Dapagliflozin+Sitagliptin

When should one not use Dapagliflozin+Sitagliptin

Common side effects of this drug are:

• Headache
• Dizziness
• Low blood sugar
• Rashes
• Painful urination
• Urinary tract infection
• Genital fungal infection
• Nasal congestion
• Sore throat

Other General Warnings

• You have type 1 diabetes or a complication of diabetes called diabetic ketoacidosis.
• You develop symptoms of acute pancreatitis like continuous and severe abdominal pain after using this medicine.
• You are taking other anti-diabetic medicines like sulphonylureas or insulin. If you are not sure what these medicines are, please confirm with your doctor.
• You develop allergic reactions like swelling of the face, tongue and lips after using Dapagliflozin+Sitagliptin.
• You experience itchy skin with large blisters after taking this medicine.
• You have kidney disease or are on dialysis.
• You have liver disease or heart failure.
• You are taking medicines for managing high blood pressure.
• You have a history of low blood pressure or are elderly ((≥ 65 years).
• You have any illness of the stomach or intestine.
• If you develop symptoms like nausea, vomiting, abdominal pain, excessive thirst, confusion, sleepiness and tiredness after taking this medicine, talk to your doctor immediately.
• You are scheduled for surgery.
• You are dehydrated or have restricted food intake.
• You take alcohol regularly or frequently.
• You notice pain, tenderness, red or pink blotches on the skin, or swelling in the genital or perineal area, with fever or general discomfort after taking Dapagliflozin+Sitagliptin. Talk to your doctor immediately.
• You have an infection of the urinary tract.
• You develop blisters or ulcers on your foot while taking Dapagliflozin+Sitagliptin. Talk to your doctor immediately.

How Does It Work?

• Dapagliflozin+Sitagliptin contains a combination of sitagliptin and dapagliflozin as active substances.
• Sitagliptin indirectly increases the activity of certain chemicals in the body that increase the levels of insulin after a meal.
• Dapagliflozin blocks a certain protein in the kidneys called sodium-glucose co-transporter 2 (SGLT-2), which is responsible for the reabsorption of glucose (sugar) from the urine into the blood. This causes the removal of sugar through the urine, thereby reducing the level of blood sugar.

Interactions with other medicines

• Some medicines can affect the way Dapagliflozin+Sitagliptin works or this medicine itself may interfere with the working of other medicines.
• Inform your doctor about all other medicines, herbals or supplements that you are currently taking or might take to avoid any possible interaction.
• Particular care should be taken if you have kidney disorders and are taking medicines for the treatment of fungal infections (ketoconazole), bacterial infections (clarithromycin) or HIV/AIDS (ritonavir).
• Caution should be exercised if you are taking medicines for the management of heart failure (digoxin).
• The use of Dapagliflozin+Sitagliptin with diuretics like furosemide and hydrochlorothiazide (used to manage fluid accumulation) may increase the risk of dehydration and low blood pressure.
• This medicine, when used together with insulin and insulin secretagogues (sulphonylurea), may cause extremely low blood sugar levels.

Overdose

Missed a Dose

• If you missed a dose of Dapagliflozin+Sitagliptin, take it as soon as you remember.
• If it's time for your next dose, then skip the missed dose and continue with your regular dosing schedule.
• Do not take a double dose to compensate for the missed dose.