Silodosin
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Molecule Description
Silodosin is used for the treatment of problems arising due to the enlargement of the prostate gland, a medical condition known as benign prostatic hyperplasia (BPH). It blocks the alpha receptors present on walls of arteries and certain types of muscle (e.g. prostate) and causes them to relax. The primary function of alpha receptors is to narrow (constrict) and increase the pressure. Silodosin belongs to a group of medicines called ‘anti-adrenergic agents. Dizziness, postural hypotension (a drop in blood pressure after a change of posture), headache, loose motions, and retrograde ejaculation (backward flow of semen/orgasm with less or no semen) are some of the common side effects of Silodosin, but not everybody gets them.
Uses
For the treatment of enlargement of the prostate gland, a medical condition known as benign prostatic hyperplasia (BPH).
Contraindications
When should one not use Silodosin
- This medicine should not be taken in patients with allergic reaction to Silodosin
- Other alpha-receptor blockers (e.g. Prazosin, Doxazoin, Terazosin), or any of its components
- It is not to be used in liver diseases, in patients having low blood pressure or those on Diuretics
- Severe kidney disease
Side effects
Common side effects of this drug are:
- Retrograde ejaculation
- Dizziness
- Postural hypotension
- Headache
- Loose motions
- Nasal congestion
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- As Silodosin works by slowing the heart rate, older adults may be more sensitive to the side effects of this medicine, especially dizziness and low blood pressure when getting up from a sitting or lying position
- Silodosin must be used with caution in elderly patients and people with liver disease
- People undergoing cataract surgery should inform their doctor as Silodosin may sometime complicate the procedure
Mode of Action
How Does It Work?
Silodosin helps relax the muscles in the prostate and in the opening to the bladder. This may help increase the flow of urine or decrease the symptoms. This medicine is usually given only to men.
Interactions
Interactions with other medicines
- Other alpha-receptor blockers - Terazosin, Prazosin, Alfuzosin, Tamsulosin, Doxazosin
- Medicines used to treat HIV/ AIDS (Fosemprenavir, Atazanavir, Indinavir)
- Antifungals (Clotrimazole)
- Antibiotics (Clarithromycin, Dalfopristin/ Quinupristin, Erythromycin)
- Isoniazid (and antitubercular treatment containing Isoniazid as one of the medicines)
- Imanitib
- Blood pressure medications (Diltiazem, Felodipine, Nicardipine, Nifedipine, Verapamil, etc.)
- Medicines used to suppress the immune system/ prevent organ transplant rejection (Cyclosporine, Sirolimus, Tacrolimus)
- Medicines used to treat erectile dysfunction (Sildenafil, Tadalafil, Vardenafil)
- Quinidine (used to treat irregular heartbeats)
- Conivaptan (used to treat low sodium levels)
Frequently Asked Questions (FAQs)
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