Glibenclamide / Glyburide

When should one not use Glibenclamide / Glyburide

• If you are allergic to Glibenclamide / Glyburide or any other ingredients of this medicine.
• If you have severe problems with your liver or kidney.
• If you have type 1 diabetes.
• If you are in a diabetic coma.
• If you are suffering from diabetic ketoacidosis (symptoms include fatigue, nausea, frequent urination and muscle stiffness).
• If you are pregnant, think you may be or are breastfeeding.
• If you are taking a medicine called bosentan to treat your high blood pressure.

Common side effects of this drug are:

• Headache
• Dizziness
• Nausea
• Vomiting
• Low blood sugar level

Other General Warnings

• You have problems with your heart, liver or kidneys
• You have problems with your adrenal or pituitary glands
• You are scheduled to have a surgery or operation
• You develop fever or infection
• You consume alcohol on regular basis
• You have a blood enzyme deficiency (glucose-6-phosphate dehydrogenase deficiency).
• You are above 60 years old
• You should let the doctor, or the laboratory person know that you are using this medicine while going for a lab test, as this medicine may interfere with the lab tests.
• Do not stop taking this medicine unless told to do so by your doctor.
• Glibenclamide / Glyburide is not recommended for use in patients less than 18 years old.

How Does It Work?

Interactions with other medicines

• Some medicines can affect the way Glibenclamide / Glyburide works or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
• Tell your doctor about all the medicines, supplements or herbals you are currently taking or might take to avoid any possible interactions.
• Especially, if you are taking medicines to treat your blood pressure, diabetes, heart problems, high cholesterol levels, mental health problems, cancer, thyroid problems, gout, tuberculosis, fits, infections, glaucoma, stomach ulcers, allergies, blood thinner medicines, prostate problems, pain and inflammation.
• Other medicines like pentoxifylline, oestrogen, progestogen, laxatives should be used with caution along with Glibenclamide / Glyburide.
• You should let the doctor or the laboratory person know that you are using Glibenclamide / Glyburide while going for a lab test, as this medicine may interfere with the lab tests.

Interactions with food items

Overdose

• An overdose of Glibenclamide / Glyburide may lead to low blood sugar levels (symptoms include nausea, vomiting, restlessness, shakiness, visual disturbances, sleepiness) and coma.
• Immediately consume some sugar or sugar-containing drink.
• Do not give the person any food or drink if the person is unconscious.
• Seek medical attention in case you have consumed too much of this medicine.

Missed a Dose