liver impairment.

Q: Is there anything else I need to know before using Covance D Tablet?

Your blood pressure, kidney function and blood potassium levels need to be regularly monitored while you are taking this medicine.
Caution is advised (inform your doctor) if you are undergoing any radiography with iodine contrast media.
Covance D Tablet should not be used in children and adolescents under 18 years of age.

References

Product Details

Brand

COVANCE

Expires on or After

13/02/2025

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Last Updated on: 28 Apr 2021 | 01:29 PM (IST)

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Disclaimer

The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.

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