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Molecule Description

Nicotine is used for Nicotine Replacement Therapy (NRT) for people with smoking addiction. It is available a transdermal patch, chewing gums, nasal inhaler spray and tablets. Using a controlled amount of nicotine helps to reduce the withdrawal symptoms when you quit smoking.
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Uses of Nicotine

  • To quit smoking
  • To quit tobacco chewing habit

Contraindications of Nicotine

When should one not use Nicotine

  • Heart disease
  • Heart rhythm disorder
  • High blood pressure
  • Diabetes
  • Stomach ulcer
  • Seizures
  • Allergy to Nicotine

Side effects of Nicotine

Common side effects of this drug are:

  • Sleep disturbances and vivid dreams
  • Nicotine gum and lozenges may cause heartburn, hiccups and nausea
  • Nicotine nasal spray and inhaler may cause throat irritation, runny nose, sneezing and coughing
  • Nicotine patch may cause skin irritation

Precautions and Warnings of Nicotine


Can I take Nicotine during pregnancy?
Nicotine and smoking may harm your unborn baby. If you are pregnant, try to stop smoking without using nicotine. During pregnancy, this medication should be used if and only when prescribed by the doctor.

Breast Feeding

Can I take Nicotine while breastfeeding?
Nicotine from smoking and this medicine passes into breast milk and could have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.


Can I drive if I have consumed Nicotine?
Using this medicine is not known to affect your ability to drive or use machines.


Can I consume alcohol with Nicotine?
Avoid the consumption of alcoholic beverages when taking Nicotine Replacement Therapy.

Other General Warnings

Talk to your doctor if
  • Take the dose of this medicine strictly as prescribed by your doctor
  • Do not alter the dosage in any case by yourself
  • Tell your doctor if you have diabetes
  • Monitor your blood sugar levels more often when you start using this medicine
  • Doctor may adjust the dose of Insulin you take
  • All your ongoing medicines

Mode of Action of Nicotine

How Does It Work?

Nicotine can help you to quit smoking by replacing Nicotine in cigarettes. When you stop smoking, nicotine levels in the body drop suddenly, causing withdrawal symptoms like nervousness, irritability, headache and weight gain. Nicotine is given in such cases to avoid a sudden drop in blood-nicotine levels and thus prevents withdrawal reaction. A gradual tapering of nicotine replacement helps you to overcome smoking or tobacco addiction completely.
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Interactions of Nicotine

Interactions with other medicines

  • Medicines for high blood pressure (e.g.,beta-blockers such as Labetalol, Prazosin)
  • Bronchodilators/ decongestants (such as Isoproterenol,  Phenylephrine )
  • If you stop smoking, it can change the way the liver removes certain medicines from your body (e.g. Acetaminophen, Caffeine, Insulin, Oxazepam, Pentazocine,  Propoxyphene, Propranolol, Theophylline)
  • Tricyclic antidepressants such as Amitriptyline/ Imipramine
  • Water pills/ Diuretics such as Furosemide

Interactions with food items

No interactions specified.

Dosage of Nicotine


Symptoms of overdose can be lethal. Burning of the mouth and throat, nausea, vomiting, excess salivation, abdominal pain, diarrhea, sweating, headache, dizziness, hearing and visual disturbances, weakness, confusion, syncope, extreme tiredness, breathing difficulty, rapid heartbeats (and fast or weak or irregular pulse), low blood pressure, fits, respiration failure, coma. Seek emergency medical care immediately.
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Missed a Dose

Skip the missed dose if it is almost the time for the next scheduled dose. Do not take extra medicine to compensate for the missed dose.

Content Details


Dr. Arpit Verma

MBBS, MD (Pharmacology)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What should I discuss with my healthcare expert before taking Nicotine?

A: Give a detailed account of your medical and surgical history. The doctor should also know about other health supplements like herbal medications and nutritional supplements that you may take before starting this medication.

Q: What are the precautions should I take while on this medicine?

A: The dosage regimen of medicine should be followed regularly. Any dose miscalculation will have a serious effect.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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