Teneligliptin+Dapagliflozin+Metformin Hydrochloride

Uses	Type 2 diabetes mellitus
Therapy	Anti-Diabetic
Side Effects	Headache, dizziness, low blood sugar, rashes, painful urination

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Molecule Description

Teneligliptin+Dapagliflozin+Metformin Hydrochloride is a combination medicine that helps manage type 2 diabetes by controlling blood sugar levels. It works in three ways: dapagliflozin helps remove excess sugar through urine, metformin lowers sugar production in the liver and improves the body's response to insulin, and teneligliptin increases natural hormones that help release insulin after meals and reduce sugar production. Together, these actions help keep blood sugar within a healthy range. The medicine is taken with water exactly as advised by your doctor. Taking it at the same time every day helps maintain steady blood sugar control, and skipping doses or changing the dose without guidance may affect its effectiveness. Regular monitoring of blood sugar is important, especially if you are taking other diabetes medicines. Some people may experience side effects such as headache, dizziness, mild low blood sugar, rashes, or painful urination. Long-term use of metformin may reduce vitamin B12 absorption, so occasional monitoring may be advised. Certain medicines and alcohol can interact with Teneligliptin+Dapagliflozin+Metformin Hydrochloride, affecting blood sugar levels or increasing side effects. This medicine should be used with caution in people with serious liver or heart problems, irregular eating habits, or a history of bowel or heart rhythm issues. Maintaining a balanced diet, regular activity, and monitoring for unusual symptoms such as severe dizziness, low blood sugar, or abdominal pain can help ensure safe and effective treatment.

Uses

Teneligliptin+Dapagliflozin+Metformin Hydrochloride is used for the management of type 2 diabetes mellitus in adults whose blood sugar levels are not adequately controlled by metformin alone.

Contraindications

When should one not use Teneligliptin+Dapagliflozin+Metformin Hydrochloride

If you are allergic to teneligliptin, metformin, dapagliflozin or any other ingredient of Teneligliptin+Dapagliflozin+Metformin Hydrochloride.
If you have type 1 diabetes, diabetic ketoacidosis, diabetic coma, or a past history of diabetic coma.
If you have a severe infection, are undergoing major surgery, or have experienced serious trauma, as blood sugar control in these situations is usually managed with insulin rather than this medicine.

Side effects

Common side effects of this drug are:

Headache
Dizziness
Low blood sugar
Rashes
Painful urination

Precautions and Warnings

Pregnancy

No, Teneligliptin+Dapagliflozin+Metformin Hydrochloride is not routinely recommended during pregnancy. Its safety during pregnancy has not been well established, and it should be used only if the potential benefit clearly outweighs the possible risk to the unborn baby. Always consult your doctor to evaluate safer alternatives and decide the most appropriate treatment during pregnancy.

Breast Feeding

No, Teneligliptin+Dapagliflozin+Metformin Hydrochloride should be avoided while breastfeeding. Studies have shown that the medicine can pass into breast milk, and its safety in breastfed infants has not been established. Your doctor will assess the benefits of treatment against potential risks and may advise stopping the medicine or breastfeeding to ensure safety.

Driving

Yes, you can usually drive after taking Teneligliptin+Dapagliflozin+Metformin Hydrochloride, as it does not commonly cause drowsiness or affect alertness. However, if you experience symptoms such as dizziness, low blood sugar, blurred vision, or weakness, avoid driving and consult your doctor.

Alcohol

Alcohol should not be used together with Teneligliptin+Dapagliflozin+Metformin Hydrochloride as it may cause complications like diabetic ketoacidosis.

Other General Warnings

Talk to your doctor if

You have advanced liver problems, as the safety of this medicine is not well established in severe liver failure.
You have severe heart failure (NYHA class III or IV) or other serious heart conditions.
You have pituitary or adrenal gland problems, poor nutrition, irregular eating habits, prolonged fasting, severe weakness, intense physical activity, or excess alcohol intake, as these may increase the risk of low blood sugar.
You have had abdominal surgery or a history of bowel blockage, as this medicine may worsen bowel-related problems.
You have heart rhythm problems, a very slow heartbeat, low potassium levels, congenital long QT syndrome, a history of serious rhythm disorders such as Torsades de pointes, or are using medicines for heart rhythm control.
You are taking medicines that increase insulin release, such as sulfonylureas, as using them together may increase the risk of severe low blood sugar.

Mode of Action

How Does It Work?

Dapagliflozin reduces blood glucose levels by increasing urinary glucose excretion.
Metformin reduces glucose absorption from food and glucose production by the liver, while increasing the body's response to insulin.
Teneligliptin works by increasing natural hormones that help release insulin after meals and reduce sugar production by the liver, helping to control blood sugar levels.

Interactions

Interactions with other medicines

Medicines such as beta-blockers or MAO inhibitors may increase the blood sugar-lowering effect and raise the risk of low blood sugar, while steroids or thyroid hormones may reduce the glucose-lowering effect.
Concomitant use with ketoconazole can increase teneligliptin levels in the blood, which may increase the risk of side effects.
Certain medicines taken with metformin, such as amiloride, digoxin, morphine, procainamide, quinidine, ranitidine, or vancomycin, may reduce metformin elimination and increase the risk of lactic acidosis.
Use with furosemide may increase metformin levels in the blood and reduce furosemide levels, so monitoring may be required.
Long-term use of metformin may reduce vitamin B12 absorption and, in rare cases, lead to deficiency.
Nifedipine may increase the absorption of metformin, leading to higher blood levels of metformin.
Danazol may increase blood glucose levels, and dose adjustment or closer blood sugar monitoring may be necessary.

Interactions with food items

Excessive alcohol intake should be avoided, as it may increase the risk of low blood sugar and lactic acidosis, especially with metformin.
A balanced diet with consistent carbohydrate intake helps maintain better blood sugar control while on this therapy.

Dosage

Overdose

If you think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital.

Missed a Dose

If you miss any dose of Teneligliptin+Dapagliflozin+Metformin Hydrochloride, take it as soon as you remember with food. However, if it is time for the next dose, then skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Frequently Asked Questions (FAQs)

On its own, Teneligliptin+Dapagliflozin+Metformin Hydrochloride usually has a low risk of causing low blood sugar, but the risk may increase if taken with other diabetes medicines like sulfonylureas or insulin.

Teneligliptin+Dapagliflozin+Metformin Hydrochloride is used to help control blood sugar levels in adults with type 2 diabetes, along with proper diet and exercise.