Home Molecules Glibenclamide / Glyburide

Glibenclamide / Glyburide

Molecule Description

Glibenclamide is an antidiabetic medicine that belongs to the Sulfonylurea grou

p. It reduces high blood sugar level in the body. It mainly prevents postprandial blood sugar (blood sugar measured 2 hours after food). This medicine is given in Type 2 diabetes mellitus.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Glibenclamide / Glyburide

Glibenclamide is used as an anti-diabetic medicine for Type 2 diabetes in adults.

Contraindications of Glibenclamide / Glyburide

When should one not use Glibenclamide / Glyburide

If you have any allergic reactions to Glibenclamide
If you are suffering from Type 1 diabetes or ketoacidosis (caused by excessively high blood sugars in people with Type 1 diabetes)
If you have reduced consciousness or you are going to have any surgery
If you are suffering from severe kidney disease or any severe infections

Side effects of Glibenclamide / Glyburide

Common side effects of this drug are:

Low blood glucose levels causing fainting, sweating, and giddiness
Headache
Nausea
Vomiting
Diarrhea
Abdominal pain
Increase in appetite
Allergic skin reactions
Anemia
Weight gain
Elevation of liver enzyme levels
Water retention
Jaundice is rare

Precautions and Warnings of Glibenclamide / Glyburide

Pregnancy

Can I take Glibenclamide / Glyburide during pregnancy?

Usage of this medicine in pregnant women is not recommended unless needed. Please consult with your doctor.

Breast Feeding

Can I take Glibenclamide / Glyburide while breastfeeding?

Use this medicine while breastfeeding only when needed. Please consult with your doctor.

Driving

Can I drive if I have consumed Glibenclamide / Glyburide?

If your blood sugar is not under control, then this may affect your vision or concentration level. Do not drive until you feel well.

Alcohol

Can I consume alcohol with Glibenclamide / Glyburide?

Too much intake of alcohol has to be avoided when you are taking this medicine for controlling blood sugar levels.

Other General Warnings

Talk to your doctor if

Suffer from severe kidney disease or liver problems
Suffering from ketoacidosis (caused by excessively high blood sugars in people with diabetes)
Suffering from a severe infection
Suffering from stress or from any condition likely to make controlling your blood sugar difficult
If you have undergone any surgeries
If you have porphyria (a disease of blood proteins affecting the skin, gut and nervous system)
If you have intolerance to some sugars

Mode of Action of Glibenclamide / Glyburide

How Does It Work?

In diabetes mellitus, either there is a deficiency in insulin secretion from the pancreas, or there is resistance to its action at the cellular level, sometimes even both. Glibenclamide increases insu...

Interactions of Glibenclamide / Glyburide

Interactions with other medicines

Medicines used to treat depression (like Monoamine Oxidase Inhibitors [MAOIs])
Medicines used to reduce cholesterol (like Clofibrate)
Medicines used to treat bacterial infections (like Chloramphenicol, Sulphonamides, and Tetracyclines)
Medicines used to treat fungal infections (e.g., Miconazole)
Medicines used to treat gout (like Sulfinpyrazone)
Oral contraceptives
Medicines used to reduce pain and inflammation (like Aspirin, other Non-Steroidal Anti-Inflammatory Drugs)
Blood thinner (like Warfarin)
Medicines used to treat an underactive thyroid gland

Interactions with food items

It is advised to follow a strict diabetic diet and exercise regimen to improve the overall control of the disease further. Avoid alcohol.

Dosage of Glibenclamide / Glyburide

Overdose

Inform your doctor immediately in case of overdose. Your blood sugar levels have likely gone too low in the event of an overdose. Quickly consume some sugar or sugar-containing drinks and report to th...

Missed a Dose

If you missed any dose of medicine, take it as soon as you remember. If it's time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dos...

Content Details

WRITTEN BY

Dr. Nikita Toshi

BDS (Bachelor of Dental Surgery)

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: What should I discuss with the health care provider before taking medicine?

A: Tell your doctor if you have or have ever had G6PD deficiency (an inherited condition causing premature destruction of red blood cells) or having sulfa allergy and the relevant medical and surgical history, your past and ongoing medicines, etc.

Q: What should I know regarding the storage of medicine?

A: Store it in a cool, dry place. Keep away from children.

Q: When and how to consume the medicine?

A: Take Glibenclamide orally 10-15 minutes before food unless your doctor tells you otherwise. Dosage and duration of treatment to be taken as advised by the doctor.

Q: Can I take this medicine if I have an allergy to sulfa medicines?

A: Glibenclamide belongs to the Sulfonylurea group, which contains sulfa content; hence, this medicine should not be taken by patients with sulfa allergy.

