Aculip Tablet
By SHINE PHARMACEUTICALS LTD
20 Tablet(s) in Strip
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Aculip Tablet Description
Aculip is a prescription medication used in the treatment of depression and associated anxiety. It is a combination of Amitriptyline and Chlordiazepoxide. This combination is utilised to treat modera
te to severe depression and anxiety. Depression is a medical condition associated with low mood, hopelessness, inability to complete daily activities, difficulty sleeping, or overall sadness. This may be accompanied by anxiety which is a condition of excessive worry and feelings of fear and nervousness. Increased sweating or trembling may be seen. Both of these conditions affect daily activities. Aculip should be taken in the dose and duration prescribed by a medical professional. Aculip should not be stopped abruptly. In case of any side effects, it is advisable to consult the prescribing doctor. For best results, the tablet should be taken at the same time each day.
Product Summary
| Offer Price | ₹84.30 |
| You Save | ₹11.50 (12% on MRP) |
| Contains | Amitriptyline(25.0 Mg) + Chlordiazepoxide(10.0 Mg) |
| Uses | Treatment of Major Depressive Disorder with moderate to severe anxiety |
| Side effects | Constipation, urinary retention, weight gain, confusion, orthostatic hypotension (sudden lowering of blood pressure on standing), tiredness |
| Therapy | ANTI-DEPRESSANT |
Check more medicines with composition as Amitriptyline(25.0 Mg) + Chlordiazepoxide(10.0 Mg)
Uses of Aculip Tablet
- Treatment of Major depressive disorder (MDD)
- Treatment of Moderate to severe anxiety
Contraindications of Aculip Tablet
- It is contraindicated in case of hypersensitivity to either of the components.
- If you have a recent history of heart attack, heart failure, or irregular heart rhythm.
- If you have angle-closure glaucoma.
- If you have epilepsy/seizure disorders patients.
- If you have any pulmonary diseases.
- If you are planning a pregnancy, or are pregnant or breastfeeding.
Side effects of Aculip Tablet
- Constipation
- Urinary retention
- Dry mouth
- Orthostatic hypotension (unanticipated lowering of blood pressure on standing up)
- Dizziness
- Headache
Precautions and Warnings of Aculip Tablet
Pregnancy
Q:
Can I take Aculip during pregnancy?
A:
No, Aculip is unsafe in pregnancy and should not be taken while pregnant or if the person intends to conceive. Consult your doctor, and inform them regarding your health status.
Breast Feeding
Q:
Can I take Aculip while breastfeeding?
A:
Aculip is generally not advised while breastfeeding. Discuss with your doctor for more information.
Driving
Q:
Can I drive if I have taken Aculip?
A:
Driving and operating other heavy machinery while on Aculip is not recommended as it may cause sedation and drowsiness.
Alcohol
Q:
Can I consume alcohol with the Aculip?
A:
Alcohol consumption while on Aculip is contraindicated as it may cause increased sedation and other adverse effects.
Other General Warnings
Talk to your doctor if
- You must inform your doctor in case you are on any other medications. There are several medicines that may affect the metabolism of this tablet and modify the blood levels. Appropriate dose adjustment is needed....
Mode of Action of Aculip Tablet
How Does It Work?
The first active ingredient in Aculip is amitriptyline, a Tricyclic antidepressant (TCA). Aculip acts in the central nervous system and regulates the levels of several chemical mediators known as neurotransmitters. One of the most important of these neurotransmitters is serotonin. By increasing serotonin levels, Aculip helps improve the mood and combat symptoms of depression and anxiety.
The second active ingredient in Aculip is chlordiazepoxide which is a benzodiazepine. This acts on another neurotransmitter called GABA (gamma-aminobutyric acid). By increasing the levels of GABA, it helps increase feelings of calm. It also acts on a particular part of the brain called the amygdala, which functions as the fear centre. By reducing activity in this area, it provides relief from the symptoms of anxiety....
Directions for Use of Aculip Tablet
- Aculip should be taken as prescribed by the treating physician.
- Consult your doctor before stopping Aculip.
- Unexpected stoppage of the medication can compel withdrawal side effects.
- Swallow Aculip as a whole. Do not granulate, break, or bite this tablet.
- It is recommended to consume Aculip on a regular schedule, i.e., at the same time every day, for optimal pharmacological effects of Aculip.
- Inform your doctor regarding other medications you may be taking to review and prevent any medication interaction associated effects.
Interactions of Aculip Tablet
Interactions with other medicines
- Aculip can cause arrhythmias and should not be used with any medications that affect heart rhythm, such as astemizole, cisapride, etc.
- Aculip should not be used with any medications that are known to raise the levels of serotonin as it can result in a fatal condition called serotonin syndrome. These include antidepressants, opioids such as tramadol and fentanyl, lithium, olanzapine, etc....
- Aculip should not be given along with monoamine oxidase inhibitors. If they must be given, a minimum gap of two weeks is required.
- Aculip should not be taken with central nervous system depressants. These include alcohol and other benzodiazepines such as clonazepam and alprazolam.
- Aculip needs to be used with caution along with anaesthetic agents, and it is generally advisable to discontinue the tablet before any major surgery.
Interactions with food items
- Aculip does not have any specific interactions with food.
Storage and disposal of Aculip Tablet
Store under 30’C. Keep out of reach of children and pets. Do not expose to direct sunlight or moisture. Discard the medication after the date of expiration.
Dosage of Aculip Tablet
Overdose
Both the active ingredients of Aculip can cause toxicity if taken in higher doses than prescribed. Amitriptyline can cause sedation, raised and irregular heart rate, dizziness, dry mouth, urine retention, and even coma. Chlordiazepoxide toxicity can aggravate drowsiness. In case of any suspected overdose, visit the nearest emergency care centre....
Missed a Dose
If you miss a dose of this pill, it is advised to be taken at the earliest. If the duration missed is too long, and it is almost time for the next dose, it is recommended to skip the missed dose and go back to the regular schedule. Do not double the dose of the tablet....
Content Details
WRITTEN BY
REVIEWED BY
Dr. Bhavika Shah
MBBS, MD (Dermatology), DNB (Dermatology)
Frequently Asked Questions (FAQs)
Q: After taking Aculip, I feel very dizzy and tired. I feel it is not suiting me. Can I stop taking it?
A: No. Dizziness and drowsiness are known side effects of Aculip; it is not recommended to stop the medication without consulting your doctor. Always discuss any side effects you may be facing with your doctor to adjust the dose as required.
Q: I have a chronic problem of backache. Is it okay to take other painkillers while taking this tablet?
A: There are different types of painkillers prescribed for different indications. Certain painkillers may contain opioids and must be avoided with Aculip. Consult a doctor with details of all the medications that you are taking.
Q: Can Aculip cause constipation?
A: Aculip may cause constipation as a side-effect. However, constipation can be treated by drinking plenty of fluids and eating fibrous foods. If the constipation is severe, you should see a doctor.
References
View All
- Thour A, Marwaha R. Amitriptyline. [Updated 2021 Jul 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from:
- Ahwazi HH, Abdijadid S. Chlordiazepoxide. [Updated 2020 Nov 22]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from:
- Levate (Amitriptyline).
Product Details
Brand
ACULIP
Expires on or After
06/05/2025
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Disclaimer
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.
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