Duloxetine+Pregabalin

Uses	Neuropathic pain and Widespread Musculoskeletal pain (Fibromyalgia).
Therapy	Drugs For Peripheral Neuropathy
Side Effects	Headache, Dizziness, Drowsiness, Difficulty in sleeping, Fatigue, Nausea, Diarrhoea, Dry mouth, Blurred vision, Loss of appetite, Suicidal thoughts.

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Molecule Description

Duloxetine+Pregabalin is a combination medicine used to treat pain and tenderness throughout the body. It is also used for the treatment of nerve pain in the extremities of the body caused by nerve damage. It contains two active ingredients, namely Pregabalin and Duloxetine. This medicine increases serotonin and norepinephrine levels in the body's nervous system. It should be taken as directed by the doctor, in the prescribed doses and duration. Before using Duloxetine+Pregabalin, please inform your doctor if you are pregnant, planning a pregnancy, or breastfeeding, as well as sharing your comprehensive medical history. If side effects trouble you or persist, or if you notice any mood changes or suicidal thoughts, consult your doctor.

Uses

Duloxetine+Pregabalin is used for the management of neuropathic pain and widespread musculoskeletal pain (fibromyalgia).

Contraindications

When should one not use Duloxetine+Pregabalin

If you are allergic to pregabalin or duloxetine, or any other ingredients of this medicine.
If you are taking or have recently taken MAO inhibitor antidepressants, it can cause severe adverse effects.
If you have narrow-angle glaucoma, an eye condition associated with increased fluid pressure inside the eye, which this medicine may worsen.
If you have severe skin conditions.
If you have uncontrolled hypertension.
If you have severe renal impairment.

Side effects

Common side effects of this drug are:

Headache
Dizziness
Drowsiness
Difficulty in sleeping
Fatigue
Nausea
Diarrhoea
Dry mouth
Blurred vision
Loss of appetite
Suicidal thoughts

Precautions and Warnings

Pregnancy

There is limited safety information available about the use of this medicine during pregnancy. Your doctor will carefully consider the benefits and risks before prescribing it to you. Please talk to your doctor first.

Breast Feeding

Duloxetine+Pregabalin passes into breastmilk, but its effect on the breastfed baby is unknown. Your doctor will decide whether to discontinue breastfeeding or to discontinue the treatment with Duloxetine+Pregabalin depending upon the benefits of the medicine for a nursing mother.

Driving

No, it is not safe to drive after taking Duloxetine+Pregabalin. It causes side effects like sleepiness, drowsiness, and double or blurred vision. It is also not safe to operate heavy machinery after taking this medication.

Alcohol

Duloxetine+Pregabalin increases the effects of alcohol. It causes nausea, vomiting, sleepiness, dizziness, and blurred vision. It is not recommended to take this medicine with alcohol.

Other General Warnings

Talk to your doctor if

You have a heart condition, diabetes, or kidney function issues.
You are an elderly patient over the age of 65, as the risk of side effects is high.
You have fluctuating blood pressure. If you are experiencing any mood changes or self-harming thoughts, seek medical help immediately.
You have a history of seizures.
You may experience a slight drop in blood glucose levels.
Do not stop this medication abruptly; your doctor will decrease the dose gradually.
You are pregnant, planning a pregnancy or breastfeeding.
You have a bleeding disorder.
You have had self-harming or suicidal thoughts.
You are using any other antidepressant.
Duloxetine+Pregabalin is not recommended for patients under 18 years of age.

Mode of Action

How Does It Work?

Duloxetine+Pregabalin works by the combined action of duloxetine and pregabalin. Duloxetine increases the levels of certain feel-good chemical messengers (serotonin and norepinephrine) in the brain. Pregabalin reduces the release of certain pain-signalling chemical messengers from overactive nerve cells by acting on calcium channels.

Interactions

Interactions with other medicines

Sometimes Duloxetine+Pregabalin may affect the way other medicines work and other medicines may affect how Duloxetine+Pregabalin works if taken at the same time.
Tell your doctor about all the medicines, supplements or herbals you are currently taking or might take to avoid any possible interactions.
Especially, if you are taking medicines for brain-related disorders or calmness of the brain, as it can cause sleepiness or dizziness.
Medicines like oxycodone used for serious painful conditions if taken along can lead to a loss of memory and the ability to perform normal physical movements.
If you are on blood thinners like aspirin, warfarin, etc., taking them with Duloxetine+Pregabalin can increase the risk of abnormal bleeding.
Do not mix antibiotics like ciprofloxacin with these medicines; it increases the levels of Duloxetine in blood and can cause serious effects.
Inform your doctor if you use other medicines like sertraline, lithium and dextromethorphan. They can cause severe side effects.

Interactions with food items

Some brain-stimulating things like coffee, energy drinks, etc., interfere with the effects of this medicine.
Avoid grapefruit and its juice, as it can interfere with this medicine.

Dosage

Overdose

Symptoms of an overdose are similar to common side effects like sleepiness, restlessness, irritation, nausea, vomiting, increased heart rate, seizures, fainting, low blood pressure and coma. If you think you have taken too much of Duloxetine+Pregabalin contact your doctor immediately or visit the nearest hospital.

Missed a Dose

If you have missed a dose of Duloxetine+Pregabalin, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and follow your normal dosing schedule. Do not take two doses together or within a few hours of each other to make up for the missed one, as it can cause an overdose. Talk to your doctor if you have any confusion about the dosage.

Frequently Asked Questions (FAQs)

No, you should not stop taking Duloxetine+Pregabalin on your own even if you feel better. Your doctor will decide when to stop this or reduce the dose. Also, your doctor will gradually decrease the dose before stopping it.

It is recommended that you take the medicine at the same time each day. If you feel that you may be drowsy throughout the day because of it, then you can take it in the evening. Take it with a glass of water as directed by your doctor.

Duloxetine+Pregabalin is not recommended in patients below 18 years of age.