Ceftazidime+Tazobactam

Uses	Bacterial infections
Therapy	Antibiotic
Side Effects	Diarrhoea, constipation, nausea, vomiting and indigestion

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Molecule Description

Ceftazidime+Tazobactam is an antibiotic medicine used in hospitals to treat serious bacterial infections. These include infections in the respiratory tract, urinary tract, skin and soft tissue, intra-abdominal infections, septicemia, and bacterial meningitis. It is typically prescribed only when other antibiotics are ineffective. This medicine is a combination of ceftazidime and tazobactam. Ceftazidime works by destroying the bacterial cell wall, thereby helping to stop the infection. Tazobactam supports ceftazidime by blocking substances that bacteria use to resist antibiotics, making the treatment more effective. Some people may experience side effects like diarrhoea, nausea, headache, skin rashes, or pain at the injection site. Tell your doctor if you have allergies to antibiotics or if you have kidney issues. Also, let your doctor know about any other medicines you are taking, especially those for cancer, gout, or if you're using birth control, as they can interact with Ceftazidime+Tazobactam. This medicine is administered by a doctor or nurse; never attempt to self-inject it. If you're pregnant or breastfeeding, consult your doctor first. Avoid driving if you feel dizzy or drowsy after the medicine. Always store it properly and keep it out of children's reach. If you feel unwell after receiving the medicine, such as experiencing seizures, vomiting, or persistent diarrhoea, please inform your doctor immediately.

Uses

Respiratory tract infections
Urinary tract infections
Skin and soft tissue infections
Intra-abdominal infections
Septicaemia
Bacterial meningitis (inflammation of the meninges that cover the brain and spinal cord)

Contraindications

When should one not use Ceftazidime+Tazobactam

If you are allergic to ceftazidime, tazobactam or any other ingredients of Ceftazidime+Tazobactam.
If you have a history of a severe allergic reaction to any other antibiotics, like penicillins.

Side effects

Common side effects of this drug are:

Diarrhoea
Blood disorders, such as a decrease in blood count, excessive platelets in the blood
Constipation
Nausea
Vomiting
Indigestion
Stomach pain
Fever
Anaemia
Fungal infection (candidiasis)
Headache
Sleeplessness
Rashes
Itching
Inflammation and swelling at the injection site

Precautions and Warnings

Pregnancy

It is not advisable to take this medicine during pregnancy as it passes the placental barrier. However, it can be given to you by your doctor if required after assessing the benefits over risks. Consult your doctor if you are pregnant, think you may be pregnant or are planning to have a baby.

Breast Feeding

The components of this medicine pass into breastmilk and are known to cause fungal infections of the mouth and diarrhoea in babies. Consult your doctor if you are breastfeeding, as they will advise you on the use of this medicine after assessing the benefits and risks.

Driving

This medicine may affect your ability to drive or operate machines. Do not drive or operate machines if you experience dizziness and drowsiness.

Alcohol

Although there is no known interaction between alcohol and this medicine, it is essential to consult your physician if you have a habit of consuming alcohol regularly.

Other General Warnings

Talk to your doctor if

You have a history of allergy to penicillins or any medicines; as much caution is required in such patients.
You experience any allergic reaction due to the use of this medicine, the doctor may discontinue the medicine quickly.
You experience diarrhoea as a side effect of this medicine, a doctor may discontinue the treatment and switch to an alternative medication.
You may develop a kidney problem.
You experience bleeding disorders or are taking blood-thinning medicines like Warfarin.
You experience fits or convulsions.

Mode of Action

How Does It Work?

Ceftazidime acts by inhibiting bacterial cell wall synthesis, which is essential for their survival. Therefore, it leads to the death of the cell. Hence, it helps stop the growth of bacteria and prevent infection.
Tazobactam is a medication that enhances the effectiveness of certain antibiotics. It does this by blocking an enzyme (called beta-lactamase) made by some bacteria that can destroy antibiotics. By inhibiting this enzyme, tazobactam protects the antibiotic and enhances its ability to kill bacteria more effectively.

Interactions

Interactions with other medicines

Medicines used to relax the muscles during surgery, like Vecuronium.
Medicines used to treat certain types of cancer, such as methotrexate.
Medicines used to treat gout include probenecid.
If you have kidney problems and are taking antibiotics such as Tobramycin, Gentamicin, and Vancomycin.
Concomitant use of antibiotics like chloramphenicol, gentamicin, tobramycin, and water pills like furosemide can cause adverse effects on the kidneys and gut flora or the digestive tract.

Dosage

Overdose

Your doctor or nurse will give this medicine. Therefore, it is less likely to provide you with more or less of this medicine. However, if you experience loose motions, nausea, vomiting and fits immediately after receiving this medicine, inform your doctor as soon as possible.

Missed a Dose

You will be monitored by the doctor or nurse as to when Ceftazidime+Tazobactam should be given to you. Thus, it is unlikely that a dose of the medicine will be missed. If the doctor or nurse might have missed a dose, inform them.

Frequently Asked Questions (FAQs)

Kidney damage can happen when using Ceftazidime+Tazobactam. Call your healthcare provider immediately if you experience any symptoms of kidney damage.

It can cause tiredness or weakness in some people. Tell your doctor if you have fever, chills or sore throat, any unexplained bruising or bleeding, or feel very tired or weak. Also tell your doctor about redness or white patches in the mouth or throat, or vaginal itching or discharge. Diarrhoea is common with antibiotics.