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Milnacipran

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Molecule Description

Milnacipran is used in the treatment of chronic pain caused by Fibromyalgia although it works as an antidepressant.

Uses

  • Chronic pain caused by Fibromyalgia (that affects the muscles, tendons, ligaments and supporting tissues)
  • Depression

Contraindications

When should one not use Milnacipran

  • It is advisable to avoid taking Milnacipran in:
  • If you are allergic to this medicine
  • Child below 18 yrs of age
  • Kidney disease
  • Heart disease, high BP
  • Blood cell disorder e.g. sickle cell or haemophilia
  • Glaucoma
  • Low sodium levels in the body
  • Problems in urination
  • Bipolar disorder
  • Liver disorder
  • Convulsions or epilepsy

Side effects

Common side effects of this drug are:

  • Nausea, vomiting
  • Dry mouth
  • Constipation
  • Increased sweating
  • Headache
  • Dizziness
  • Insomnia
  • High blood pressure
  • Serious side effects:
  • Allergic symptoms - itching, hives, rash, swelling of lips, face, etc.
  • Liver complaints – stomach pain, nausea, vomiting, jaundice, dark urine
  • Blurred vision, tunnel vision
  • Convulsion
  • Easy bruising, bleeding
  • Manic episodes – increased energy, extreme happiness, talkative etc.
  • High serotonin signs - hallucination, fever, agitation, nausea, vomiting, diarrhea, fainting, etc.
  • Low sodium signs – headache, confusion, slurred speech, loss of coordination, severe weakness, etc.
  • High BP – severe headache, chest pain, breathlessness, irregular heartbeats, nosebleed, etc.

Precautions and Warnings

Pregnancy

Pregnancy

It is advisable to avoid taking Milnacipran during pregnancy. It may affect the unborn baby.

Breast Feeding

Breast Feeding

It is not recommended in breastfeeding. It is still not known if it passes into breast milk. Doctor's consultation is advised.

Driving

Driving

It may impair your thinking or reactions and this in turn, may affect your ability to drive. Be cautious while driving if you are on this medication.

Alcohol

Alcohol

Milnacipran may cause excessive drowsiness and calmness with alcohol. It may worsen existing liver damage. It is advised to avoid excess intake of alcohol with this medicine.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You notice abrupt mood changes or develop suicidal thoughts
  • You have any liver, kidney or heart problems
  • You have any psychiatric conditions or you're on a medication for that

Mode of Action

How Does It Work?

This medicine is Serotonin-Norepinephrine Reuptake Inhibitor (SNRI). It works by helping to restore the balance of certain natural substances present in the brain (neurotransmitters), thereby reducing the pain and assisting in the management of Fibromyalgia. It is also used in the management of depression.

Interactions

Interactions with other medicines

  • Narcotic pain medicine, sleeping pills, muscle relaxants, medicine for anxiety, depression, fits, etc.
  • Certain medicine, when taken along with Milnacipran, can cause Serotonin syndrome – e.g., Medicine for Parkinson’s disease, migraine, ADHD, etc.
  • Blood thinners e.g., Warfarin

Interactions with food items

No adequate information.

Dosage

Overdose

  • The symptoms of overdose can be – slow heart rate, weak pulse, fainting, slow breathing, etc.
  • Seek medical emergency help in case of overdose

Missed a Dose

If you miss a dose, take medicine when you remember the missed dose. If it is almost time for your next dose, don’t take the missed dose and go back to the regular dosing schedule. Do not take a double dose.

Frequently Asked Questions (FAQs)

Inform the doctor about your detailed medical & surgical historyInform your physician if you have any of the following conditions - Liver diseaseKidney diseaseHeart disease, high BPBlood cell disorder e.g. sickle cell or haemophiliaGlaucomaLow sodium levels in the bodyProblems in urinationIf you drink alcoholIf you are taking blood thinners, e.g. warfarinIf you are pregnant, lactating or planning a pregnancy

About 58% of medicine is removed through urine.

Half-life of this medicine is around 8-10 hours; hence, it can stay up to 16-20 hours in the body.

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