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Dexamethasone+Chloramphenicol

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Molecule Summary

Uses
Bacterial infections of the eye
Therapy
Occular Or Otic Antibiotic And Steroid
Side Effects
Burning sensation, irritation in the eye, blurred vision
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Molecule Description

Dexamethasone+Chloramphenicol is a combination of anti-inflammatory steroid dexamethasone and an antibiotic chloramphenicol.

Uses

To treat various bacterial infections of the eyes that may lead to symptoms like redness, pain, inflammation and swelling.

Contraindications

When should one not use Dexamethasone+Chloramphenicol

  • If you are allergic to the active ingredients in the eye drops dexamethasone and/or chloramphenicol.
  • If you have a family history or are suffering from various blood-related disorders like aplastic anaemia.
  • If you are suffering from fungal infections.
  • If you are suffering from following eyes-related infective conditions like Pseudomonas and mycobacterial infections, Epithelial Herpes simplex keratitis (dendritic keratitis), vaccinia, varicella-zoster and most other viral infections of the cornea and conjunctiva, Amoebic Keratitis.
  • If you are suffering from injury to the cornea.
  • If you are suffering from a condition of high blood pressure known as glucocorticosteroid induced hypertension.

Side effects

Common side effects of this drug are:

  • Burning and stinging sensation
  • Irritation in the eyes
  • Blurred vision usually mild and may not last for long
  • Eye discharge
  • Increased pressure in eyes
  • Inform your doctor if you experience allergic reactions like shortness of breath, swelling on the face, tongues, lips, itchy rash along with swelling of the skin

Precautions and Warnings

Pregnancy

Pregnancy

There is limited information related to the usage of Dexamethasone+Chloramphenicol during pregnancy. It is highly recommended that you should consult your doctor if you are pregnant or think you may be pregnant or are planning to have a child before starting this medicine.

Breast Feeding

Breast Feeding

Dexamethasone+Chloramphenicol can be used during the phase of breastfeeding as it is intended for external use and there are fewer chances that the active ingredients would enter the breast milk and affect the newborn.

Driving

Driving

Use of Dexamethasone+Chloramphenicol may lead to short term side-effects like blurred vision, eye discharge, irritation and burning which may lead to visual disturbances and hamper your ability to drive. Thus, it is recommended that you should avoid driving immediately after using this medicine.

Alcohol

Alcohol

There is no known interaction between Dexamethasone+Chloramphenicol and alcohol.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You are pregnant or planning for a baby.
  • You are allergic to the active ingredients dexamethasone and/or chloramphenicol.
  • You have fungal infections in the eye.
  • You have a damaged surface of the eye (small holes, ulcers or injury which have not healed properly).
  • You have increased pressure in the eye (glaucoma).
  • You are on medicines that act on the immune system.
  • You are diabetic.
  • You are on topical beta-blockers used to treat increased pressure in the eyes.
  • If you have severe allergic conjunctivitis (redness, swelling, itching and tears in the eye).
  • You have dry eyes.
  • You have a light-sensitive vision.
  • Do not use it if the medicine liquid is cloudy or turbid.
  • Do not wear contact lenses while using the eye drops. You can wear them again 15-20 minutes after instilling the drops.

Mode of Action

How Does It Work?

Dexamethasone+Chloramphenicol is a combination of Dexamethasone and Chloramphenicol. Dexamethasone is a steroid that is an anti-inflammatory and anti-allergic medicine. It prevents the release of chemical substances that cause inflammation. Chloramphenicol is an antibiotic that halts or stops the growth of bacteria (bacteriostatic) by interfering with the essential bacterial cellular processes.

Interactions

Interactions with other medicines

  • Tell your doctor about any other medicine, supplement or OTC products you are taking.
  • If you use another eye drop product concomitantly with Dexamethasone+Chloramphenicol, keep a minimum gap of 15 minutes between the application of two medicines.
  • Inform your doctor if you are on medicines like methotrexate (used for treating cancer), azathioprine (used for treating immune system disorders).
  • Caution should be exercised while using medicines like Timolol, betaxolol, levobunolol (topical beta-blockers used to treat high pressure in eyes) along with Dexamethasone+Chloramphenicol as there may be a risk of the calcium phosphate settling on the surface of the eye.
  • Concomitant use of Dexamethasone+Chloramphenicol along with ritonavir or cobicistat, may increase the amount of dexamethasone in the blood causing undesired effects.

Dosage

Overdose

As Dexamethasone+Chloramphenicol is intended to be used externally, the chance of overdose is less likely. Nevertheless, if you accidentally add more drops and then experience worsening symptoms like increased pain, inflammation, irritation and burning in the eyes or swelling, you are advised to visit your doctor or nearest hospital immediately.

Missed a Dose

If you have missed using Dexamethasone+Chloramphenicol, instil the medicine as soon as you remember if the next installation is more than 4 hours later.

Frequently Asked Questions (FAQs)

Dexamethasone+Chloramphenicol can be used at any time of the day in the dose as recommended. It is recommended that you instil the eye drops same time each day until you are recommended to.

Do not wear contact lenses while you are instilling eye drops. You can wear the contact lenses back 15-20 minutes after instilling the eye drops. Nevertheless, it is recommended to wear spectacles if available.

No, these eye drops are not recommended in children below 2 years of age. In case of eye infection in children, you should consult your child's doctor for an apt medicine and not self medicate.

Burning, irritation, blurred vision, discharge from the eye are common side-effects observed on using Dexamethasone+Chloramphenicol which usually do not last for long. In case you feel an unbearable burning sensation for a long duration of time you should wash your eyes with plenty of water and visit your nearest doctor.

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