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Ursodeoxycholic Acid / Ursodiol

Molecule Description

Ursodiol is a bile acid that is naturally present in small quantities in our bo

dy. It is used in the treatment of gallstones and primary biliary cirrhosis.


Uses of Ursodeoxycholic Acid / Ursodiol

  • Gallbladder stone
  • Gallstone prevention (in obese patients who are prone to develop gallstones)
  • Primary biliary cirrhosis

Contraindications of Ursodeoxycholic Acid / Ursodiol

When should one not use Ursodeoxycholic Acid / Ursodiol

  • Do not take this medicine if you have:
  • Blockage in the bile duct
  • Allergy to any of its contents
  • Acute inflammation (redness and swelling) of gallbladder or bile duct
  • An impaired contractility of gallbladder
  • An active gastric or duodenal ulcer

Side effects of Ursodeoxycholic Acid / Ursodiol

Common side effects of this drug are:

  • Diarrhea
  • Constipation
  • Stomach pain
  • Vomiting

Precautions and Warnings of Ursodeoxycholic Acid / Ursodiol



Can I take Ursodeoxycholic Acid / Ursodiol during pregnancy?
The effect of Ursodiol on the fetus is not known. Consult your doctor if you are pregnant. Your doctor will tell you about the use of Ursodiol after assessing the benefits of it over risks.

Breast Feeding

Can I take Ursodeoxycholic Acid / Ursodiol while breastfeeding?
A small amount of medicine passes into breast milk. Limited information is available about its safety in breastfeeding, hence do not take this medicine unless considered essential by your physician.


Can I drive if I have consumed Ursodeoxycholic Acid / Ursodiol?
No information is available on the ability to drive any vehicle or use machines. However, if you observe or experience any side effects, it is advised not to drive a vehicle or use machines. Contact your doctor or pharmacist for further information.


Can I consume alcohol with Ursodeoxycholic Acid / Ursodiol?
Alcohol is better avoided as it may hinder the liver protective action of this medicine.

Other General Warnings

Talk to your doctor if
  • You have severe stomach pain, nausea and vomiting after taking this medicine
  • You have liver or kidney disease

Mode of Action of Ursodeoxycholic Acid / Ursodiol

How Does It Work?

It helps in dissolving cholesterol and prevents its production in the liver and absorption from the intestine, thereby preventing gallstones. It also decreases the level of elevated bile acids that ma...
Read more

Interactions of Ursodeoxycholic Acid / Ursodiol

Interactions with other medicines

  • Estrogen preparations reduce the efficacy of Ursodiol
  • Do not consume any acidity medication that contains aluminium or lipid-lowering compounds like Cholestyramine or Colestipol (which are bile acid sequestrants) an hour before or two hours after taking ...
    Read more
  • Cyclosporine
  • Ciprofloxacin
  • Rosuvastatin

Interactions with food items

No information is available on interactions of Ursodiol when taken with food, consult your doctor or pharmacist for further details.

Dietary Restrictions of Ursodeoxycholic Acid / Ursodiol

No information is available on dietary restrictions while you are taking Ursodiol, consult your doctor or pharmacist for further details.

Dosage of Ursodeoxycholic Acid / Ursodiol


In case you overdose, you may experience diarrhea. You must contact your physician immediately or visit the nearest medical emergency centre.

Missed a Dose

If you miss a dose, take it once you recollect. If it is almost time for the next dose, then skip the missed dose and continue with the routine dosage.

Content Details


Dr. Arpit Verma

MBBS, MD (Pharmacology)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What should be discussed with my health care expert before I start the medication of Ursodiol?

  • Tell the doctor if you are pregnant, breastfeeding or planning a pregnancy
  • Inform him if you are allergic to any food or medicinal substance
  • Inflammation of the gallbladder, bile duct, or pancreas should be reported or if suspected should be discussed with your doctor
  • Ursodiol can interact with many other medicines. Hence, the doctor needs to know about all the medications that you are consuming
Last Updated on: 24 Dec 2020 | 01:48 PM (IST)

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