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Silodosin

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Molecule Description

Silodosin is used for the treatment of problems arising due to the enlargement of the prostate gland, a medical condition known as benign prostatic hyperplasia (BPH). It blocks the alpha receptors present on walls of arteries and certain types of muscle (e.g. prostate) and causes them to relax. The primary function of alpha receptors is to narrow (constrict) and increase the pressure. Silodosin belongs to a group of medicines called ‘anti-adrenergic agents. Dizziness, postural hypotension (a drop in blood pressure after a change of posture), headache, loose motions, and retrograde ejaculation (backward flow of semen/orgasm with less or no semen) are some of the common side effects of Silodosin, but not everybody gets them.

Uses

For the treatment of enlargement of the prostate gland, a medical condition known as benign prostatic hyperplasia (BPH).

Contraindications

When should one not use Silodosin

  • This medicine should not be taken in patients with allergic reaction to Silodosin
  • Other alpha-receptor blockers (e.g. Prazosin, Doxazoin, Terazosin), or any of its components
  • It is not to be used in liver diseases, in patients having low blood pressure or those on Diuretics
  • Severe kidney disease

Side effects

Common side effects of this drug are:

  • Retrograde ejaculation
  • Dizziness
  • Postural hypotension
  • Headache
  • Loose motions
  • Nasal congestion

Precautions and Warnings

Pregnancy

Pregnancy

This medicine is for use in males only.

Breast Feeding

Breast Feeding

This medicine is for use in males only.

Driving

Driving

Silodosin may cause dizziness, lightheadedness or fainting; hence, caution is advised while driving. Do not drive any vehicle in the first few weeks after starting the medication and later on, do not drive for long distances.

Alcohol

Alcohol

Drinking alcohol with Silodosin may increase the risk of side effects so this is not recommended.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • As Silodosin works by slowing the heart rate, older adults may be more sensitive to the side effects of this medicine, especially dizziness and low blood pressure when getting up from a sitting or lying position
  • Silodosin must be used with caution in elderly patients and people with liver disease
  • People undergoing cataract surgery should inform their doctor as Silodosin may sometime complicate the procedure

Mode of Action

How Does It Work?

Silodosin helps relax the muscles in the prostate and in the opening to the bladder. This may help increase the flow of urine or decrease the symptoms. This medicine is usually given only to men.

Interactions

Interactions with other medicines

  • Other alpha-receptor blockers - Terazosin, Prazosin, Alfuzosin, Tamsulosin, Doxazosin
  • Medicines used to treat HIV/ AIDS (Fosemprenavir, Atazanavir, Indinavir)
  • Antifungals (Clotrimazole)
  • Antibiotics (Clarithromycin, Dalfopristin/ Quinupristin, Erythromycin)
  • Isoniazid (and antitubercular treatment containing Isoniazid as one of the medicines)
  • Imanitib
  • Blood pressure medications (Diltiazem, Felodipine, Nicardipine, Nifedipine, Verapamil, etc.)
  • Medicines used to suppress the immune system/ prevent organ transplant rejection (Cyclosporine, Sirolimus, Tacrolimus)
  • Medicines used to treat erectile dysfunction (Sildenafil, Tadalafil, Vardenafil)
  • Quinidine (used to treat irregular heartbeats)
  • Conivaptan (used to treat low sodium levels)

Frequently Asked Questions (FAQs)

You cannot take Silodosin if you are allergic to it or other medicines of the same group (alpha-receptor blockers) like Prazosin, Terazosin, Doxazosin, etc.Inform your physician if you have severe kidney or liver diseaseIf you have low blood pressure and heart diseaseIf you are on a low salt dietIf you are taking any water pill (Diuretic)If you have had a history of prostate cancer

Prostate is a gland (a secretory organ) that is present between the penis and the bladder. Its primary function is to nourish and transport the semen (male ejaculatory fluid) during the reproductive ageAs old age approaches, the prostate gland enlarges in some men due to decreased reproductive hormones and this will lead to inadequate nourishment and enlargement of the glandThe prostate can also enlarge in Prostate cancer and hence the name Benign Prostatic Hyperplasia to differentiate it from cancerBenign means ‘not malignant (cancerous)’

To avoid injury from dizziness or fainting, your doctor may advise you to take your first dose of silodosin with food at bedtime so that your body can adjust to its effects. The dosage is determined by your medical condition and response to treatment. Take this medication on a regular basis to get the most out of it.

Silodosin helps relax the muscles in the prostate and in the opening to the bladder. This may help increase the flow of urine or decrease the symptoms. This medicine is usually given only to men.

Silodosin is a medication used to treat lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). It is a selective alpha-1 adrenergic receptor blocker that works by relaxing the muscles in the prostate gland and bladder. The most common side effects of silodosin are: Dizziness, lightheadedness, or fainting, especially when getting up suddenly from a sitting or lying position Ejaculation problems, such as decreased semen volume or retrograde ejaculation Diarrhea Stuffy or runny nose

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