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Bupivacaine

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Molecule Summary

Uses
Local anaesthesia
Therapy
Local Anaesthetic
Side Effects
Drop in blood pressure, nausea, vomiting, high blood pressure, slow heartbeat, difficulty in passing urine
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Molecule Description

Bupivacaine is an anaesthetic medicine that is used to numb (anaesthetise) parts of the body and provide pain relief. It belongs to the group of medicines called anaesthetics. It can be used to numb parts of the body during surgery in adults and children above 12 years, and to relieve pain in adults, infants and children above 1 year of age.

Uses

  • To produce numbness at the site of injection.
  • It is injected around a nerve to block the nerve and relieve pain
  • It is injected around the spinal cord to prevent or relieve labour pain or caesarean section or post-operative pain.

Contraindications

When should one not use Bupivacaine

  • If you are allergic to bupivacaine or any other local anaesthetic or any other ingredient of Bupivacaine.
  • If you have any kind of skin infection with pus.
  • If you have poor blood circulation to the heart, low blood pressure, weak pulse, sweating or confusion.
  • If you have any blood clotting-related disorder or you are taking any anti-coagulants.
  • If you are suffering from any kind of infection, spinal or brain tumour.
  • If you have bleeding inside the head.
  • If you have increased pressure within the brain.

Side effects

Common side effects of this drug are:

  • Low blood pressure
  • Nausea
  • Vomiting
  • High blood pressure
  • Slow heart beat
  • Difficulty in passing urine

Precautions and Warnings

Pregnancy

Pregnancy

There is limited information on the use of Bupivacaine in pregnancy. However, it can be recommended during pregnancy only if your doctor considers it essential.

Breast Feeding

Breast Feeding

It is not known if Bupivacaine passes into breast milk. To avoid any harm to the breastfeeding infant consult the doctor if you are breastfeeding before initiating therapy and he may suggest discontinuing breastfeeding.

Driving

Driving

This medicine will cause numbness to your body. So you should avoid driving or doing any physical activity and wait for the effect to wear off.

Alcohol

Alcohol

There is no known interaction between alcohol and Bupivacaine. However, it is important to consult your doctor if you drink too often.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have any kind of underlying medical condition such as liver or kidney problem, poor blood circulation to the brain, tumour in the womb or ovary, fluid accumulation around the lungs etc.
  • You have any kind of heart condition that affects your heart rate.
  • You have low blood pressure.
  • You experience shortness of breath due to a tumour in your stomach.
  • You are elderly.
  • You are pregnant.
  • You have a history of high blood pressure or excess fluid in the womb during pregnancy.
  • You have excess fat in your body.
  • You experience symptoms like sweating, confusion, dizziness due to dehydration or severe blood loss.

Mode of Action

How Does It Work?

Bupivacaine works by blocking the transmission of pain signals in the pain area by acting on the nervous system and nerves. This blockage causes the loss of pain sensation and also affects temperature, touch, deep pressure and muscle control.

Interactions

Interactions with other medicines

  • Some medicines affect the way Bupivacaine works or Bupivacaine itself reduce the effectiveness of other medicines taken at the same time. Inform the doctor about medicines, supplements or herbals you are taking or might take to avoid possible interactions.
  • In particular, if you are taking medications for controlling heart rhythm like amiodarone or any other medicine with local anaesthetic effect, anticoagulant medicine like aspirin, anti-hypertensive medicines like atenolol etc.

Dosage

Overdose

Bupivacaine will be given by a doctor or nurse thus the chances of an overdose are unlikely. However, if you experience any discomforts inform the doctor.

Missed a Dose

It is unlikely that the dose of Bupivacaine will be missed if you are monitored in a healthcare setup. However, if you have missed taking a dose of the medicine, inform the doctor or nurse immediately.

Frequently Asked Questions (FAQs)

Bupivacaine belongs to the group of medicines called 'amide-type anaesthetics'.

Bupivacaine works by blocking the transmission of pain signals from the nerves to the brain. This helps to decrease the sensation of pain.

Yes, it might affect blood pressure. So it is advised to inform the doctor if you have a medical condition of hypertension or have a history of high or low blood pressure during pregnancy before starting the treatment.

No, it is not recommended for pregnant women unless the doctor strictly considers it essential.

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