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Hydroxychloroquine Sulphate

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Molecule Summary

Uses
Immune system disorders
Therapy
Drugs For Rheumatoid Arthritis
Side Effects
Stomach pain, nausea, vomiting, diarrhoea, loss of appetite, headache
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Molecule Description

Hydroxychloroquine Sulphate is used to treat immune system disorders such as Systemic lupus erythematosus (SLE) and rheumatoid arthritis. Hydroxychloroquine Sulphate should be taken as per the directions given by the doctor and for the exact duration as prescribed. It should be taken after a meal or with a glass of milk. Do not stop taking Hydroxychloroquine Sulphate abruptly. The common side effects of this medicine are stomach pain, nausea, vomiting, diarrhoea, headache and dizziness. Most of these are temporary but if you feel the side effects persist or your condition worsens, then immediately contact your doctor.

Uses

Hydroxychloroquine Sulphate is used in the treatment of Systemic lupus erythematosus (SLE), an immune system disorder in which the immune system attacks its own body tissues, rheumatoid arthritis (swelling and pain in joints) and skin rash due to sun exposure.

Contraindications

When should one not use Hydroxychloroquine Sulphate

  • Do not use Hydroxychloroquine Sulphate if you are allergic to Hydroxychloroquine or any of the other ingredients of this medicine.
  • Do not use it if you are allergic to chloroquine.
  • Do not use it if you are suffering from an eye disease called maculopathy, usually characterised by visual abnormalities.

Side effects

Common side effects of this drug are:

  • Stomach pain
  • Nausea
  • Vomiting
  • Diarrhoea
  • Loss of appetite
  • Headache
  • Dizziness
  • Mood swings
  • Rashes on the Skin
  • Pigmentation on the skin
  • Blurred vision, unable to recognise colours and other eye disorders. If this happens, immediately stop taking this medicine and inform your doctor
  • Sudden severe fall in blood glucose, one may experience anxiety, sweating, hunger pangs, headaches, irritability or fainting

Precautions and Warnings

Pregnancy

Pregnancy

Hydroxychloroquine Sulphate may cause harmful effects in unborn babies. Therefore, it is not recommended during pregnancy. Consult your doctor before starting any medicine if you are pregnant or think you may be pregnant or are planning to have a baby.

Breast Feeding

Breast Feeding

Hydroxychloroquine passes into the breastmilk. Women taking Hydroxychloroquine Sulphate should not breastfeed as newborns are very sensitive to the harmful effects of this medicine. It is essential to consult the doctor before using any medication while breastfeeding.

Driving

Driving

You may experience visual disturbances, impaired ability to recognise objects properly & dizziness while on treatment with Hydroxychloroquine Sulphate. Hence, avoid driving if you do not feel well or are unable to be alert.

Alcohol

Alcohol

You should avoid consuming alcohol while taking Hydroxychloroquine Sulphate as it may worsen the side effects of this medicine.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You experience visual disturbances or have any existing eye disorders. Before beginning treatment with this medicine, you should undergo an eye examination.
  • You experience a sudden drop in blood sugar and unconsciousness, monitoring of blood glucose is recommended if you are a diabetic.
  • Hydroxychloroquine Sulphate may cause abnormal or irregular heartbeats. Your doctor shall conduct an ECG before starting treatment with this medicine, inform your doctor if you already have heart disease.
  • You have liver or kidney diseases, you may require dose adjustment.
  • You have stomach disease.
  • You develop swelling in the legs, breathlessness, fatigue, bloating and coughing while lying down.
  • You develop rashes after taking this medicine.
  • You have a history of a rare inherited metabolic disorder called porphyria.
  • You are supposed to take this medicine for long-term treatment. You should be monitored regularly for heart health & blood count.
  • Keep Hydroxychloroquine Sulphate away from children as even if a small amount is accidentally taken, it may cause serious side effects.

Mode of Action

How Does It Work?

Hydroxychloroquine Sulphate has anti-inflammatory and immunomodulatory action. It inhibits the action of chemicals such as prostaglandin, interleukins and other immune system modifying cells and enzymes. Therefore, relieves pain and swelling in autoimmune diseases.

Interactions

Interactions with other medicines

  • Concomitant use of medicines like Digoxin for heart disorders with Hydroxychloroquine Sulphate can increase the risk of digoxin toxicity.
  • You may experience low blood sugar when taken along with insulin or other antidiabetic medicine. Inform your doctor about all your diabetic medicines.
  • Antacids and medicines used to stop diarrhoea should be taken with a minimum gap of four hours when used together with Hydroxychloroquine Sulphate.
  • You may experience irregular heart rhythm if you take medicines like Amiodarone, Moxifloxacin & Halofantrine.
  • There is an increased risk of an episode of fits if you take this medicine along with antimalarials like Mefloquine.
  • Medicines used to treat muscle weakness like Neostigmine & Pyridostigmine, medicines to treat worm infections like Praziquantel, Cimetidine and Gentamicin may not work properly.
  • Medicines like Cyclosporin used for immune system disorders, Agalsidase and medicines used to treat fits should be used with caution along with Hydroxychloroquine Sulphate.

Dosage

Overdose

  • Symptoms of an overdose are headache, eyesight problems, low blood pressure, fits, irregular heartbeats, heart problems, difficulty in breathing and sometimes even heart attack.
  • If you experience any of these symptoms or if you think you have taken too much of Hydroxychloroquine Sulphate, then contact your doctor immediately or visit the nearest hospital.

Missed a Dose

You should never miss your dose, as it may interfere with the effect of this medicine. If you have missed taking any dose of Hydroxychloroquine Sulphate, then take it as soon as you remember. However, if it's time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose of this medicine to compensate for the missed one.

Frequently Asked Questions (FAQs)

No, Hydroxychloroquine Sulphate is to be taken only if it is prescribed by your doctor. Taking this medicine through self-medication can lead to harm. Before giving this medicine, your doctor shall perform an ECG to check if you have any heart ailment. Your doctor will also look at your other existing disorders, medicines and adjust the dose accordingly.

Yes, there are some serious side effects of Hydroxychloroquine Sulphate. It can cause a very severe drop in your blood sugar, which can be dangerous. It can cause heart-related side effects, which can be serious. It can cause skin peeling, blistering known as Stevens-Johnson syndrome. It can cause anaemia, low platelet count and liver enzymes being raised.

Hydroxychloroquine Sulphate is used to treat Systemic lupus erythematosus (SLE), an immune system disorder in which the immune system attacks its own body tissues. It is also used to treat Rheumatoid arthritis.

No, Hydroxychloroquine Sulphate has not shown any habit-forming tendencies.

Inform the doctor about your detailed medical & surgical history. Inform your doctor if you have skin, stomach, liver or kidney diseases and medical conditions. Inform your doctor if you are pregnant, breastfeeding or are planning to have a baby. Hydroxychloroquine Sulphate may interact with other medicines. Hence, inform your doctor if you are taking any other medications, including supplements or herbal products. Also, tell your doctor if you are stopping any medicine.

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