Naproxen

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Molecule Description

Naproxen is a painkiller with anti-inflammatory and antipyretic (fever-reducing) properties. It is used to provide relief from the pain associated with various types of arthritis such as spondylitis, rheumatoid, osteoarthritis, gout and also menstrual pain. This medicine acts by blocking the release of the chemical substance responsible for pain and inflammation. It should not be taken by children under 16 years of age and by children below 5 years of age who have had rheumatoid arthritis since birth. The most common side effects of this medicine are heartburn, nausea, vomiting. Before using this medicine, inform the doctor if you are pregnant, planning a pregnancy or breastfeeding and about your detailed medical history.

Uses

It is used to give relief from mild to moderate pain in conditions of joints, muscles and tendons; like rheumatoid arthritis, osteoarthritis, ankylosing spondylitis (a painful condition), inflammation of tendons/ joint burns, acute gout and pain before and during menstrual periods (in the absence of a disease).

Contraindications

When should one not use Naproxen

Allergic reactions in response to Ibuprofen, Aspirin or another Non-Steroidal Anti-Inflammatory/ analgesic medicine
Active or history of stomach/ intestinal ulcers or active bleeding from these ulcers
History of asthma
Urticaria
Kidney disease

Side effects

Common side effects of this drug are:

Belching, heartburn
Bruising
Difficult breathing
Feeling of indigestion
Headache
Itching to the skin or sometimes purplish patches in the skin
Pain in the chest below the breastbone
Skin eruptions
Stomach pain
Swelling and tightness in the chest
Bleeding from stomach, coffee color vomit, black stools or bloody
Diarrhea
Ulcer in stomach

Precautions and Warnings

Pregnancy

This medicine is not recommended in women attempting to conceive as it may impair female fertility. This medicine is not to be used during the last three months of pregnancy. In the first six months of pregnancy, it is used only if prescribed by your doctor.

Breast Feeding

The available data indicate that levels of Naproxen in breastmilk are low and adverse effects in breastfed infants are apparently uncommon. Please consult with your doctor. Your doctor may prescribe you a safer alternative.

Driving

This medicine may lead to dizziness. Do not drive unless you feel well.

Alcohol

Do not drink alcohol while taking Naproxen. Alcohol may lead to increase the risk of stomach bleeding caused by this medicine.

Other General Warnings

Talk to your doctor if

If you have liver disease or asthma, dose adjustment of this medicine may be needed. Please consult with your doctor
Naproxen can increase the risk of a heart attack. It occurs when there is long term or taking high doses or if you have heart disease. People without heart disease or risk factors may lead to cause a stroke or heart attack while taking this medicine. This medicine is not to be used just before or after heart bypass surgery (coronary artery bypass graft)
This medicine may lead to cause an effect of the stomach or intestinal bleeding which can be fatal. These conditions can occur without warning while you are using Naproxen, especially in the elderly
You should not use Naproxen if you are allergic to it. Discuss with your doctor if you have any such condition

Mode of Action

How Does It Work?

Prostaglandins are chemicals released in the body which cause swelling and pain. Naproxen is an inhibitor of prostaglandin synthesis. It works by reducing inflammation and also by relieving pain, swelling and stiffness in the joints and muscles.

Interactions

Interactions with other medicines

Most significant interactions with Zolpidem, Aspirin, Diphenhydramine, Duloxetine, Omega-3 Polyunsaturated fatty acids, Cyclobenzaprine, Atorvastatin and Pregabalin.

Dosage

Overdose

Inform your doctor immediately in case of an overdose. Symptoms of overdose include headache, heartburn, vomiting, nausea, epigastric pain, seizures, drowsiness, prolongation of clotting time leading to easy bruising and a higher risk of bleeding.

Missed a Dose

Take the missed dose as early as you remember. If it is almost time for your next dose, skip the missed dose & do not take extra medicine for the missed dose.

Frequently Asked Questions (FAQs)

Naproxen can increase the risk of heart attack. It occurs when it is taken for a for long term, if you are taking high doses or if you have heart disease. People without heart disease or risk factors may lead to cause a stroke or heart attack while taking this medicine. This medicine is not to be used just before or after heart bypass surgery (coronary artery bypass graft). This medicine may lead to cause an effect of the stomach or intestinal bleeding which can be fatal. These conditions can occur without warning while you are using Naproxen, especially in the elderly. You should not continue the use this if you are allergic to Naproxen. Discuss with your doctor if you have any such condition. Also, tell your doctor about all your ongoing medications.

Tablet/Capsule: Take orally with a full glass of water, take with food or milk if you occur with stomach upsetOral Suspension: Shake gently before use. Use with the dosing device providedControlled and delayed-release tablets: Do not break, crush or chew the tablet

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