Diethylstilbestrol

Uses	Prostate cancer, Postpartum lactation suppression, Postmenopausal breast cancer, Atrophic vaginitis, Gonorrheal vaginitis, Menopausal symptoms
Therapy	Post Menopausal Care
Side Effects	Breast swelling and tenderness, Nausea and weight gain, Abdominal pain and cramps, Loss of appetite, Painful menstruation, Bloating

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Molecule Description

Diethylstilbestrol (DES) is a synthetic form of the female hormone, oestrogen. It is a medicine used in the treatment of prostate cancer in men and also for certain conditions in women, such as menopausal symptoms and postmenopausal breast cancer. Prostate cancer refers to the growth of cancer cells in the prostate gland (semen producing gland). It is one of the most common cancers seen in men. Originally diethylstilbestrol was created to help women boost their natural oestrogen production.

Uses

Treatment of prostate cancer
Treatment of postpartum lactation suppression
Treatment of postmenopausal breast cancer
Treatment of atrophic vaginitis
Treatment of gonorrheal vaginitis
Treatment of menopausal symptoms

Contraindications

When should one not use Diethylstilbestrol

If you have breast cancer
If you are pregnant
If you have a bleeding disorder
If you have an allergy to diethylstilbestrol or any other component of this medicine
If you have lactose intolerance
If you have any liver disease

Side effects

Common side effects of this drug are:

Breast swelling and tenderness
Nausea
Weight gain
Abdominal pain and cramps
Loss of appetite
Painful menstruation
Bloating

Precautions and Warnings

Pregnancy

Diethylstilbestrol is not recommended during pregnancy as studies have shown harmful effects of the medicine on the developing baby. Consult your doctor.

Breast Feeding

You should consult your doctor before taking this medicine if you are breastfeeding. Studies showed undetectable amounts of it in breastmilk, so it is unlikely to cause severe damage in babies. Still, it is essential to proceed with caution.

Driving

Diethylstilbestrol may cause side effects that could affect your ability to drive. The medicine may decrease alertness, and make you feel dizzy and lightheaded. Do not drive if you are experiencing side effects after taking this medicine.

Alcohol

Avoid consuming alcohol with Diethylstilbestrol. It increases the severity of side effects like drowsiness, dizziness, lethargy, liver injury, etc. It also worsens the condition of the disease for which you are using this medicine.

Other General Warnings

Talk to your doctor if

You have a kidney or liver disease for appropriate dose adjustments.
You have heart disease or if your blood arteries are clogged.
You experience side effects that are worsening or bothering you.
You are pregnant, planning to become pregnant or are breastfeeding.
Before starting the treatment, inform your doctor about all the prescription and over-the-counter medicines you are already taking.

Mode of Action

How Does It Work?

Diethylstilbestrol is a nonsteroidal synthetic oestrogen that has similar effects to natural oestrogens produced in the body. It works by interacting with the oestrogen receptors, which are present in the female reproductive tract, hypothalamus (part of the brain), mammary glands (breast tissue) and the pituitary (part of the brain). In the case of prostate cancer, it works by decreasing the production of testosterone.

Interactions

Interactions with other medicines

Tell your doctor and pharmacist about any prescription and non-prescription medications, herbal products, vitamins and nutritional supplements, you are taking or plan to take as there is a chance of drug interaction. Many medicines can interact with Diethylstilbestrol, making it less effective or increasing side effects. This includes:
Medicines like tranexamic acid, sodium tetradecyl sulphate and certain anti-aromatase agents are very dangerous if consumed with Diethylstilbestrol.
Griseofulvin, nevirapine, troleandomycin, chloramphenicol, boceprevir, clobazam, telaprevir, mifepristone, and artemether produce harmful side effects when consumed along with Diethylstilbestrol.

Interactions with food items

You can continue with the usual diet as food doesn't influence the effect of Diethylstilbestrol. Talk to your doctor about any supplements or herbal drinks you are currently taking before using Diethylstilbestrol.

Dosage

Overdose

Diethylstilbestrol overdose can cause symptoms like nausea, vomiting, diarrhoea. If you overdose on Diethylstilbestrol and experience any of these symptoms, immediately seek emergency medical treatment from a nearby hospital.

Missed a Dose

If you miss taking a dose of Diethylstilbestrol, take it as soon as possible. If your next dose is approaching, skip the missing dose and return to your regular schedule. Do not take two doses at the same time to make up for the missed dose.