Hydrochlorothiazide+S Amlodipine

Uses	High blood pressure
Therapy	Anti-Hypertensive
Side Effects	Headache, dizziness, sleepiness, abdominal pain

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Molecule Description

Hydrochlorothiazide+S Amlodipine is a combination medicine. It contains amlodipine and hydrochlorothiazide as active ingredients. It is used for the treatment of high blood pressure not controlled by monotherapy (individual components). This medicine works by the combined action of its two components, it relaxes the blood vessels and helps in removing the unwanted salt and water from the body. High blood pressure is a critical health condition and it is very important to take your anti-hypertensive medicines on time along with adequate dietary and lifestyle modifications. Consult your doctor for more information on this.

Uses

For the treatment of high blood pressure

Contraindications

When should one not use Hydrochlorothiazide+S Amlodipine

Known allergy to Amlodipine or Hydrochlorothiazide or any ingredient of this medicine.
If you have anuria (not passing urine or passing urine less than 100ml in a day).
If you suffer from heart failure after a heart attack, extremely low blood pressure, narrowing of a heart valve.
If you are suffering from cardiogenic shock (a condition in which your heart is not able to pump sufficient blood).

Side effects

Common side effects of this drug are:

Headache
Dizziness
Sleepiness
Abdominal pain
Weakness
Low blood pressure
Jaundice
Diarrhoea
Vomiting
Irregular blood count

Precautions and Warnings

Pregnancy

The safety of this medicine is not established in pregnancy and hence it should not be taken during pregnancy to avoid undesirable effects. Consult your doctor if you become pregnant while taking this medicine.

Breast Feeding

Components of this medicine pass into the breast milk. To avoid possible harm to the baby avoid taking this medicine if you are breastfeeding or discontinue breastfeeding if the treatment with this medicine is considered essential by the doctor. This decision should be taken by your treating doctor do not do self-analysis of your condition.

Driving

If you are unable to stay alert and have visual disturbances, headache or dizziness after taking this medicine, please avoid driving.

Alcohol

You should not consume alcohol with this medicine. Alcohol consumption while taking this medicine can lead to excessive low blood pressure.

Other General Warnings

Talk to your doctor if

You have liver or kidney related condition.
You have an autoimmune disorder called systemic lupus erythematosus.
You have heart failure, as it should be used with caution.
You are elderly, as special attention is required for elderly patients.
You are already taking any blood pressure-lowering medicine.
You are dehydrated or passing too much urine, vomiting and have excessive diarrhoea.
You are diabetic and taking anti-diabetic medicine or insulin.
This medicine may interfere with the laboratory test results of certain tests, tell your doctor or laboratory personnel.
This medicine may lead to salt or electrolyte imbalance, patients should be monitored closely.

Mode of Action

How Does It Work?

Hydrochlorothiazide+S Amlodipine works by the combined action of Amlodipine and Hydrochlorothiazide. Amlodipine works by relaxing the blood vessels thereby reduces the blood pressure inside them
Hydrochlorothiazide acts by removing excess fluid and salt from the body by increasing the urine output thus help reduce blood volume and pressure. It also reduces the load on the heart.

Interactions

Interactions with other medicines

Simvastatin (used to lower cholesterol levels), Tacrolimus and Cyclosporin (immunomodulators) may interact with this medicine and may require dose reduction.
Blood pressure-lowering effect of Hydrochlorothiazide+S Amlodipine is enhanced by certain medicines acting on the brain, antifungals (azoles) and antibiotics (erythromycin or clarithromycin) can lead to excessive low blood pressure.
Certain medicines used to treat high cholesterol such as Cholestyramine and Colestipol if taken along with Hydrochlorothiazide+S Amlodipine can reduce its absorption and reduce its desired action.
Steroidal medicines if taken along with this medicine can lead to salt imbalances particularly reduced potassium levels.
Anti-inflammatory or painkiller medicines can reduce the blood pressure-lowering action of this medicine and the patient needs to be monitored closely.
Tell your doctor about any other medicine, supplement or herbal preparation if you are taking currently or might take.

Interactions with food items

Avoid grapefruit and grapefruit juice because they can increase the effect of this medicine.

Dosage

Overdose

An overdose of this medicine can lead to salt imbalance and dehydration due to excessive urination, fast heartbeat and shock. Reach out to your treating doctor or nearby hospital as soon as possible. Try to carry the pack of the medicine for easy analysis of the extent of overdose.

Missed a Dose

You should never miss a dose of your blood pressure-lowering medicine. If you happen to miss any dose, take it as soon as you remember. Skip the missed dose if it's already time for your next dose. Do not take two doses together to compensate for the missed one.

Frequently Asked Questions (FAQs)

Hydrochlorothiazide+S Amlodipine is used for the treatment of high blood pressure along with diet and lifestyle modifications.

You should take this medicine as prescribed by your doctor. For effective blood pressure control try to take this medicine at the same time every day and do not miss any dose of this medicine.

No, you should not take other agents for controlling blood pressure along with this medicine, you should always consult your doctor before taking any other medicine, supplement or herbals while you are on this medicine.