Estradiol

• Estradiol is used to treat oestrogen deficiency in peri and postmenopausal women as a hormone replacement therapy (HRT).
• It is also used to reduce the risk of osteoporosis and fractures.

When should one not use Estradiol

• If you are allergic to estradiol.
• If you had a history of or have breast cancer.
• If you have undiagnosed abnormal vaginal bleeding.
• If you had a history of or are suspected to have oestrogen-dependent tumours such as endometrial cancer.
• If you have untreated thickening of the endometrial lining.
• If you have or had a severe liver or renal problem.
• If you had or have any blood clotting disorder of veins such as venous thromboembolism.
• If you have any heart-related conditions such as chest pain due to blockage in arteries (myocardial infarction, angina).
• If you have-blood related disorders such as porphyria, protein C, protein S deficiency.

Common side effects of this drug are:

• Headache
• Migraine
• Altered mood
• Increased or decreased weight
• Increased appetite
• Visual disturbance
• Dizziness
• Fatigue
• Skin rash
• Palpitations

Other General Warnings

• You experience or have thickening of the endometrium.
• You have liver, kidney, thyroid or heart-related problems.
• You have bleeding or clotting disorder.
• You have high blood pressure, diabetes, asthma, fits, thickening of ear tissue.
• You have a risk of cancer such as breast or the endometrium.
• You have allergic conditions such as systemic lupus erythematosus (SLE).
• You have a severe headache or migraine.
• You had or have decreased blood supply to the brain (stroke).
• You experience fluid retention in the body.
• You have a high lipid level in the body.

How Does It Work?

Interactions with other medicines

• Some medicines may alter the effect of Estradiol or this medicine may alter the effect of other medicines.
• Concomitant use of Estradiol and anti-fits medicines like phenytoin, primidone, anti-infective medicines like rifampicin, rifabutin and herbal products like St. John's wort can decrease the effect of Estradiol.
• Anti-HIV medicines like saquinavir, indinavir, etc when used with Estradiol can interfere with the effect of this medicine.
• Anti-fungal medicines like fluconazole, itraconazole may increase the effect of Estradiol and may increase the risk of side effects.
• Tell your doctor about all the medicines, supplements or herbals you are currently taking or might take to avoid any possible interaction.

Overdose

Missed a Dose