Desvenlafaxine

Uses	Depression
Therapy	Anti-Depressant
Side Effects	Nausea, Fatigue, Dryness in mouth, Loss of appetite, Increased sweating, Dizziness, Nervousness, Tremor

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Molecule Description

Desvenlafaxine is a prescription medicine used for depression. It is the primary active metabolite of venlafaxine. It also increases the amount of chemical serotonin in the brain, which improves the patient's mood and symptoms of depression.

Uses

Treatment of depression

Contraindications

When should one not use Desvenlafaxine

If you are allergic to Desvenlafaxine or any of the other ingredients of this medicine
If you are taking, or have recently taken, monoamine oxidase inhibitors (MAOIs)
Desvenlafaxine is unsuitable for children under 18

Side effects

Common side effects of this drug are:

Nausea
Fatigue
Dryness in mouth
Loss of appetite
Increased sweating
Dizziness
Nervousness
Tremor

Precautions and Warnings

Pregnancy

Desvenlafaxine can have potential side effects on the baby and can be unsafe to use during pregnancy. The limited human studies on Desvenlafaxine show the risk of congenital disabilities in the baby. Seek medical advice before taking this medication.

Breast Feeding

Desvenlafaxine is not safe to take while breastfeeding, as it passes into the breast milk in a significant amount, which can affect the newborn. Seek medical advice before taking this medication. In such cases, breastfed babies should be closely checked as not many studies are available.

Driving

No, you should not drive while using Desvenlafaxine, as it decreases alertness. Desvenlafaxine can cause drowsiness, dizziness, difficulty concentrating, and fatigue. So, don't perform activities that require mental alertness and physical strength, such as driving.

Alcohol

No, you should not consume alcohol with Desvenlafaxine as it increases the effect of drowsiness, dizziness, difficulty in concentration, fatigue.

Other General Warnings

Talk to your doctor if

You have to start other medicines.
You get self-harming thoughts.
You want to stop the medicine. Sudden stoppage of Desvenlafaxine can cause withdrawal symptoms or worsening of your condition, leading to serious health issues.
Talk to your doctor about your medical history. Some conditions can make you more susceptible to side effects or intensify them.
Desvenlafaxine should not be given to children without consulting the doctor.
You have a kidney or liver disease.
You have a respiratory disease.
You have a cardiovascular disease.
You have diabetes mellitus.
You have seizure disorders.
You have suicidal tendencies or a history of suicidal thoughts.

Mode of Action

How Does It Work?

Desvenlafaxine functions by increasing the amount of a chemical in the brain called serotonin. It is responsible for mood stabilisation and happiness. It also helps in sleeping, healthy eating, and digestion. Serotonin deficiency leads to depression and anxiety. Desvenlafaxine enables you to sleep better, enhances your mood, and relieves worry and tension. It blocks serotonin reuptake, which increases serotonin levels in the synaptic cleft and relieves depression and anxiety.

Interactions

Interactions with other medicines

When serotonergic agents interact with Desvenlafaxine, it leads to serotonin syndrome.
It is contraindicated to take Monoamine Oxidase Inhibitors with Desvenlafaxine.

Interactions with food items

Desvenlafaxine does not show any interaction with food.

Dosage

Overdose

Don't take Desvenlafaxine more than the given dose by the clinician. Overdosing will not relieve the symptoms; instead, it will lead to toxicity in the body. It can lead to serious side effects. In case of overdose, seek emergency medical help.

Missed a Dose

If you have missed the dose of Desvenlafaxine, take it just when you remember. If it's nearing the time for the next dose, take the next scheduled dose. Don't take excessive doses to compensate for the missed dose. Don't stop or change the dose of Desvenlafaxine without a clinical consultation.

Frequently Asked Questions (FAQs)

Yes, Desvenlafaxine can cause sleepiness, drowsiness, difficulty concentrating, dizziness and fatigue. So, don't perform activities that require mental alertness and physical strength, such as driving.

There is no evidence of dependency with Desvenlafaxine, but sudden stoppage can cause withdrawal symptoms like anxiety, dizziness, sleep disturbances, restlessness, palpitations etc.

No, if your symptoms deteriorate, consult your doctor. Do not discontinue this medicine instantly. Sudden stop of this medicine can result in withdrawal symptoms or the development of severe side effects, which can lead to serious health issues.

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