Milnacipran
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Regulated
Molecule Description
Milnacipran is used in the treatment of chronic pain caused by Fibromyalgia although it works as an antidepressant.
Uses
- Chronic pain caused by Fibromyalgia (that affects the muscles, tendons, ligaments and supporting tissues)
- Depression
Contraindications
When should one not use Milnacipran
- It is advisable to avoid taking Milnacipran in:
- If you are allergic to this medicine
- Child below 18 yrs of age
- Kidney disease
- Heart disease, high BP
- Blood cell disorder e.g. sickle cell or haemophilia
- Glaucoma
- Low sodium levels in the body
- Problems in urination
- Bipolar disorder
- Liver disorder
- Convulsions or epilepsy
Side effects
Common side effects of this drug are:
- Nausea, vomiting
- Dry mouth
- Constipation
- Increased sweating
- Headache
- Dizziness
- Insomnia
- High blood pressure
- Serious side effects:
- Allergic symptoms - itching, hives, rash, swelling of lips, face, etc.
- Liver complaints – stomach pain, nausea, vomiting, jaundice, dark urine
- Blurred vision, tunnel vision
- Convulsion
- Easy bruising, bleeding
- Manic episodes – increased energy, extreme happiness, talkative etc.
- High serotonin signs - hallucination, fever, agitation, nausea, vomiting, diarrhea, fainting, etc.
- Low sodium signs – headache, confusion, slurred speech, loss of coordination, severe weakness, etc.
- High BP – severe headache, chest pain, breathlessness, irregular heartbeats, nosebleed, etc.
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You notice abrupt mood changes or develop suicidal thoughts
- You have any liver, kidney or heart problems
- You have any psychiatric conditions or you're on a medication for that
Mode of Action
How Does It Work?
This medicine is Serotonin-Norepinephrine Reuptake Inhibitor (SNRI). It works by helping to restore the balance of certain natural substances present in the brain (neurotransmitters), thereby reducing the pain and assisting in the management of Fibromyalgia. It is also used in the management of depression.
Interactions
Interactions with other medicines
- Narcotic pain medicine, sleeping pills, muscle relaxants, medicine for anxiety, depression, fits, etc.
- Certain medicine, when taken along with Milnacipran, can cause Serotonin syndrome – e.g., Medicine for Parkinson’s disease, migraine, ADHD, etc.
- Blood thinners e.g., Warfarin
Interactions with food items
No adequate information.
Dosage
Overdose
- The symptoms of overdose can be – slow heart rate, weak pulse, fainting, slow breathing, etc.
- Seek medical emergency help in case of overdose
Missed a Dose
If you miss a dose, take medicine when you remember the missed dose. If it is almost time for your next dose, don’t take the missed dose and go back to the regular dosing schedule. Do not take a double dose.
Frequently Asked Questions (FAQs)
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