Carboplatin

Molecule Description

Carboplatin is different from other Cisplatin medicine. It contains a Bidentate

Dicarboxylate (two atoms that coordinate directly to the central atom), instead of two Chloride Ligands. It is lower in reactivity and takes time to bind to the DNA. The slow cohesion allows the drug to remain in the body for more extended periods.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Carboplatin

Treat ovarian cancer
Treat testicular cancer, head and neck cancer, cervix cancer, small cell lung cancer, progressive diffuse large B-Cell lymphoma, neuroblastoma (cancer that forms at specific types of nerve tissues)

Contraindications of Carboplatin

When should one not use Carboplatin

Allergic reaction to platinum-based medicineIf you have kidney disease
Patients who have severe bleeding issues
If you have a tumour that bleeds
If you plan to receive a yellow fever vaccination or have just received one

Side effects of Carboplatin

Common side effects of this drug are:

Hair loss
Bleeding
Stomach pain and cramp
Itchy and rashes on the skin
Feeling dizzy
Breathlessness
Pain in the back and chest
Shivering
Feeling flushed or hot
Sore lips or mouth ulcers
Anemia (decreased number of red blood cells)
Thrombocytopenia (decreased platelet count)
Neutropenia (decreased neutrophil count)
Abnormal liver enzyme levels
Decrease in the level of sodium, potassium, calcium, and magnesium in your blood
Nephrotoxic (damaging to kidneys) - Lesser nephrotoxic side effects as compared to other forms of chemotherapy
WBC count will dip drastically; this leads to common issues such as fever or infections. The latter’s symptoms include sore throats, diarrhea, cough and shivers

Precautions and Warnings of Carboplatin

Pregnancy

Can I take Carboplatin during pregnancy?

This medicine is not recommended to use during pregnancy.

Breast Feeding

Can I take Carboplatin while breastfeeding?

This medicine should not be administered to the women who are lactating or breastfeeding.

Driving

Can I drive if I have consumed Carboplatin?

Do not drive if you experience any side effect, which may reduce your ability to do so, such as nausea, vomiting, worsening of eyesight, or changes to your vision and hearing.

Alcohol

Can I consume alcohol with Carboplatin?

The interaction with alcohol is unknown, but a consultation with a doctor is advisable.

Other General Warnings

Talk to your doctor if

If you notice a decrease in sensation and numbness, it is a part of the treatment
If you have any form of an allergic reaction to platinum-based formulation, avoid taking Carboplatin
Do not take any vaccine during treatment and consult your doctor before you do so
Make sure the patient discloses all information regarding the consumption of any other medicines to the doctor, especially over the counter medicines and anything that contains Aspirin

Mode of Action of Carboplatin

How Does It Work?

The drug works by binding with the strands of the cancer cell’s DNA. It damages the DNA and stops the cells from multiplying. Unfortunately, it also has the same effects on normal healthy cells, which...

Interactions of Carboplatin

Interactions with other medicines

Severe interactions with Clozapine and live vaccines
Milder interactions with Vancomycin and Atorvastatin
Aminoglycoside antibiotics (e.g., Gentamicin, Neomycin)
Amphotericin B
Anti-seizure medications (hydantoins such as Phenytoin)
Water pills (loop diuretics such as Bumetanide, Furosemide)
Nalidixic acid
Blood-thinning medicines e.g., Warfarin
Other medicines which decrease the activity of the immune system (e.g.Ciclosporin, Tacrolimus, Sirolimus)

Interactions with food items

There are no known food interactions available for this medicine, but you must consult your doctor.

Dietary Restrictions of Carboplatin

It has diet restrictions, but it is advised to drink ample amounts of fluid.

Dosage of Carboplatin

Overdose

The symptoms of overdose include difficulty in breathing, and the patient might collapse, contact a doctor immediately in case of such an event.

Missed a Dose

It is important to receive each scheduled dose of this medicine as directed. If you miss a dose, contact your doctor or pharmacist right away to establish a new dosage schedule.

Frequently Asked Questions (FAQs)

Q: How do you know the right dosage for every individual?

A: A formula called Calvert’s formula is used to calculate the dosage for every individual, which factors in the creatine clearance and the desired area under the curve.

Q: Should you consume more fluids during treatment?

A: You are supposed to consume at least two to three quarts of fluid every 24 hours during treatment.

Q: Where was Carboplatin developed?

A: It was discovered at Michigan State University and developed in The ICR, London. It was approved for usage and sales in 1989. In 2004, various versions of the drugs was made available for public usage.

Q: How long does the administration for each dosage last?

A: Each dosage takes around 15-60 minutes to be given through injection. The duration of your treatment is dependent on the severity of your condition.

Q: Should you use contraceptives during treatment?

A: Yes, you should under no circumstance conceive during treatment as it can be fatal for the foetus.