References

NPRA. Dyanil tablet. [Accessed on 14.nov.2019] (online):

Last Updated on: 24 Dec 2020 | 01:48 PM (IST)

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परिचय: “बिना मशरूम के खाना बिना बारिश के दिन जैसा होता है”। मशरूम या अगरिकस बिस्पोरस न तो सब्ज़ी है और न ही फल, बल्कि यह खाई जाने वाली एक फंगस है। बाजार में इसकी अलग-अलग किस्में (ताजा व सूखा) उपलब्ध हैं; जिसमे ओएस्टर , पोर्सिनी और बटन सबसे आम किस्में हैं। आमतौर पर, मशरूम

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परिचय वानस्पतिक नाम एम्ब्लिका ऑफिसिनैलिस आमतौर पर आंवला को इंडियन गूजबेरी (भारतीय करौंदा) कहा जाता है। इन पेड़ों की बेरी को इनके औषधीय गुणों के कारण औषधीय फार्मूलेशन में प्रयुक्त किया जाता है। आंवला के पेड़ पर छोटी बेरीज़ होती हैं जो गोल और पीले-हरे रंग की होती है। इसके कई स्वास्थ्य फ़ायदों के कारण

केला (Banana in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: “एक दिन में एक केला (बनाना) खाने से मेरा एंडोर्फिन लेवल बना रहता है।” बनाना (मूसा प्रजाति) या केला एक लंबा, पीला फल है जो वास्तव में एक बेरी है। यह मुसासी (मुसासेई) परिवार से संबंधित हैं और इसमें मूसा एक्यूमिनाटा, मूसा बालबिसियाना आदि किस्में शामिल हैं। यह दक्षिणी एशिया के उष्णकटिबंधीय क्षेत्रों (ट्रॉपिकल

सौंफ (Fennel Seed in Hindi) : उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: सौंफ (फेनल सीड) का वैज्ञानिक नाम फीनीकुलम वल्गारे है और यह एपोकिनेसी परिवार से संबंधित एक सुगंधित पौधा है।1 सौंफ (फेनल सीड) की एक अलग आकृति, आकार और रंग होता है; यह लंबी, पतली होती है और हल्के हरे या भूरे रंग की होती है। सौंफ (फेनल सीड) का पौधा इसके बीजों, पत्तियों और

ड्रैगन फ्रूट (Dragonfruit in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

ड्रैगन फ्रूट कैक्टस प्रजाति का फल होता है जिसके स्वास्थ्य से जुड़े कई लाभ होते हैं जैसे कि रक्त शर्करा (ब्लड शुगर) के जोखिम को कम करना, पाचन (डाइजेशन) में मदद करना आदि। यह एक ड्रैगन की तरह दिखता है और इस वजह से इसका यह नाम पड़ा। अब आप सोच रहे होंगे कि इस

तेजपत्ता (Bay Leaves in Hindi)– उपयोग, फायदे और न्यूट्रिशनल वैल्यू

परिचय तेजपत्ता सिनामोमम तमाला नामक पौधे की सूखी पत्तियां होती हैं। यह सिनामोमम वंश के लौरेसी परिवार का पौधा होता है जिसकी 270 प्रजातियां हैं और प्रमाणिक रूप से ये सभी एशिया और ऑस्ट्रेलिया में पाई जाती हैं। तेजपत्ता को भारतीय बे-लीफ़ भी कहा जाता है जो छोटे सदाबहार या बारहमासी वृक्ष पर होते हैं

नाशपाती (Pear in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू आदि!

परिचय: नाशपाती का वैज्ञानिक नाम पायरस कमिनिस एल है। यह रोज़ेसी फ़ैमिली से संबंधित है। नाशपाती को सेब के बाद सबसे ज्यादा पौष्टिक फल माना जाता है। यह विटामिन आहार फाइबर, एमिनो एसिड, एवं क्वेरसेटिन का बढ़िया स्रोत होता है। नाशपाती अपने मिठास, सुगंध, कुरकुरेपन और ख़ास खुशबू के लिए जाना जाता है। मूल रूप

सीए 125 टेस्ट (महिलाओं के लिए) (CA 125 Test (For Women) in Hindi): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: सीए 125 टेस्ट का इस्तेमाल शरीर में सीए 125 प्रोटीन के स्तर का पता लगाने के लिए किया जाता है, जो कैंसर का पता लगाने में मददगार साबित हो सकता है। नमूना प्रकार खून उपवास \ खाली पेट रहना जरूरी: नहीं उपनाम: कैंसर एंटीजन 125 टेस्ट, सीए-125 ट्यूमर मार्कर, सीए 125 ब्लड टेस्ट। सीए

सीरम इलेक्ट्रोलाइट्स (Serum Electrolytes): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: एक सीरम इलेक्ट्रोलाइट परीक्षण आपके खून में मौजूद इलेक्ट्रोलाइट्स के स्तर को मापने की एक विधि है। इससे किडनी या दिल की समस्याओं जैसी कई बीमारियों का निदान करने में मदद मिल सकती है। आपको यह परीक्षण कितनी बार लेना चाहिए? कोई विशिष्ट आवृत्ति नहीं है। डॉक्टर आमतौर पर सीरम इलेक्ट्रोलाइट परीक्षण को मेटाबोलिक

हींग (Asafoetida in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू और अन्य बातें!

परिचय दुनिया के बहुत से हिस्सों में, हींग (ऐसाफ़ेटिडा) को खाने का स्वाद बढ़ाने वाले तत्व के रूप में और विभिन्न प्रकार की बीमारियों का पारंपरिक रूप से उपचार करने के लिए किया जाता है। हींग (फ़ेरुला ऐसाफ़ेटिडा), एक ओलिओ-गम-रेज़िन है जो अंबेलीफेरा फ़ैमिली के फ़ेरुला पौधों के तनों में बनती है। फ़ेरुला के पौधे

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