Amitone (Maneesh) Syrup 200 Ml
200ml Syrup in BottleWe do not sell this product
Made by
INTAS PHARMACEUTICALS LTD
Dosage
SYRUP
Expiry
Product Summary
| Salt Content | Amitriptyline |
| Uses | Management of depression, neuropathic pain, and migraine |
| Therapy | Anti-depressant |
| Side effects | Constipation, urinary retention, Weight gain, Confusion, Orthostatic hypotension (sudden lowering of blood pressure on standing), Tiredness, Blurred vision, Dryness in mouth |
Assurance
available
Regulated
Medical Description
Amitone Syrup is a prescription medication. It contains Amitriptyline, which belongs to a group of medications called tricyclic antidepressants. Apart from its use in the management of major depressive disorders, it is also commonly used in the management of neuropathic pain and migraine in varying doses. Each bottle of Amitone Syrup contains 200mL of product.
Depression is a condition characterised by a pervasive low mood. Patients present with complaints like feeling low, decreased motivation, feelings of hopelessness and dread, and loss of interest in daily activities, which can be debilitating. Multiple brain pathways and chemical messengers are indicated in depression, chiefly serotonin, norepinephrine and dopamine. Antidepressant medications target these pathways and neurotransmitters to help relieve the symptoms of depression.
The medication should be taken as recommended by the doctor. It should not be abruptly started or stopped, as it may cause a relapse of symptoms, withdrawal symptoms and worsening of an underlying condition. Taking medicine at the same time every day is advisable for maximum efficacy.
Uses
- Management of Major Depressive Disorder
- Management of Neuropathic pain
- Management of Migraines
Contraindications
- Hypersensitivity reactions – avoid using this medication in case of hypersensitivity reactions to these medications/ inactive ingredients.
- This medication should not be used in patients with a recent history of heart conditions such as irregular heart rhythm or myocardial infarction (heart attack).
- It is contraindicated in patients with angle-closure glaucoma (increased pressure in the eye)
- It is recommended to discontinue this medication before elective surgery to decrease the risk of interaction with anaesthetic agents.
- This medication decreases the seizure threshold and should be used cautiously in patients with epilepsy/ seizure disorders.
- Contraindicated in children < 12 years of age.
- It should be used cautiously in adolescents and young adults <24 years of age as it may increase suicidal ideation.
Side effects
- Weight Gain
- Constipation
- Dry mouth
- Dizziness
- Headache
- Somnolence (Sleepiness)
- Urinary retention
- Orthostatic hypotension (sudden lowering of blood pressure on standing up)
- Dizziness
- Blurred vision
- Increased heart rate (tachycardia)
- Confusion
- Increased risk of bone fractures
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You should inform your doctor about any other medications you are taking. This medicine interacts with many other medications that use the same metabolic enzymes.
- If you notice any discomfort or sudden mood changes.
Directions for Use
- This medication should be taken as prescribed by the treating physician.
- It is recommended to take this medication on a regular schedule, i.e., at the same time every day, for optimal pharmacological effects of this medication.
- Shake the bottle well before use.
- Use a measuring cup and accurately measure the quantity of syrup as prescribed by your treating physician.
- It is recommended to finish the entire course of this medication as prescribed by your treating doctor.
- Abrupt stoppage of the drug can cause withdrawal side effects. Consult your doctor before stopping this medication.
- This medication may require 2-4 weeks for onset of action. Do not increase the dose without explicit advice from your treating physician.
- This medication can be taken with or without food.
- Driving/ use of heavy machinery is not advised while using this medication.
- Inform your doctor regarding other medications you may be taking to review and prevent any drug interaction associated effects.
Storage and disposal
Store in a cool and dry place away from direct light and moisture. Do not use the medicine after the date of expiration. Keep the medicines away from children and pets. Do not flush the medication down the toilet. Dispose of it with biomedical waste only.
Dosage
Overdose
Amitriptyline toxicity can be severe and even fatal. In the event of an overdose, the patient may present with sedation, seizure, coma, increased heart rate, low blood pressure, dilated pupils, dry mouth, difficulty in passing urine or stools, abnormal heart rhythms, low urine output. In case of a suspected overdose, immediately rush the patient to the nearest tertiary care hospital for emergency management as it is life-threatening.
Missed a Dose
If you miss a dose of this medicine, it is advised to take it as soon as possible. If the duration missed is too long, and it is almost time for the next dose, it is recommended to skip the missed dose and go back to the regular schedule. Do not double the dose.
Mode of Action
How Does It Work?
Amitriptyline belongs to a class of medications called Tricyclic antidepressants (TCAs) that acts on multiple brain pathways to increase levels of certain chemical messengers called neurotransmitters. It works by increasing the neurotransmitters serotonin, and nor-epinephrine levels, which affect the mood and personality. It also causes sleepiness.
In the long term, it increases the levels of BDNF (brain-derived neurotrophic factor). This reduces the symptoms of Major Depressive Disorder. The action of this drug on serotonin and nor-epinephrine is also indicated in the management of neuropathic pain and migraine.
It is important to note that Amitone Syrup as an antidepressant requires about 2-4 weeks of continued use for optimal onset of action to begin.
Interactions
Interactions with other medicines
- This medication affects the heart rhythm. It should not be used in addition to other medications with the same effect, as it may result in potentially life-threatening conditions. Examples include astemizole, cisapride, etc.
- This medication should not be used concomitantly with MAOIs (Monoamine oxidase inhibitors) or within 14 days of MAOIs and vice versa. Examples of MAOIs include Selegiline, Rasagiline.
- This medication should not be used with other drugs known to increase serotonin levels, like isocarboxazid, as it may result in a potentially fatal condition.
- This medication should not be used with alcohol or other CNS depressants.
- This medication should not be mixed with opioid medications or benzodiazepines.
Frequently Asked Questions (FAQs)
Articles
View All
Chronic Condition Articles
View All
Did you find this helpful?
Explore More at Pharmeasy
Manufacturer Details
Brand:AMITONE
Manufacturer Name:INTAS PHARMACEUTICALS LTD
Address:<p>1. Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.</p>
Country of Origin:India
Vendor Details
Fulfillment Information: Amitone Syrup (200) will be delivered by a licensed retail pharmacy nearest to your location. Order acceptance and fulfillment are dependent upon the verification of your doctor's valid prescription (where applicable) and the current stock of this medicine.
References:
- Thour A, Marwaha R. Amitriptyline. [Updated 2022 Feb 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from
- Amitriptyline 10mg BP - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2022 [cited 10 March 2022]. Available from:
- SANDOZ (amitriptyline hydrochloride).
In Case of Any Issues Contact Us
Email Id:care@pharmeasy.in
Phone Number:7666100300
Address:D-37/1, Opp. Sandoz, TTC Industrial Area, MIDC Industrial Area, Turbhe, Navi Mumbai, Maharashtra 400703
Disclaimer
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.
