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Glibenclamide / Glyburide

Molecule Description

Glibenclamide is an antidiabetic medicine that belongs to the Sulfonylurea grou

p. It reduces high blood sugar level in the body. It mainly prevents postprandial blood sugar (blood sugar measured 2 hours after food). This medicine is given in Type 2 diabetes mellitus.


Uses of Glibenclamide / Glyburide

Glibenclamide is used as an anti-diabetic medicine for Type 2 diabetes in adults.

Contraindications of Glibenclamide / Glyburide

When should one not use Glibenclamide / Glyburide

  • If you have any allergic reactions to Glibenclamide
  • If you are suffering from Type 1 diabetes or ketoacidosis (caused by excessively high blood sugars in people with Type 1 diabetes)
  • If you have reduced consciousness or you are going to have any surgery
  • If you are suffering from severe kidney disease or any severe infections

Side effects of Glibenclamide / Glyburide

Common side effects of this drug are:

  • Low blood glucose levels causing fainting, sweating, and giddiness
  • Headache
  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Increase in appetite
  • Allergic skin reactions
  • Anemia
  • Weight gain
  • Elevation of liver enzyme levels
  • Water retention
  • Jaundice is rare

Precautions and Warnings of Glibenclamide / Glyburide



Can I take Glibenclamide / Glyburide during pregnancy?
Usage of this medicine in pregnant women is not recommended unless needed. Please consult with your doctor.

Breast Feeding

Can I take Glibenclamide / Glyburide while breastfeeding?
Use this medicine while breastfeeding only when needed. Please consult with your doctor.


Can I drive if I have consumed Glibenclamide / Glyburide?
If your blood sugar is not under control, then this may affect your vision or concentration level. Do not drive until you feel well.


Can I consume alcohol with Glibenclamide / Glyburide?
Too much intake of alcohol has to be avoided when you are taking this medicine for controlling blood sugar levels.

Other General Warnings

Talk to your doctor if
  • Suffer from severe kidney disease or liver problems
  • Suffering from ketoacidosis (caused by excessively high blood sugars in people with diabetes)
  • Suffering from a severe infection
  • Suffering from stress or from any condition likely to make controlling your blood sugar difficult
  • If you have undergone any surgeries
  • If you have porphyria (a disease of blood proteins affecting the skin, gut and nervous system)
  • If you have intolerance to some sugars

Mode of Action of Glibenclamide / Glyburide

How Does It Work?

In diabetes mellitus, either there is a deficiency in insulin secretion from the pancreas, or there is resistance to its action at the cellular level, sometimes even both. Glibenclamide increases insu...
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Interactions of Glibenclamide / Glyburide

Interactions with other medicines

  • Medicines used to treat depression (like Monoamine Oxidase Inhibitors [MAOIs])
  • Medicines used to reduce cholesterol (like Clofibrate)
  • Medicines used to treat bacterial infections (like Chloramphenicol, Sulphonamides, and Tetracyclines)
  • Medicines used to treat fungal infections (e.g., Miconazole)
  • Medicines used to treat gout (like Sulfinpyrazone)
  • Oral contraceptives
  • Medicines used to reduce pain and inflammation (like Aspirin, other Non-Steroidal Anti-Inflammatory Drugs)
  • Blood thinner (like Warfarin)
  • Medicines used to treat an underactive thyroid gland

Interactions with food items

It is advised to follow a strict diabetic diet and exercise regimen to improve the overall control of the disease further. Avoid alcohol.

Dosage of Glibenclamide / Glyburide


Inform your doctor immediately in case of overdose. Your blood sugar levels have likely gone too low in the event of an overdose. Quickly consume some sugar or sugar-containing drinks and report to th...
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Missed a Dose

If you missed any dose of medicine, take it as soon as you remember. If it's time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dos...
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Content Details


Dr. Nikita Toshi

BDS (Bachelor of Dental Surgery)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What should I discuss with the health care provider before taking medicine?

A: Tell your doctor if you have or have ever had G6PD deficiency (an inherited condition causing premature destruction of red blood cells) or having sulfa allergy and the relevant medical and surgical history, your past and ongoing medicines, etc.

Q: What should I know regarding the storage of medicine?

A: Store it in a cool, dry place. Keep away from children.

Q: When and how to consume the medicine?

A: Take Glibenclamide orally 10-15 minutes before food unless your doctor tells you otherwise. Dosage and duration of treatment to be taken as advised by the doctor.

Q: Can I take this medicine if I have an allergy to sulfa medicines?

A: Glibenclamide belongs to the Sulfonylurea group, which contains sulfa content; hence, this medicine should not be taken by patients with sulfa allergy.
Last Updated on: 24 Dec 2020 | 01:48 PM (IST)
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