Glynase-MF Tablet
10 Tablet(s) in Strip
Product Summary
Glynase Mf Tablet contains metformin 500 mg and glipizide 5 mg and is used to treat type 2 diabetes. USV makes this combination antidiabetic medicine. Glipizide stimulates insulin release, while metformin reduces glucose made and absorbed by the body to improve blood sugar control.
Medically Reviewed by Dr. Ritu Budania
Last updated on: 13 October 2026 | 2:14 PM (IST)
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General Information
| Therapy | Anti-diabetic |
| Composition | Metformin(500.0 Mg)+Glipizide(5.0 Mg) Metformin 500.0 Mg+Glipizide 5.0 Mg |
Metformin 500.0 Mg+Glipizide 5.0 Mg
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*Offer applicable on orders above ₹1000About Glynase
Glynase-MF tablet is an anti-diabetic medicine used for the treatment of type 2 diabetes mellitus. It contains a combination of glipizGlynase-MF is an anti-diabetic medication used to treat type 2 diabetes, a condition where the body either doesn't produce enough insulin or can't effectively use the insulin it produces. This tablet combines two medications: Glipizide, which stimulates the pancreas to release insulin and reduces glucose production in the liver, and Metformin, which helps the body use insulin more effectively and also reduces glucose production in the liver.
Glynase-MF should be taken with food at regular intervals as prescribed by your doctor to minimize stomach upset. Your doctor will determine the appropriate dosage, which may be adjusted over time based on your blood sugar levels. Common side effects include low blood sugar (hypoglycemia), nausea, diarrhea, indigestion, headache, dizziness, blurred vision, weakness, cold sweats, stomach pain, weight gain, and swelling. While not everyone experiences these side effects, seek medical attention if they occur. Lactic acidosis, a rare but serious condition caused by a buildup of lactic acid in the blood, is a potential risk, especially in people with kidney, liver, or heart disease.
Some other medications with glipizide and metformin as active ingredients include Dibizide M tablet, Glimet DS tablet, Glyson MF tablet, Glirum MF tablet and Metaglez Forte tablet. Do not skip the meal, take small but frequent meals.
Uses
Contraindications
- If you are allergic to glipizide or metformin or any other ingredients of Glynase-MF tablet.
- If you have liver or kidney problems.
- If you are an alcoholic or have any thyroid problems.
- If you have uncontrolled diabetes along with either nausea, vomiting, diarrhoea, stomach pain, deep or rapid breathing, sleepiness, weight loss, unconsciousness, etc.
- If you have any heart problems or if you recently had a heart attack.
- If you have type 1 diabetes.
- If you suffer from dehydration or severe diarrhoea or vomiting.
- If you are going to undergo any surgery or operation.
- If you have ketone bodies and sugar in your urine.
- If you have a severe infection of the lung or kidney.
- If you are pregnant, think you may be or are breastfeeding.
- If you are on an antifungal medication like miconazole.
Side effects
- Diarrhoea
- Nausea
- Upset stomach
- Dizziness
- Sleepiness
- Shakiness
- Itchy skin
- Rash
Precautions and Warnings
Alcohol
UNSAFEYou must not consume alcohol along with Glynase MF tablet, as alcohol lowers blood sugar which can be dangerous and can also increase the risk of a serious condition called lactic acidosis.
Pregnancy
UNSAFEThere is no evidence available to the show effect of Glynase MF tablet during pregnancy. In general, in pregnancy-related diabetes, insulin is preferred over any oral blood sugar-lowering medicines. Thus consult your doctor before taking this medicine.
Breastfeeding
WITH CAUTIONLimited information is available on the effects shown by Glynase MF tablet while breastfeeding. Take your doctor advise before taking it.
Driving
WITH CAUTIONGlynase MF tablet may cause low blood sugar levels, which can impair your ability to drive.Always keep sugar, juice or a bar of chocolate in your car with you while driving.In case you experience any of the symptoms of low blood glucose levels like dizziness, drowsiness, visual disturbances and sweating, stop driving immediately and have sugar/ juice.Do not consume sugar-free at such episodes.
Other General Warnings
- You have problems with your liver or uncontrolled diabetes.
- You are pregnant, planning a pregnancy or breastfeeding
- You experience signs of low blood glucose like dizziness, weakness, rapid heartbeat, sweating, and inability to concentrate.
- You experience muscle pain, stomach pain, vomiting, breathing difficulty, and low body temperature. This could be a serious condition known as lactic acidosis.
