Cabergoline
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Molecule Description
Cabergoline is a ‘Dopamine Agonist,’ which is used to treat Parkinson’s disease (a disease of the brain that causes tremors).
Uses
Treat symptoms of a nerve disorder due to deficiency of Dopamine (Parkinson’s disease) in whom other treatment options were not effective. Cabergoline can be used alone or in combination with other medicines for the purpose.
Contraindications
When should one not use Cabergoline
- Allergy to Cabergoline or any components of the medicine, or to other medicines of the similar group called ‘Ergot Alkaloids’
- Any disease of the heart valves (long term usage of Cabergoline also can affect the heart valves)
- History of stomach, lung or heart disorders
Side effects
Common side effects of this drug are:
- Heart valve and related problems, infection of the lining of the heart (pericarditis) – difficulty in breathing, pounding heartbeat (palpitations), pain in the chest, back and hip region, swelling of legs (serious)
- Feeling sick (nausea), accumulation of fluid causing swelling of feet and ankles
- Vomiting, digestion problems, stomach pain, irritation of lining of the stomach, constipation, low blood pressure, sleep disturbances, confusion, headache, dizziness, spinning of head, weakness, breathing difficulty, abnormal liver function tests
- Strong feeling or impulse to do things which you would not do normally – gambling, increased sexual drive, excessive spending, shopping or eating
- Severe allergic skin reactions causing rashes, itching, burning, redness, swelling, muscle spasms (hard and painful), fatigue, psychiatric disorders (uncommon)
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- Heart, lung or liver problems
- Reduced blood supply to hands and feet in cold conditions (Raynaud's disease)
- Ulcers or bleeding of the stomach and intestines
- Psychiatric disorders
- Growth of scar tissue (fibrosis) in the heart, lungs or the stomach
- Regular monitoring of heart, lungs, kidneys, and blood is required, especially if long-term treatment with Cabergoline is planned
Mode of Action
How Does It Work?
Dopamine is a substance secreted in the brain that transmits signals (neurotransmitters), whose primary function is to regulate movements. Cabergoline acts by increasing Dopamine levels in the brain and makes movements more co-ordinated.
Interactions
Interactions with other medicines
- Cabergoline may interact with medicines used to treat migraine (Ergot medicines), sickness or vomiting (Metoclopramide), mental illness (Prochlorperazine, Chlorpromazine, Haloperidol, Chlorprothixene)
- Antibiotics (Erythromycin, Clarithromycin)
Interactions with food items
You are advised to take Cabergoline with food and a glass of water.
Dosage
Overdose
Unintentional overdose with Cabergoline may not be harmful. But if you experience any side effects such as stomach pain, low blood pressure, vomiting, or any behavioral changes, consult your doctor.
Missed a Dose
Take the missed dose as promptly as you remember. Skip the missed dose if it is too late, but do not take extra medicine to compensate for the missed dose.
Frequently Asked Questions (FAQs)
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