References

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Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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आंवला (Gooseberry in Hindi) के उपयोग, फ़ायदे और न्यूट्रिशनल वैल्यू

परिचय वानस्पतिक नाम एम्ब्लिका ऑफिसिनैलिस आमतौर पर आंवला को इंडियन गूजबेरी (भारतीय करौंदा) कहा जाता है। इन पेड़ों की बेरी को इनके औषधीय गुणों के कारण औषधीय फार्मूलेशन में प्रयुक्त किया जाता है। आंवला के पेड़ पर छोटी बेरीज़ होती हैं जो गोल और पीले-हरे रंग की होती है। इसके कई स्वास्थ्य फ़ायदों के कारण

केला (Banana in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: “एक दिन में एक केला (बनाना) खाने से मेरा एंडोर्फिन लेवल बना रहता है।” बनाना (मूसा प्रजाति) या केला एक लंबा, पीला फल है जो वास्तव में एक बेरी है। यह मुसासी (मुसासेई) परिवार से संबंधित हैं और इसमें मूसा एक्यूमिनाटा, मूसा बालबिसियाना आदि किस्में शामिल हैं। यह दक्षिणी एशिया के उष्णकटिबंधीय क्षेत्रों (ट्रॉपिकल

सौंफ (Fennel Seed in Hindi) : उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: सौंफ (फेनल सीड) का वैज्ञानिक नाम फीनीकुलम वल्गारे है और यह एपोकिनेसी परिवार से संबंधित एक सुगंधित पौधा है।1 सौंफ (फेनल सीड) की एक अलग आकृति, आकार और रंग होता है; यह लंबी, पतली होती है और हल्के हरे या भूरे रंग की होती है। सौंफ (फेनल सीड) का पौधा इसके बीजों, पत्तियों और

ड्रैगन फ्रूट (Dragonfruit in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

ड्रैगन फ्रूट कैक्टस प्रजाति का फल होता है जिसके स्वास्थ्य से जुड़े कई लाभ होते हैं जैसे कि रक्त शर्करा (ब्लड शुगर) के जोखिम को कम करना, पाचन (डाइजेशन) में मदद करना आदि। यह एक ड्रैगन की तरह दिखता है और इस वजह से इसका यह नाम पड़ा। अब आप सोच रहे होंगे कि इस

तेजपत्ता (Bay Leaves in Hindi)– उपयोग, फायदे और न्यूट्रिशनल वैल्यू

परिचय तेजपत्ता सिनामोमम तमाला नामक पौधे की सूखी पत्तियां होती हैं। यह सिनामोमम वंश के लौरेसी परिवार का पौधा होता है जिसकी 270 प्रजातियां हैं और प्रमाणिक रूप से ये सभी एशिया और ऑस्ट्रेलिया में पाई जाती हैं। तेजपत्ता को भारतीय बे-लीफ़ भी कहा जाता है जो छोटे सदाबहार या बारहमासी वृक्ष पर होते हैं

नाशपाती (Pear in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू आदि!

परिचय: नाशपाती का वैज्ञानिक नाम पायरस कमिनिस एल है। यह रोज़ेसी फ़ैमिली से संबंधित है। नाशपाती को सेब के बाद सबसे ज्यादा पौष्टिक फल माना जाता है। यह विटामिन आहार फाइबर, एमिनो एसिड, एवं क्वेरसेटिन का बढ़िया स्रोत होता है। नाशपाती अपने मिठास, सुगंध, कुरकुरेपन और ख़ास खुशबू के लिए जाना जाता है। मूल रूप

सीए 125 टेस्ट (महिलाओं के लिए) (CA 125 Test (For Women) in Hindi): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: सीए 125 टेस्ट का इस्तेमाल शरीर में सीए 125 प्रोटीन के स्तर का पता लगाने के लिए किया जाता है, जो कैंसर का पता लगाने में मददगार साबित हो सकता है। नमूना प्रकार खून उपवास \ खाली पेट रहना जरूरी: नहीं उपनाम: कैंसर एंटीजन 125 टेस्ट, सीए-125 ट्यूमर मार्कर, सीए 125 ब्लड टेस्ट। सीए

सीरम इलेक्ट्रोलाइट्स (Serum Electrolytes): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: एक सीरम इलेक्ट्रोलाइट परीक्षण आपके खून में मौजूद इलेक्ट्रोलाइट्स के स्तर को मापने की एक विधि है। इससे किडनी या दिल की समस्याओं जैसी कई बीमारियों का निदान करने में मदद मिल सकती है। आपको यह परीक्षण कितनी बार लेना चाहिए? कोई विशिष्ट आवृत्ति नहीं है। डॉक्टर आमतौर पर सीरम इलेक्ट्रोलाइट परीक्षण को मेटाबोलिक

हींग (Asafoetida in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू और अन्य बातें!

परिचय दुनिया के बहुत से हिस्सों में, हींग (ऐसाफ़ेटिडा) को खाने का स्वाद बढ़ाने वाले तत्व के रूप में और विभिन्न प्रकार की बीमारियों का पारंपरिक रूप से उपचार करने के लिए किया जाता है। हींग (फ़ेरुला ऐसाफ़ेटिडा), एक ओलिओ-गम-रेज़िन है जो अंबेलीफेरा फ़ैमिली के फ़ेरुला पौधों के तनों में बनती है। फ़ेरुला के पौधे

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