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Erlotinib

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Molecule Summary

Uses
Non-small cell lung cancer and pancreatic cancer
Therapy
Anti-Neoplastic
Side Effects
Rash, diarrhoea, stomach pain, tiredness, headache
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Molecule Description

Erlotinib is an anticancer medicine that is used to treat non-small cell lung cancer and pancreatic cancer. It belongs to the group of medicines known as kinase inhibitors. It works by inhibiting the activity of a protein called epidermal growth factor receptor (EGFR) which is responsible for the growth and spread of cancer cells.

Uses

  • Non-small cell lung cancer
  • Pancreatic cancer

Contraindications

When should one not use Erlotinib

  • If you are allergic to erlotinib or any of the ingredients of this medicine.

Side effects

Common side effects of this drug are:

  • Rash
  • Diarrhoea
  • Stomach pain
  • Tiredness
  • Headache
  • Loss of appetite or decreased weight
  • Breathing difficulty
  • Nausea, vomiting

Precautions and Warnings

Pregnancy

Pregnancy

Erlotinib is not recommended for use during pregnancy. So it is advised to use proper contraceptive methods while taking this medicine and for at least 2 weeks after taking the last dose of it, to avoid pregnancy.

Breast Feeding

Breast Feeding

Breastfeeding is not recommended during treatment with Erlotinib and for at least 2 weeks after taking the last dose of this medicine.

Driving

Driving

It is unlikely that this medicine will affect your ability to drive. However, do not drive until you know how Erlotinib affects you.

Alcohol

Alcohol

There is no known interaction between alcohol and Erlotinib. However, it is important to consult your physician if you drink too often.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have a history of eye problems, or use contact lenses, swelling or ulcer in the front part of the eye.
  • You are already taking any other medicines for underlying conditions.
  • You experience sudden breathing difficulty along with cough and fever, severe stomach ache, skin peeling or blistering etc. The doctor might discontinue the treatment with Erlotinib.
  • You experience diarrhoea. the doctor might prescribe you some anti-diarrhoeal medicines.
  • You develop worsening eye conditions, increased eye-watering, blurred vision, redness or pain in the eye etc. You may need urgent treatment.
  • You are already taking cholesterol-lowering medicines and experience muscle pain or cramps. The doctor might stop the treatment immediately.

Mode of Action

How Does It Work?

Erlotinib acts by targeting the proteins EGFR (epidermal growth factor) in cancer cells and stops the cancer cells from growing. In this way, it prevents the spread of cancerous cells.

Interactions

Interactions with other medicines

  • Certain medicines can interfere with the action of Erlotinib if taken at the same time. Always inform your doctor about all the medicine you are taking, which includes all prescribed or non-prescribed herbal medicines, dietary supplements as well as other treatments if you are taking it for any disorder.
  • In particular, if you are taking antifungal medicine like ketoconazole, antibiotic medicine like clarithromycin, anti-tuberculosis medicine like rifampicin, anti-epileptic medicines, medicines for brain-related disorders etc.
  • If you are taking anticoagulant medicines (like warfarin) along with Erlotinib, it might increase the risk of bleeding.
  • Concomitant use of Erlotinib and cholesterol-lowering medicine (statins) can increase the risk of muscle problems due to statins and may also lead to kidney damage.
  • If you have any kind of immunization or vaccination scheduled.

Interactions with food items

Erlotinib should be taken on an empty stomach, at least 1 hour before or 2 hours after eating.

Dosage

Overdose

Overdose of Erlotinib may cause increased side effects. In case of an overdose, contact your doctor or reach out to your nearest hospital as soon as possible. Try to carry the pack of the medicine to make overdose assessment easier for doctor/hospital staff.

Missed a Dose

  • It would be best if you don't miss a dose of anti-cancer medicine as it may lead to treatment failure.
  • If you have missed taking any dose of Erlotinib, take it as soon as you remember.
  • If it's already the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
  • Never take a double dose of medicine to compensate for the missed one.

Frequently Asked Questions (FAQs)

No, Erlotinib is not recommended for the children. Do not give any medicine to children unless told by the doctor.

No, pregnant women should not take Erlotinib. So it is advised to use proper contraceptive methods while taking this medicine and for at least 2 weeks after taking the last dose of it, to avoid pregnancy.

Erlotinib is an anti-cancer medication that works by preventing the activity of a protein called epidermal growth factor receptor (EGFR). As a result, it restricts further growth of the cancer cells.

No, Erlotinib should be taken on an empty stomach, 1 hour before or 2 hours after eating as advised by the doctor.

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