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Anastrozole

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Molecule Summary

Uses
Breast cancer
Therapy
Anti-Neoplastic
Side Effects
Reduced appetite, nausea, diarrhoea, headache
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Molecule Description

Anastrozole is a prescription medication. It is primarily used in treating breast cancer in post-menopausal women. Breast cancer is one of the most common cancers among women, and Anastrozole helps slow down or halt the growth of cancer cells by reducing the levels of oestrogen in the body. This medicine works by blocking the enzyme aromatase, which is responsible for oestrogen production. Since some types of breast cancer depend on oestrogen to grow, lowering its levels aids in controlling the spread of the disease. Anastrozole is typically prescribed as part of a long-term treatment plan, and its benefits are maximised when taken regularly according to your doctor's instructions. You should take Anastrozole exactly as prescribed. The dose and duration will be determined by your doctor based on your condition. It should be swallowed whole with a glass of water, preferably after meals to minimise stomach upset. Do not skip doses and never take more than the recommended amount. If you miss a dose, take it as soon as you remember unless it is nearly time for your next dose. Like all medications, Anastrozole may cause some side effects, although not everyone experiences them. Common side effects may include hot flushes, joint pain, tiredness, nausea, or weakness. Inform your doctor if any side effects persist or become bothersome. Regular follow-ups and health check-ups are crucial while using this medicine to monitor your response and overall health. Before starting treatment with Anastrozole, inform your doctor if you have any history of liver or kidney problems, osteoporosis, heart conditions, or if you are taking other medicines. This medicine is not intended for use in pre-menopausal women, pregnant women, or breastfeeding mothers. Following your doctor's advice, maintaining a healthy diet, and exercising regularly can support your recovery and enhance treatment outcomes.

Uses

Anastrozole is used in post-menopausal women to treat breast cancer.

Contraindications

When should one not use Anastrozole

  • If you are known to be allergic to Anastrozole or any of the ingredients of this medicine.
  • If you are pregnant or think you may be pregnant.
  • If you are a breastfeeding mother.

Side effects

Common side effects of this drug are:

  • Reduced appetite
  • Nausea
  • Diarrhoea
  • Headache
  • Excessive sleepiness
  • Generalized weakness
  • Skin rashes
  • Hair thinning
  • Hot flushes
  • Joint pain

Precautions and Warnings

Pregnancy

Pregnancy

Anastrozole should not be used in pregnancy, as there is limited information about its safety in human pregnancy. Consult a doctor before starting any medicine during pregnancy.

Breast Feeding

Breast Feeding

The effect of Anastrozole on human milk is unknown. Hence, do not breastfeed while taking Anastrozole.

Driving

Driving

Anastrozole has a negligible influence on the ability to drive. However, muscle weakness and sleepiness have been reported with the use of anastrozole, and caution should be exercised when driving if these symptoms are experienced.

Alcohol

Alcohol

It is advisable to avoid alcohol while on treatment with Anastrozole, as both lead to excessive sleepiness and liver damage in addition to nausea.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You suffer from liver or kidney diseases, then Anastrozole should be used with caution.
  • You have any disease that affects the strength of your bones.
  • You are taking a medication that contains tamoxifen or estrogen.
  • Your periods have not yet stopped, and you have not yet gone through menopause. Your doctor might ask you to confirm your menopause by performing some blood tests if it cannot be clinically confirmed.
  • You have a known hereditary galactose intolerance.
  • You are children or adolescents.

Mode of Action

How Does It Work?

Anastrozole works by reducing the level of a natural female hormone, oestrogen, that is produced in the body. Thus, stopping the growth of the cancer cells, which depend on oestrogen for their growth.

Interactions

Interactions with other medicines

  • Anastrozole may interact with other medicines. Discuss all the medicines, supplements, or herbal preparations you are taking with your doctor. Also, inform your doctor if you have a planned surgery or a vaccination scheduled.
  • It is advisable to avoid Tamoxifen, another medicine used to treat breast cancer or other estrogen-containing therapies, while taking Anastrozole as it will reduce the effectiveness of medicines.

Interactions with food items

Anastrozole should be taken with or after having your meals.

Dosage

Overdose

Anastrozole should be taken strictly as prescribed by the doctor, in the dose and frequency specified. In case of accidental overdose, consult your doctor immediately or visit a nearby hospital.

Missed a Dose

Missing a dose of Anastrozole may reduce the effectiveness of the treatment. If you missed a dose of medicine, then take it as soon as you remember. However, if it's time for your next dose, then skip the missed dose and continue with your regular dose schedule. Do not take a double dose of medicine to compensate for the missed one.

Frequently Asked Questions (FAQs)

Anastrozole has been approved for use only in breast cancer in post-menopausal women. The long-term efficacy and safety of using Anastrozole (and similar medicines) in males have not yet been established, and their routine use is therefore not recommended.

Approximately 5 years of therapy with Anastrozole has been found to yield optimum results. However, the duration will depend on the response to treatment. Follow your doctor's instructions and do not discontinue this medication without consulting your doctor.

Yes, long-term use of Anastrozole may reduce bone mineral density, which can increase the risk of osteoporosis or fractures. Your doctor may recommend regular bone density tests, calcium/vitamin D supplements, or lifestyle changes to protect your bones.

Always inform your doctor about all medicines, vitamins, or herbal supplements you are taking. Some medicines may interfere with the effectiveness of Anastrozole or increase side effects. Your doctor will advise you on safe combinations.

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