Tibolone is a synthetic steroid medicine used for Hormone Replacement Therapy (HRT). It mimics the activity of the female sex hormones estrogen and progesterone and the androgen testosterone in the body.
Uses of Tibolone
This medicine is used to relieve the symptoms of estrogen deficiency (hot flushes, depression, decreased sex drive), in women who have gone through the menopause. It is also used to prevent osteoporosis in women who have gone through the menopause.
Contraindications of Tibolone
When should one not use Tibolone
- Women with any history of blood clotting (arterial thromboembolic) disease including stroke, transient ischemic attack, myocardial infarction and angina, breast cancer
- Allergic to this medicine
- History of liver disease with abnormal liver enzymes
- Any vaginal bleeding
- Any blood clots in the lungs, veins
- History of any inherited blood disorders (porphyrias)
Side effects of Tibolone
Common side effects of this drug are:
- Vaginal bleeding or spotting
- Vaginal discharge
- Vaginal thrush
- Vaginal itching
- Breast tenderness
- Abnormal hair growth
- Weight gain
- Thickening of the inner lining of the uterus (called the endometrium)
Precautions and Warnings of Tibolone
Can I take Tibolone during pregnancy?
Tibolone is not recommended to use during pregnancy. It is not indicated in women who have not yet undergone menopause. Stop this medication immediately if you think you are pregnant and inform your physician.
Can I take Tibolone while breastfeeding?
It is not recommended during breastfeeding. Consult with your doctor if you are taking this medicine while breastfeeding.
Can I drive if I have consumed Tibolone?
No influence on ability to drive.
Can I consume alcohol with Tibolone?
Alcohol consumption with this medicine causes an increase in the risk of breast cancer. Avoid alcohol while on this treatment.
Other General Warnings
Talk to your doctor if
- History of excessive thickening of uterus (endometriosis)
- If you have a history of elevated blood pressure, diabetes, gallstones, migraine headaches, asthma
- You have had any history of breast cancer
- If you experience any swelling, pain in legs, sudden pain in the chest, blood clots after taking this medicine; stop the treatment immediately and inform your doctor.
Mode of Action of Tibolone
How Does It Work?
It acts similarly to the natural estrogen, progesterone and testosterone found in the body. This helps restore the balance of hormones in the body and reduces the symptoms of menopause, whether natural or otherwise.
Interactions of Tibolone
Interactions with other medicines
- Medicine used to treat tuberculosis (Rifampicin)
- Blood thinners (Warfarin)
- Medicines used to treat epilepsy (Phenobarbital)
Interactions with food items
It may interact with can broccoli, red wine, cabbage, brussels sprouts, red wine, alcohol, grapefruit juice and cigarette smoke.
Dietary Restrictions of Tibolone
No information is available on dietary restrictions while you are taking Tibolone, consult your doctor or pharmacist for further information.
Dosage of Tibolone
Seek emergency medical help if you think you have taken too much dose of this medicine. Symptoms of overdose include nausea, vomiting and vaginal bleeding in females may occur.
Missed a Dose
If you missed any doses of medicine, take it as soon as you remember. Skip the missed dose if it is time for your subsequent scheduled dose. Do not take extra medicine of medicine to make up the missed dose.
Frequently Asked Questions (FAQs)
Q: What should I discuss with my healthcare expert before taking this medicine?
A: You should not use this medicine if you are allergic to it, tell the list of medications you are using and discuss your health condition with your doctor before taking medicine.
Q: When and how to consume medicine?
A: This medicine may be taken with or without food with a glass of water. It should be taken at the same time each day.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)
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