Ambrisentan

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Molecule Description

This medicine is useful for the treatment of high blood pressure in the blood vessels that carry blood from the heart to the lungs i.e., pulmonary arteries.

Uses

Ambrisentan is useful for pulmonary arterial hypertension (high blood pressure in the blood vessels that carry blood from the heart to the lungs).

Contraindications

When should one not use Ambrisentan

Do not consume if you are allergic to Ambrisentan or any ingredient of this medicine
Do not consume if you have scarring of the lungs (Idiopathic pulmonary fibrosis)
Do not consume if you are pregnant

Side effects

Common side effects of this drug are:

Headache
Dizziness
Fast or irregular heartbeats (palpitations)
Shortness of breath
A runny or blocked nose
Feeling sick (nausea)
Diarrhea
Tiredness
Blurry or other changes to vision
Chest pain or discomfort
Flushing (redness of the skin)

Precautions and Warnings

Pregnancy

Do not use Ambrisentan during pregnancy. It may harm the unborn baby (fetus), and if one is pregnant or planning of pregnancy, consult a doctor immediately.

Breast Feeding

No information is available whether Ambrisentan is safe in breastfeeding or not. It is better to consult a doctor.

Driving

This medicine may cause side effects, such as low blood pressure, dizziness, tiredness that may affect one's driving ability.

Alcohol

No information is available on interactions of Ambrisentan when taken with alcohol, consult your doctor or pharmacist for further details.

Other General Warnings

Talk to your doctor if

You are suffering from kidney disease. Dose adjustment of this medicine may be needed
You are suffering from liver disease
You are suffering from anaemia (a reduced number of red blood cells)
You are suffering from swelling in the hands, ankle or feet
Do not take this medicine if you are suffering from lung disease (Pulmonary Veno-Occlusive disease)

Mode of Action

How Does It Work?

Ambrisentan blocks the action of Endothelin-1 (natural substance that causes blood vessels to narrow) by binding to endothelin receptors and relaxes the blood vessels that carry blood from the heart to the lungs, thus increasing the supply of blood to the lungs.

Interactions

Interactions with other medicines

Cyclosporin
Rifampicin
Epoprostenol
Iloprost
Epoprostenol
Sildenafil

Interactions with food items

No information is available on interactions of Ambrisentan when taken with food, consult your doctor or pharmacist for further details.

Dietary Restrictions

No information is available on dietary restrictions while you are taking Ambrisentan, consult your doctor or pharmacist for further details.

Dosage

Overdose

Symptoms of overdose may include chest pain, cough, shortness of breath, wheezing, swelling in hands and feet, head pain, flushing, nose block. Seek emergency medical help immediately if you overdose.

Missed a Dose

If you missed any dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose, and take the next dose at the scheduled time. Do not take extra medicine just because you missed the last dose.

Frequently Asked Questions (FAQs)

You must inform your doctor if you are suffering from any liver disease, kidney disease, lung disease, anemia, allergies, etc. Inform your doctor if you are taking any other medicines, supplements, or herbs.

Your doctor may ask you to get some routine blood tests done to check for anaemia, and to assess the functioning of your liver.

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