Teneligliptin+Metformin Hydrochloride

Uses	Diabetes
Therapy	Anti-Diabetic
Side Effects	Low blood sugar level, constipation, nausea, gas, stomach pain, diarrhoea, loss of appetite, rashes, tiredness

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Molecule Description

Teneligliptin+Metformin Hydrochloride is used to lower the high blood sugar levels in people with type 2 diabetes mellitus, along with lifestyle changes. It is a combination of two medicines, Teneligliptin and Metformin. It is an anti-diabetic medicine. This medicine works best when used along with a healthy diet and regular exercise. Teneligliptin+Metformin Hydrochloride helps you keep your sugar levels in control and reduce the risk of diabetes complications. Thus, always take this medicine as prescribed by your doctor and at the same time to get optimal benefits. Do not stop taking this medicine abruptly, as it may lead to serious health consequences. You may experience the most common side effects such as diarrhoea, nausea, vomiting, upset stomach, headache and low blood sugar level (hypoglycemia). If these side effects worsen, reach out to the nearest clinic. This medicine should not be used in patients having liver or kidney disease. Thus it is important to inform your doctor about medical conditions and lifestyle.

Uses

Teneligliptin+Metformin Hydrochloride is used to treat type 2 diabetes mellitus along with an appropriate diet and exercise.

Contraindications

When should one not use Teneligliptin+Metformin Hydrochloride

If you are allergic to Teneligliptin, Metformin or any of the ingredient of this medicine.
If you have liver or severe kidney problems.
If you are an alcoholic.
If you are in a state of diabetic coma due to a sudden rise or drop in blood sugar level.
If you have type 1 diabetes mellitus.
If you have a severe infection or you have a recent surgery.
If you have a known history of pancreatitis.

Side effects

Common side effects of this drug are:

Low blood sugar level
Nausea
Constipation
Stomach pain
Flatulence
Diarrhoea
Loss of appetite
Rashes
Tiredness

Precautions and Warnings

Pregnancy

There is limited information about the effect of Teneligliptin+Metformin Hydrochloride in pregnancy. Thus, it should be used only if prescribed by your doctor after assessing the need and benefits. Talk to your doctor if you are pregnant or think you may be pregnant.

Breast Feeding

A component of this medicine passes into the breastmilk and may cause harm to the infant. Thus, the usage of this medicine during breastfeeding is not recommended.

Driving

After taking this medicine, there are chances your blood sugar can fall. You may experience faintness, confusion and increased sweating. So, it would be best if you take extra care when driving. Keep a juice or chocolate handy while driving and in case you start experiencing any of these symptoms, immediately have it.

Alcohol

Alcohol lowers blood sugar, which can be dangerous and also increases the risk of a serious condition called lactic acidosis. Alcohol can also increase the risk of developing the serious side effect of pancreatitis.

Other General Warnings

Talk to your doctor if

You have a known history of pancreatitis or develop sudden pain in the stomach or back, immediately stop this medicine and report to the hospital.
You have a liver or heart problem like irregular heartbeat and heart failure.
You are suffering from persistent diarrhoea, vomiting and loss of body fluids.
You have serious liver and kidney function problems.
You have an irregular diet, a habit of excessive alcohol intake and intense exercise.
You have a history of any abdomen surgery.
You are using other medicines like Glimepiride because it can cause a drop in blood sugar levels.
You experience muscle pain, stomach pain, vomiting, breathing difficulty and low body temperature. It could be a serious condition known as lactic acidosis.
This medicine should not be used in children below 18 years of age.

Mode of Action

How Does It Work?

The combination of Teneligliptin and Metformin helps to regulate blood sugar levels. Teneligliptin inhibits the enzyme DPP4, which increases insulin secretion from the pancreas. Meanwhile, Metformin reduces the production of glucose from the liver, decreases glucose absorption from the intestine, and increases insulin sensitivity.

