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Chlordiazepoxide+Clidinium

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Molecule Summary

Uses
Irritable bowel syndrome, chronic irritable colon, spastic constipation, mucous colitis, spastic colitis, abdominal pain, cramping, bloating, diarrhoea, constipation, easy passage of gas, anxiety and tension associated with irritable bowel syndrome
Therapy
Drugs For Irritable Bowel Syndrome
Side Effects
Sleepiness, Drowsiness, Fatigue, Confusion, Uncoordinated body movements, Abnormality of voluntary movements, Skin rash, Slurred speech, Bone marrow depression, Hypersensitivity, Urinary retention, Urine incontinence, Libido disorders, erectile dysfunction, menstrual disorder, Visual impairment
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NPPA
Regulated

Molecule Description

Chlordiazepoxide+Clidinium is used to treat the symptoms of irritable bowel syndrome and other conditions that are related to irritable bowel syndrome like chronic irritable colon, spastic constipation, mucous colitis, and spastic colitis. This medicine facilitates easy passage of gas from the stomach, which relieves stomach discomfort. Chlordiazepoxide+Clidinium also prevents sudden muscle spasms and this helps to relieve stomach pain.

Uses

  • Irritable bowel syndrome
  • Chronic irritable colon
  • Spastic constipation
  • Mucous colitis
  • Spastic colitis
  • Abdominal pain
  • Cramping
  • Bloating
  • Diarrhoea
  • Constipation
  • Anxiety due to irritable bowel syndrome
  • Gaseous distension due to irritable bowel syndrome

Contraindications

When should one not use Chlordiazepoxide+Clidinium

  • Hypersensitivity
  • Urticaria
  • Angioedema
  • Face oedema
  • Exanthema
  • Severe pulmonary insufficiency
  • Respiratory depression
  • Pregnancy
  • Depression
  • Anxiety with depression
  • Paralytic ileus
  • Vaginal bleeding or discharge
  • Difficulty in Urination
  • Fever
  • Constipation
  • Blood in Stools
  • Myasthenia Gravis (Muscle Weakness)
  • Anxiety Disorders
  • Schizophrenia
  • Manic Depression
  • Sleep Apnoea
  • Spinal Or Cerebral Ataxia
  • Kidney Diseases
  • Liver Problems
  • Porphyria
  • Psychotic disorder
  • Alcoholism
  • Thrombocytopenia
  • Young children

Side effects

Common side effects of this drug are:

  • Common:
  • Sleepiness
  • Drowsiness
  • Fatigue
  • Confusion
  • Uncoordinated body movements
  • Abnormality of voluntary movements
  • Skin rash
  • Slurred speech
  • Nausea
  • Vomiting
  • Headache
  • Heartburn
  • Indigestion
  • Constipation
  • Dizziness
  • Rare:
  • Bone marrow depression
  • Hypersensitivity
  • Urinary retention
  • Urine incontinence
  • Libido disorders
  • Erectile dysfunction
  • Menstrual disorder
  • Visual impairment
  • Several side effects can occur with Chlordiazepoxide+Clidinium. Most of these side effects disappear over time without any medical attention. However, if they persist or worsen, speak to your doctor.

Precautions and Warnings

Pregnancy

Pregnancy

Chlordiazepoxide+Clidinium is not recommended during pregnancy as there is limited or no data from its use in pregnant women. Studies on animals, which look at reproductive toxicity, are insufficient.

Breast Feeding

Breast Feeding

It is not recommended to take Chlordiazepoxide+Clidinium during breastfeeding or lactation as there is no sufficient data about it.

Driving

Driving

Chlordiazepoxide+Clidinium may cause drowsiness, dizziness and confusion. Avoid driving or operating machinery until you know how this medicine affects you.

Alcohol

Alcohol

It is not safe to consume alcohol with Chlordiazepoxide+Clidinium as it causes some adverse effects like increased heartbeat, fainting, and heartburn.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You are not hydrating yourself while taking this medicine.
  • You are not eating a fibre-rich diet while taking this medicine.
  • You smoke or drink alcohol while taking this medicine.
  • You eat oily or spicy foods.
  • You have a bleeding disorder.
  • You have liver disease.
  • You have kidney disease.
  • You have lung problems.
  • You have breathing problems.
  • You have sleep apnoea.
  • You have Chronic Obstructive Pulmonary Disease (COPD) - a chronic inflammatory lung disease that obstructs the airflow from the lungs.

Mode of Action

How Does It Work?

Chlordiazepoxide+Clidinium is a combination of two drugs named Chlordiazepoxide and Clidinium. Clidinium relieves stomach cramps and intestinal cramps. Moreover, it also helps to relax the muscles in the stomach and intestines by acting as an antispasmodic, thus slowing the natural movements of the gut. Whereas on the other hand, Chlordiazepoxide being a benzodiazepine, suppresses excessive or abnormal behaviour of the brain's nerve cells by increasing the action of a chemical messenger (GABA).

Interactions

Interactions with other medicines

  • Centrally acting drugs
  • Narcotic analgesics
  • Anti-epileptic drugs
  • Antihypertensives, vasodilators & diuretics
  • Antacids
  • Antidepressants

Interactions with food items

  • Spicy and oily food
  • Alcohol consumption

Dosage

Overdose

In cases of overdose, CNS excitability may be observed. You may experience neurological and cardiovascular symptoms as side effects. Symptoms of overdose include drowsiness, confusion, problems with coordination, and loss of consciousness. These symptoms can range in severity from mild to severe. Hence, seek medical advice the moment you experience these symptoms of overdose.

Missed a Dose

Patients who miss one or more doses should continue with their regular dosage. They should not take the missed dosage plus the regular dosage.

Frequently Asked Questions (FAQs)

Chlordiazepoxide+Clidinium contains Chlordiazepoxide as an ingredient, which can cause physical dependence. Physical dependence is defined as a withdrawal reaction following the abrupt discontinuation or decreased dosage of the drug.

Chlordiazepoxide+Clidinium doesn't have a laxative effect alone. It can, however, be used in combination with ispaghula husk to treat constipation associated with irritable bowel syndrome.

No, you will not lose weight while taking this medicine.

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