Pyrazinamide is an anti-tuberculosis medicine that works by killing or preventi
ng the growth of bacteria that causes tuberculosis (commonly called TB).
Uses of Pyrazinamide
This medicine is used to treat tuberculosis. It is an antibiotic that treats only bacterial infections. Pyrazinamide is always given in combination with other anti-tuberculosis agents.
Contraindications of Pyrazinamide
When should one not use Pyrazinamide
- Severe liver damage
- Gout or abnormal high amount of uric acid in blood
- Habit of drinking too much of alcohol
- Allergic reaction to this medicine and any of its components
- Condition in which high porphyria seen in blood and urine
Side effects of Pyrazinamide
Common side effects of this drug are:
- Stomach upset
- Loss of appetite
- Mild muscle or joint pain
Precautions and Warnings of Pyrazinamide
Can I take Pyrazinamide during pregnancy?
This medication should be used only with the doctor's prescription.
Can I take Pyrazinamide while breastfeeding?
This medicine passes into breast milk and effects on a nursing infant. Hence it is not recommended during breastfeeding.
Can I drive if I have consumed Pyrazinamide?
There are no adequate evidences of this medicine regarding this aspect.
Can I consume alcohol with Pyrazinamide?
Alcoholic beverages should be avoided while doing this medication. It may increase the risk of liver disease.
Other General Warnings
Talk to your doctor if
- If you have kidney disease
- If you are diabetic
- If you suffer from lactose intolerance
- If any immunizations/ vaccinations while following Pyrazinamide medication, unless your doctor asks you to do so
Mode of Action of Pyrazinamide
How Does It Work?
This medicine stops the growth of organism mycobacterium tuberculosis. It reaches the site of infection where the tuberculosis bacteria releases chemicals and inhibits its action and thereby preventing the growth of these bacteria....
Interactions of Pyrazinamide
Interactions with other medicines
This medicine has interactions with many medicines such as: Leflunomide, Teriflunomide, BCG vaccine, cholera vaccine, Isoniazid, Rifampicin, Lomitapide, Mipomersen, Brentuximab, Efavirenz, Tenofvir, Indium Oxyquinoline–III, Interferon Beta-1a, Bupropion, Clofarabine, Cyclosporine, Naltrexone, Epirubicin, Methotrexate, Morphine, Idelalisib, Allupurinol, etc....
Interactions with food items
This medicine has interactions with food like aged cheese, few types of fish, dried meat, etc.
Dietary Restrictions of Pyrazinamide
You may need to avoid certain foods while you are taking Pyrazinamide. It includes red wine, aged cheese, dried meats and tuna or any other fish.
Dosage of Pyrazinamide
If anyone has overdosed with Pyrazinamide, one can suffer from breathing problems. Sputum test, kidney/ liver function, uric acid levels, complete blood count should be performed periodically.
Missed a Dose
If you miss a dose, take it as quick as possible. If it is near the time of the next dose, skip it and do not double the dose.
Dr. Mansi Savla
B. Pharm, PharmD
Dr. Ritu Budania
MBBS, MD (Pharmacology)
Frequently Asked Questions (FAQs)
Q: What should I discuss with my healthcare expert before taking this medicine?
A: Give a detailed account of your medical and surgical history. Also, mention to your doctor all the prescription and non-prescription medicines, herbal preparations and nutritional supplements that you may be taking before starting this medication.
Q: When and how to consume the medicine?
A: Take this medicine with a sufficient glass of water, with or without food.
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