Zolpidem+Melatonin

Description

Zolpidem + Melatonin is a combination medicine used for managing insomnia, espe

cially in individuals who have difficulty falling asleep or maintaining a normal sleep cycle. Zolpidem is a sedative-hypnotic that enhances the action of GABA, a calming neurotransmitter in the brain, helping to slow brain activity and promote deep, restful sleep. Melatonin is a natural hormone released by the brain in response to darkness and helps regulate the body’s internal clock, supporting a healthy circadian rhythm. By combining these two mechanisms, the medicine helps improve sleep onset, quality, and overall sleep–wake balance. Because it can cause drowsiness, dizziness, confusion, unusual dreams, memory impairment, or next-day sleepiness, it must be taken strictly under medical guidance and monitored carefully. Abruptly stopping the medication without a doctor’s advice can worsen insomnia or trigger withdrawal symptoms, so dosage changes should always be supervised.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses

As per CDSCO-
Treatment of Insomnia

Contraindications

When should one not use Zolpidem+Melatonin

If you are allergic to Zolpidem or Melatonin
If you are experiencing sudden mood changes or suicidal ideation
If you have myasthenia gravis (a disease that causes muscle weakness)
If you have liver impairment
If you have kidney problems
If you have any history of drug or alcohol addiction
If you have any mental health problems
If you have respiratory problems like sleep apnea

Side effects

Common side effects of this drug are:

Nausea
Diarrhoea
Dry mouth
Headache
Dizziness
Drowsiness

Precautions and Warnings

Pregnancy

Can I take Zolpidem + Melatonin during pregnancy?

No, Zolpidem + Melatonins are unsafe during pregnancy. Some research studies have shown a definite risk to the developing unborn baby. Sometimes your doctor may prescribe this medicine during severe conditions if they think the benefits outweigh the risks. Do not take it without consulting your doctor.

Breast Feeding

Can I take Zolpidem + Melatonin while breastfeeding?

Zolpidem + Melatonins can be unsafe during breastfeeding as it may get excreted into breast milk and can affect the baby. Consult your doctor and discuss the potential risks and benefits of this medicine. Your doctor may advise you to discontinue breastfeeding or prescribe low doses if you continue breastfeeding.

Driving

Can I drive if I have taken Zolpidem + Melatonin?

Zolpidem + Melatonin may cause side effects that could affect your ability to drive. The medicine may decrease alertness, affect your vision and can cause dizziness, lightheadedness. Avoid driving if you are experiencing the side effects mentioned above after taking this medicine.

Alcohol

Can I consume alcohol with the Zolpidem + Melatonin?

No, do not consume alcohol with Zolpidem + Melatonin, as it increases the severity of side effects like dizziness, drowsiness, lethargy, blurred vision, liver injury, etc. It also worsens the symptoms for which you are taking this medicine.

Other General Warnings

Talk to your doctor if

You have any allergic reactions after taking Zolpidem + Melatonin.
You have any suicidal ideation or self-harming thoughts
You experience any severe side effects
Your symptoms do not improve or there is worsening of your condition
You have a history of epilepsy or fits and are taking antiepileptic medication
You have withdrawal symptoms like agitation, nausea, tremor, sweating and confusion

Mode of Action

How Does It Work?

It is a sedative-hypnotic combination of medicine. Zolpidem works by increasing the activity chemical messenger in the brain called Gamma-aminobutyric acid (GABA), which act as a natural nerve-calming...

Interactions

Interactions with other medicines

Tell your doctor and pharmacist what prescription and non-prescription medications, herbal products, vitamins and nutritional supplements, you are consuming or plan to take as there is a chance of dru...
Read more
Interaction with antidepressants or mood-elevating medicines like fluoxetine and desipramine can cause increased side effects.
Interaction with antihistamines (allergy medicines), opioid painkillers, sleeping pills, etc, can increase drowsiness and fatigue.
Interaction with antifungal medications like itraconazole and ketoconazole can reduce its effects of it.

Interactions with food items

You should avoid caffeine-containing drinks like cola, tea, coffee etc, especially in the evening

Dosage

Overdose

Zolpidem + Melatonin overdose can cause symptoms like drowsiness, problems with coordination, confusion, difficulty speaking, slowed breathing or heartbeat and loss of consciousness. If you overdose o...

Missed a Dose

Missed doses of Zolpidem + Melatonin should be taken right away unless it is almost time for the next dose. In that case, you should skip the forgotten dose (rather than taking a double dose) and take...

Content Details

WRITTEN BY

Ravindra Ghongade

B. Pharm

REVIEWED BY

Dr. Nikita Toshi

BDS (Bachelor of Dental Surgery), WHO FIDES member

Frequently Asked Questions (FAQs)

Q: Can I get addicted to Zolpidem + Melatonin?

A: If you take Zolpidem + Melatonint for a few weeks, you're unlikely to become addicted to this medicine. However, if you are taking it for longer than 4 weeks then you may get dependent on it. It's better to consult your doctor if you have any queries regarding this issue.

Q: Can I Stop taking the Zolpidem + Melatonin on my own after the desired effect?

A: No, Do not stop taking Zolpidem + Melatonin despite having improvement in your condition . Continue the medicine as prescribed by your doctor; otherwise, it may lead to withdrawal symptoms. Talk to your doctor before stopping the medicine as doses need to be slowly tapered to avoid undesirable side effects.

Q: Does taking Zolpidem + Melatonin more than the recommended dose will resolve my symptoms quickly?

A: No, do not take Zolpidem + Melatonin more than the recommended dose as it may lead to overdose or may worsen your condition. Consult your doctor if you have any queries about the doses and do not increase the dose on your own.

References

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Last Updated on: 25 Nov 2025 | 01:02 AM (IST)

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Disclaimer

The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.