Brufungin 70Mg Dry Vial Of 1 Powder For Injection

• Brufungin Powder For Injection is used to treat invasive candidiasis, including candidemia (Candida infection in the blood), intra-abdominal abscesses, peritonitis (infection of the abdominal lining), and pleural space infections (infection around the lungs).
• It is also used as empirical treatment for suspected fungal infections in patients with fever and neutropenia (low levels of infection-fighting white blood cells).

• Known hypersensitivity (allergy, for example anaphylaxis) to caspofungin or any component of Brufungin Powder For Injection.

• Fever (pyrexia)
• Diarrhea
• Raised liver enzymes (ALT/AST) and raised alkaline phosphatase
• Low potassium levels in the blood
• Chills
• Headache
• Nausea, vomiting, abdominal pain
• Skin rash, redness (erythema)
• Low blood pressure
• Swelling of the arms or legs (peripheral edema)
• Cough
• Pneumonia
• Raised bilirubin
• Inflammation of the vein at the infusion site (phlebitis)

Other General Warnings

• You have liver disease. Your doctor may check your liver function regularly. Inform your doctor if you develop abdominal pain, loss of appetite, darkened urine, or yellowing of the eyes or skin (jaundice).
• You are taking cyclosporine, tacrolimus, or a medicine that lowers Brufungin Powder For Injection levels (rifampin, efavirenz, nevirapine, carbamazepine, dexamethasone, phenytoin).
• Attend all the scheduled blood tests as recommended by your doctor.

• Brufungin Powder For Injection is given by a doctor or nurse as a slow intravenous infusion.
• It should not be given as an intravenous bolus (a rapid injection). Do not mix or infuse it with other medicines, and do not use diluents containing dextrose.
• Patients should never attempt to change, delay, skip, or repeat a dose on their own.

• Brufungin Powder For Injection is a hospital-administered medicine, so the pharmacy normally handles storage, preparation, and disposal.
• Store unopened vials at 20°C to 25°C (68°F to 77°F).

• Report any rash, facial swelling, itching, wheezing, or a sensation of warmth during the infusion immediately.
• Tell your treatment team right away if you notice signs of an allergic reaction.
• Your liver tests may be checked and monitored during treatment, especially if you are taking cyclosporine.
• Report yellowing of the skin or eyes, or severe abdominal pain.
• Tell your doctor if you are taking cyclosporine, tacrolimus, rifampin, efavirenz, nevirapine, carbamazepine, dexamethasone, or phenytoin.
• Report any pain, redness, or swelling at the infusion site.

Overdose

Missed a Dose

Interactions with other medicines

• Cyclosporine increases the blood level of Brufungin Powder For Injection and has been linked to temporary rises in liver enzymes (ALT and AST). The two are used together only if the potential benefit outweighs the potential risk, and liver tests are monitored.
• Brufungin Powder For Injection reduces the blood level of tacrolimus. Tacrolimus blood levels should be monitored and the tacrolimus dose adjusted as needed.
• Rifampin (a strong inducer of liver enzymes) reduces the level of Brufungin Powder For Injection.
• Other enzyme inducers such as efavirenz, nevirapine, phenytoin, dexamethasone, or carbamazepine may lower Brufungin Powder For Injection levels.
• Brufungin Powder For Injection must not be mixed or infused with other medicines. Diluents containing dextrose (glucose) must not be used.
• Patients should tell their doctor about all prescription medicines, over-the-counter medicines, supplements, and herbal products they are taking before and during Brufungin Powder For Injection treatment.