Actamase Forte 2.25gm Dry Vial Of 1 Powder For Injection

• If you are allergic to cefepime, tazobactam or any other ingredients of Actamase Forte powder for injection.
• If you have a history of allergy to any other antibiotics.

• Diarrhoea
• Constipation
• Nausea
• Vomiting
• Indigestion
• Stomach pain
• Fever
• Anaemia
• Fungal infection (candidiasis)
• Headache
• Sleeplessness
• Rashes
• Itching
• Inflammation and swelling at the injection site

Other General Warnings

• You have a history of hypersensitivity reactions to penicillins, other beta-lactam agents (like cephalosporin, monobactam, or carbapenem), or other allergens.
• You experience any signs of excessive systemic inflammation, such as fever, enlarged liver or spleen, high fat levels in the blood, low blood clotting factor, high iron levels, low blood cell counts, or evidence of hemophagocytosis.
• You develop a skin rash, especially if the lesions progress or worsen.
• You experience severe, persistent diarrhoea during or after antibacterial treatment.
• You notice any bleeding manifestations.
• You are receiving prolonged therapy with this medication, as regular blood tests may be needed.
• You experience convulsions or seizures, especially if you have impaired renal function.
• You have low potassium reserves or are taking other medications that might lower your potassium levels.
• You have kidney disease or are undergoing hemodialysis.
• You are on a controlled sodium diet, as this medication contains sodium.
• You are also taking vancomycin, as this combination may increase the risk of acute kidney injury.

• Actamase Forte powder for injection will be given to you in the hospital by your doctor or nurse. Do not self-inject this medicine.
• Follow any instructions suggested by the doctor or nurse during the procedure or for aftercare.

• Store this medicine at a temperature of 25 °C or below.
• Protect it from light and heat.
• Keep it out of the reach of children and pets.
• Any unused portion should not be stored and discarded properly.

Overdose

Missed a Dose

How Does It Work?

• Cefepime works by inhibiting bacterial cell wall synthesis; the absence of a bacterial cell wall results in the death of bacteria.
• Tazobactam is a medication that enhances the effectiveness of certain antibiotics. It does this by blocking an enzyme (called beta-lactamase) made by some bacteria that can destroy antibiotics. By stopping this enzyme, tazobactam protects the antibiotic and helps it kill the bacteria more effectively.

Interactions with other medicines

• Medicines used to relax the muscles during surgery, like Vecuronium.
• Potent diuretics such as furosemide.
• High doses of aminoglycosides during the treatment with Actamase Forte powder for injection should be monitored carefully as it increases the risk of nephrotoxicity.
• Close monitoring of blood function is required if you are on medicines used to stop blood-thinning, like Warfarin.
• Medicines used to treat certain types of cancer, such as methotrexate.
• Medicines used to treat gout include probenecid.
• If you have kidney problems and you are taking antibiotics like Tobramycin, Gentamicin and Vancomycin.
• Some medicines can affect the way Actamase Forte powder for injection works, or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
• Tell your doctor about all the medicines, supplements or herbal supplements you are currently taking or might take to avoid any possible interaction.