Prucalopride

Uses	Constipation
Therapy	Laxative
Side Effects	Headache, feeling sick, diarrhoea, abdominal pain, decreased appetite

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Molecule Description

Prucalopride is used in the treatment of constipation. Constipation is a condition characterised by difficult, infrequent and/or incomplete defecation. It works by enhancing the motility of the gut and facilitates defecation. While taking this medicine consume enough fibre such as fruits, vegetables and grains rich in fibre. Talk with your health care professional to suggest a customised diet to fit your lifestyle.

Uses

For the treatment of constipation of unknown origin or known cause.

Contraindications

When should one not use Prucalopride

If you are allergic to prucalopride or any of the other ingredients of Prucalopride.
If you are on dialysis, have perforation or obstruction of the gut wall or have intestinal diseases.

Side effects

Common side effects of this drug are:

Headache
Feeling sick
Diarrhoea
Abdominal pain
Decreased appetite

Precautions and Warnings

Pregnancy

Prucalopride should not be taken during pregnancy. Tell your doctor if you are pregnant or planning pregnancy before initiating the treatment. While taking this medicine use an effective contraceptive.

Breast Feeding

Breastfeeding is not recommended while on treatment with this medicine.

Driving

Prucalopride doesn't affect your driving abilities. However, you may feel tired and dizzy during the first few days of treatment. Avoid driving if affected.

Alcohol

There is no known interaction between alcohol and Prucalopride.

Other General Warnings

Talk to your doctor if

You have liver or kidney-related problems.
You have any disorder related to the heart, lung and endocrine system.
You have neurological or psychiatric disorders.
You have cancer or AIDS.
You experience severe diarrhoea after taking this medicine.

Mode of Action

How Does It Work?

Prucalopride belongs to a class of medicines that increases the motility of the gut. It acts on the muscle wall of the gut, helping to restore the normal functioning of the bowel.

Interactions

Interactions with food items

Prucalopride can be taken with or without food. However, it is often recommended to take it with or just after a meal to help reduce gastrointestinal side effects such as nausea and abdominal discomfort.

Dosage

Overdose

Symptoms of an overdose of Prucalopride include nausea, diarrhoea and headache. Seek immediate medical help. In case you experience diarrhoea, consume plenty of water/liquid.

Missed a Dose

Skip the missed dose and do not take a double dose to make up for a forgotten dose. Just take your next dose at the usual time.

Frequently Asked Questions (FAQs)

Prucalopride is used for the treatment of chronic idiopathic constipation. It is a type of constipation wherein the underlying cause of constipation is not known. This medicine is prescribed when other laxatives fail to provide adequate relief.

Constipation can happen due to various reasons, most common among them are the slow movement of stool in the colon, delayed defecation, functional disease of the gut and irritable bowel disease. The disease of brain, spinal cord, metabolic disorders, blockage or obstruction in the gut, etc. It can also happen due to certain medicines, supplements, lifestyle changes (travelling, old age, pregnancy) and due to specific dietary habits (not consuming enough fibre, drinking sufficient water and not doing enough exercise).

No, Prucalopride is not a laxative. It belongs to a class of medicines that increases the motility of the gut. It is used in the treatment of chronic constipation in adults, in whom laxatives do not respond well.

Prucalopride can be taken at any time of the day or as advised by the doctor. Try to take it regularly for a specified duration to get maximum effect.

It usually starts working within 2 to 4 hours. It varies depending on the physiological condition of an individual and varies among different individuals. Otherwise, it may take about 4-5 days to show complete effect and rapid bowel movements.

Headache, nausea, diarrhoea or abdominal pain are a few common side effects of Prucalopride. However, these symptoms often improve as your body adjusts to the new medicine.

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