Interactions

Interactions with other medicines

If you need to take an injection of iodine-containing contrast medium into your bloodstream, for an X-ray or scan, your doctor will ask you to stop taking Teneligliptin+Metformin Hydrochloride before or at the time of injection.
You may have symptoms of low blood sugar if you are taking other medicines for diabetes like Insulin, Canagliflozin and Liraglutide.
Medicines used to treat depression like Phenelzine.
Medicines for fever and pain (salicylates like aspirin).
Medicines used to treat high blood pressure like Atenolol, Propranolol and Verapamil.
You may have high blood sugar if you are taking steroids, thyroxine.
Never take this medicine if you are taking medicines like Quinidine, Sotalol, Procainamide and Amiodarone as it may cause heart rhythm problems and cardiac arrest.

Interactions with food items

It's advisable to manage the intake of high-fiber foods around the time you take the medication to ensure optimal absorption. Limit high-sugar and high-carbohydrate foods.

Dosage

Overdose

Excess of this medicine may cause lactic acidosis characterized by vomiting, stomach and muscle cramps, difficulty in breathing.
If you think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital.

Missed a Dose

If you missed a dose of this medicine, take it as soon as you remember. If it's time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose of this medicine to compensate for the missed one.

Frequently Asked Questions (FAQs)

A diet should be high in fibre, low in fat with adequate protein, carbohydrates, vitamins and minerals. Maintain regular meal timings and try to have 2-3 healthy snacks between meals like soups and salads. Diet should include boiled, steamed or baked food. Ensure moderate use of edible oils (groundnut oil, olive oil), minimum use of ghee and butter. Drink at least 8-10 glass of water daily. Carry fruit or low-calorie high fibre biscuits while travelling.

You could be tempted to buy oily and fried food, do not shop when you are hungry. Avoid overeating. Avoid maida, white bread, potato, noodles, corn flakes, poori, biryani, naan, fried rice, etc. Decrease having daals with ghee or deep-fried pulses. Avoid cream soups, carrot juice, deep-fried vegetables and vegetable curries with excess oil.

Lactic acidosis is a condition where too much acid builds up in your bloodstream, leading to acid-base imbalance. You may experience symptoms of lactic acidosis such as abdominal or stomach discomfort, decreased appetite, diarrhoea, shallow breathing, a general feeling of discomfort, muscle pain or cramping and unusual sleepiness, tiredness or weakness.

Yes, Teneligliptin+Metformin Hydrochloride can cause Vitamin B12 deficiency when it is being used for the long-term. This medicine alters the absorption of Vitamin B12 in the stomach. Decreased absorption of vitamin B12 may result in Vitamin B12 deficiency, further resulting in anaemia and nerve problems. Decreased levels of vitamin B12 may cause tingling sensation and numbness in hands and feet, weakness, urinary problems and difficulty in maintaining balance (ataxia). It is advised to get your Vitamin B12 levels checked annually.

The composition of Teneligliptin+Metformin Hydrochloride consists of teneligliptin and metformin, as its active component, which is an anti-diabetic medicine.

You have to take Teneligliptin+Metformin Hydrochloride as long as a doctor has prescribed you. Do not stop the treatment mid-way even if you feel better, without consulting a doctor.

Teneligliptin+Metformin Hydrochloride is a combination medicine that is used to lower the high blood sugar levels in people with type 2 diabetes mellitus, along with lifestyle changes. This medicine works best when used along with a healthy diet and regular exercise. This medicine will help you keep your sugar levels in control and reduce the risk of diabetes complications.

Teneligliptin+Metformin Hydrochloride can be taken at any time of the day, as told by the doctor. But it's best to take it with a meal to reduce the unwanted effects like an upset stomach.

Low blood sugar level, nausea, constipation, stomach pain and flatulence are a few side effects that can be seen during the treatment with Teneligliptin+Metformin Hydrochloride. Although not everyone gets them. Side effects often improve as your body gets used to the medicine.

Teneligliptin works by increasing insulin secretion from the pancreas by inhibiting the enzyme dipeptidyl peptidase 4 (DPP4), whereas Metformin decreases the production of glucose from the liver, the amount of glucose absorbed from the intestine and increases insulin sensitivity.