Estradiol
Description
Estradiol is a semi-synthetic variety of the female hormone oestrogen used to t
reat oestrogen deficiency and other female hormone-related disorders in peri and postmenopausal women. It is also used to reduce the risk of osteoporosis in postmenopausal women who are prone to fractures. This medicine replenishes the decreased level of oestrogen in the body. Take this as advised by your doctor for the prescribed duration. Before using this medicine, inform the doctor about your detailed medical history.
Uses
- Estradiol is used to treat oestrogen deficiency in peri and postmenopausal women as a hormone replacement therapy (HRT).
- It is also used to reduce the risk of osteoporosis and fractures.
Contraindications
When should one not use Estradiol
- If you are allergic to estradiol.
- If you had a history of or have breast cancer.
- If you have undiagnosed abnormal vaginal bleeding.
- If you had a history of or are suspected to have oestrogen-dependent tumours such as endometrial cancer.
- If you have untreated thickening of the endometrial lining.
- If you have or had a severe liver or renal problem.
- If you had or have any blood clotting disorder of veins such as venous thromboembolism.
- If you have any heart-related conditions such as chest pain due to blockage in arteries (myocardial infarction, angina).
- If you have-blood related disorders such as porphyria, protein C, protein S deficiency.
Side effects
Common side effects of this drug are:
- Headache
- Migraine
- Altered mood
- Increased or decreased weight
- Increased appetite
- Visual disturbance
- Dizziness
- Fatigue
- Skin rash
- Palpitations
Precautions and Warnings
Pregnancy
Q:
Can I take Estradiol during pregnancy?
A:
Estradiol should not be used during pregnancy. When pregnancy is detected, this medicine should be discontinued immediately. Inform your doctor if you are pregnant or think you may be or are planning for a baby before starting this medicine.
Breast Feeding
Q:
Can I take Estradiol while breastfeeding?
A:
Estradiol should not be used while breastfeeding. Inform your doctor if you are a breastfeeding mother.
Driving
Q:
Can I drive if I have consumed Estradiol?
A:
If you experience dizziness, headache after taking Estradiol, then avoid driving or operating machines.
Alcohol
Q:
Can I consume alcohol with Estradiol?
A:
Do not consume alcohol with Estradiol as it may alter the effectiveness of this medicine. Talk to your doctor if you consume it often.
Other General Warnings
Talk to your doctor if
- You experience or have thickening of the endometrium.
- You have liver, kidney, thyroid or heart-related problems.
- You have bleeding or clotting disorder.
- You have high blood pressure, diabetes, asthma, fits, thickening of ear tissue.
- You have a risk of cancer such as breast or the endometrium.
- You have allergic conditions such as systemic lupus erythematosus (SLE).
- You have a severe headache or migraine.
- You had or have decreased blood supply to the brain (stroke).
- You experience fluid retention in the body.
- You have a high lipid level in the body.
Mode of Action
How Does It Work?
Estradiol is a semi-synthetic version of the hormone estrogen present in the body of females. Its action is identical to biological estrogen. It binds to the estrogen receptors and shows a beneficial effect on bone density and inhibit bone restoration associated with osteoporosis in menopausal women....
Interactions
Interactions with other medicines
- Some medicines may alter the effect of Estradiol or this medicine may alter the effect of other medicines.
- Concomitant use of Estradiol and anti-fits medicines like phenytoin, primidone, anti-infective medicines like rifampicin, rifabutin and herbal products like St. John's wort can decrease the effect of Estradiol....
- Anti-HIV medicines like saquinavir, indinavir, etc when used with Estradiol can interfere with the effect of this medicine.
- Anti-fungal medicines like fluconazole, itraconazole may increase the effect of Estradiol and may increase the risk of side effects.
- Tell your doctor about all the medicines, supplements or herbals you are currently taking or might take to avoid any possible interaction.
Dosage
Overdose
Symptoms of overdose are nausea and vomiting. If you experience any of the symptoms or think you have taken too much of Estradiol, contact your doctor immediately or visit the nearest hospital
Missed a Dose
Missing a dose of Estradiol may reduce the effectiveness of the treatment. If you missed any dose of medicine take it as soon as you remember. If it's time for your next dose, then skip the missed dose and continue with your regular dose schedule. Do not take a double dose of medicine to compensate for the missed one....
Content Details
WRITTEN BY
Dr. Arpit Verma
MBBS, MD, CCEBDM Diabetology
REVIEWED BY
Dr. Ritu Budania
MBBS, MD (Pharmacology)
Frequently Asked Questions (FAQs)
Q: Can I stop taking Estradiol on my own?
A: No, you should never stop taking Estradiol until advised by the doctor, even if you are feeling good. If you stop taking this medicine, it may lead to treatment failure.
Q: What is Estradiol used for?
A: Estradiol is used to treat oestrogen deficiency in pre and postmenopausal women as a hormone replacement therapy (HRT). It is also used to reduce the risk of osteoporosis and fractures.
Q: How does Estradiol work?
A: Estradiol contains estradiol as its active component which is a semi-synthetic version of the hormone estrogen present in the body of females. Its action is identical to biological estrogen. It binds to the estrogen receptors and shows a beneficial effect on bone density and inhibit bone restoration associated with osteoporosis in menopausal women.
Q: What are the side effects of Estradiol?
A: Headache, migraine, altered mood, increased or decreased weight, increased appetite, visual disturbance are a few side effects of Estradiol. However, these symptoms are usually mild and resolve on their own. Also, it is not important that everyone experience the same.
References
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Disclaimer
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.
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