Disodium Hydrogen Citrate
Description
Disodium Hydrogen Citrate is a medicine used to treat kidney stones, gout, urin
ary tract infections, and other conditions caused by high uric acid levels. It works by making your urine less acidic, which helps dissolve uric acid and other substances that can form stones or crystals in the urinary tract. This makes it easier for your body to flush these substances out through urine, preventing new stones from forming and easing symptoms such as burning or pain during urination. To get the best results, it should be taken exactly as prescribed by your doctor, usually after meals, and it is important to drink plenty of water while on this medicine. Patients with kidney, heart, or lung conditions, or those on a low-sodium or low-potassium diet, should consult their doctor before using it.
Uses
- Disodium Hydrogen Citrate is used to treat gout (increased uric acid levels) and kidney stones.
- It is also used to treat urinary tract infections and metabolic disorders associated with kidney disease.
Contraindications
When should one not use Disodium Hydrogen Citrate
- If you are allergic to Disodium Hydrogen Citrate.
- If you have kidney diseases.
- If you have high sodium or potassium levels.
- If you have high blood pressure, irregular heartbeats, or heart failure.
- If you have low calcium levels.
- If you have lung diseases.
- If you have diabetes.
- If you have Addison's disease (an adrenal gland disorder).
Side effects
Common side effects of this drug are:
- Stomach pain
- Weakness
- Nausea
- Vomiting
- Diarrhoea
Precautions and Warnings
Pregnancy
Q:
Can I take Disodium Hydrogen Citrate during pregnancy?
A:
There is limited information available on the use of Disodium Hydrogen Citrate during pregnancy. It is recommended not to use it during pregnancy, unless advised by a doctor.
Breast Feeding
Q:
Can I take Disodium Hydrogen Citrate while breastfeeding?
A:
Disodium Hydrogen Citrate may cause some adverse effects on the baby. Hence, this medicine is not advised during breastfeeding.
Driving
Q:
Can I drive if I have consumed Disodium Hydrogen Citrate?
A:
Disodium Hydrogen Citrate does not affect your driving ability. However, if you experience any discomfort or side effects, then avoid driving.
Alcohol
Q:
Can I consume alcohol with Disodium Hydrogen Citrate?
A:
This medicine can cause dehydration, and the consumption of alcohol can increase the risk of dehydration. Hence, it is recommended to avoid consuming alcohol while taking Disodium Hydrogen Citrate.
Other General Warnings
Talk to your doctor if
- You are diabetic.
- You have a kidney disease.
- You are suffering from chronic diarrhoea (such as ulcerative colitis and Crohn's disease).
- Do not alter the dose of Disodium Hydrogen Citrate by yourself.
- Take this medicine with food for better absorption and to help prevent stomach-related side effects.
Mode of Action
How Does It Work?
Disodium hydrogen citrate is metabolised to bicarbonates. These bicarbonate ions are excreted in the urine by increasing the urinary pH. This increase in pH makes the urine less acidic. This increase in urinary pH helps remove excess uric acid....
Interactions
Interactions with other medicines
- May interact with other medicines, over-the-counter products, and herbal preparations, potentially altering their effects.
- Antacids containing aluminium and magnesium should be taken at least two hours after this medicine.
- May interact with Aspirin.
- Other medicines that can interact include Lithium, Quinidine, and Salicylates.
Dosage
Overdose
- If you think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital.
Missed a Dose
If you missed a dose of the medicine, take it as soon as you remember. If it is time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one....
Content Details
WRITTEN BY
Ravindra Ghongade
B. Pharm
REVIEWED BY
Dr. Nikita Toshi
BDS (Bachelor of Dental Surgery), WHO FIDES member
Frequently Asked Questions (FAQs)
Q: What is Disodium Hydrogen Citrate used for?
A: Disodium Hydrogen Citrate is used to treat kidney stones, gout, urinary tract infections, and other conditions caused by high uric acid levels. It helps make urine less acidic, which dissolves uric acid and other substances that can form stones or crystals.
Q: How does Disodium Hydrogen Citrate work?
- It makes your urine more alkaline, helping dissolve uric acid and other crystals so they can be flushed out of the body, preventing new stone formation and easing urinary discomfort.
Q: Can I stop Disodium Hydrogen Citrate suddenly?
- No, do not stop the medicine without your doctor’s advice, as this may worsen your condition or lead to recurrence of kidney stones.
References
View All
- Cytra-K (potassium citrate/citric acid) dosing, indications, interactions, adverse effects, and more [Internet]. Reference.medscape.com. 2025 [cited 8 Dec 2025].
- CDSCO [Internet]. Cdscoonline.gov.in. 2025 [cited 8 Dec 2025].
- National Center for Biotechnology Information (2025). PubChem Compound Summary for CID 8950, Disodium Hydrogen Citrate. [cited 8 Dec 2025].
- Hong J, Bhaskar S, Golab JT, Kaduk JA. Structures of disodium hydrogen citrate monohydrate, Na₂HC₆H₅O₇(H₂O), and diammonium sodium citrate, (NH₄)₂NaC₆H₅O₇, from powder diffraction data. Acta Crystallogr Sect E Crystallogr Commun [Internet]. 2020 [cited 8 Dec 2025].
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Disclaimer
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.
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