- You have G6PD deficiency (glucose-6-phosphate dehydrogenase deficiency).
- You experience severe diarrhoea, vomiting, and loss of body fluids.
- You have problems with your adrenal or pituitary glands.
- You are scheduled to have surgery or an operation.
- You consume alcohol on a regular basis.
- You develop a fever or infection.
- You eat less or exercise more than usual.
- You suffer from dehydration.
- You are above 60 years old.
- Stop taking this medicine for a short duration if you have severe vomiting or diarrhoea, fever, etc.
- Glynase-MF tablet is not recommended for use in patients less than 18 years old.
Directions for use
- Take Glynase MF tablet in the dose and duration as directed by the doctor.
- Swallow it as a whole with water. Do not chew or break the tablet.
- It should be taken with or after food.
- It would be best if you took it at a fixed time for optimal results.
- Do not consume it more than that prescribed by your doctor.
Storage and disposal
- Store Glynase MF tablet in the room temperature.
- Protect it from excess heat and moisture.
- Keep it out of reach from children and pets.
Quick tips
- Glynase MF tablet is an anti-diabetic medicine. It is used for the management of type 2 diabetes mellitus. It contains a combination of glipizide and metformin as active ingredients.
- Take this medicine in the exact dose and duration prescribed by the doctor. Do not take more than the prescribed dose.
- Headache, stomach pain, restlessness and nausea/vomiting may occur in some individuals with the use of this medicine. Inform your doctor if these effects bother you or do not go away.
- Talk to your doctor if you have kidney or liver disease.
- Along with taking Glynase MF, it is essential that you do certain lifestyle modifications like exercising regularly, avoiding smoking and drinking alcohol.
- It is also advised to have a balanced diet with adequate fruits and vegetables for good control of your blood sugar levels.
- Before starting Glynase MF tablet, inform your doctor if you are pregnant, planning a pregnancy or breastfeeding and about your detailed medical history.
Dosage
Overdose
Missed a dose
- You should never miss your blood sugar medicines as they may lead to high blood sugar and symptoms associated with that.
- If you missed any dose of Glynase MF, take it as soon as you remember.
- If it's time for your next dose, then skip the missed dose and continue with your regular dose schedule.
- Do not take a double dose of medicine to compensate for the missed one.
How Glynase works
Interactions
Interactions with other medicines
- Some medicines can affect the way Glynase MF tablet works, or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
- Tell your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
- Especially if you are taking medicines such as thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, isoniazid, furosemide, nifedipine, carbonic anhydrase Inhibitors, acetazolamide (Diamox), dichlorphenamide (keveyis), methazolamide, topiramate (Topamax, in qsymia), or zonisamide (Zonegran).
- Glynase MF tablets should not be used along with Miconazole (used to treat fungal infection) as it can cause low blood sugar leading to symptoms like fatigue, fast or irregular heartbeats, sweating or even coma.
Food interactions
Frequently asked questions
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References
- CDSCO [Internet]. Cdscoonline.gov.in. 2021 [cited 16 May 2022]
- METAGLIP [Internet]. Accessdata.fda.gov. 2021 [cited 16 May 2022]
- Metaglip, (glipizide-metformin) dosing, indications, interactions, adverse effects, and more [Internet]. Reference.medscape.com. 2021 [cited 16 May 2022]
- 5 mg Glipizide/500 mg Metformin Hydrochloride Tablets, Fasting - Full Text View - ClinicalTrials.gov [Internet]. Clinicaltrials.gov. 2021 [cited 16 May 2022]
- Glipizide and Metformin Hydrochloride Tablets, USP [Internet]. Dailymed.nlm.nih.gov. 2021 [cited 16 May 2022]
- Drugs H. Glipizide: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2021 [cited 16 May 2022]
- Glucotrol, Glucotrol XL (glipizide) dosing, indications, interactions, adverse effects, and more [Internet]. Reference.medscape.com. 2021 [cited 16 May 2022]
- Drugs H. Metformin: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2021 [cited 16 May 2022]
- Glipizide 5 mg Tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2021 [cited 16 May 2022]
- Glipizide 5 mg Tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2021 [cited 16 May 2022]
- Metformin 500mg tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2021 [cited 16 May 2022]
- Metformin 500mg tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2021 [cited 16 May 2022]
- Correa R, Quintanilla Rodriguez BS, Nappe TM. Glipizide. [Updated 2023 Jul 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan. Accessed January 1, 2025.
- Corcoran C, Jacobs TF. Metformin. [Updated 2023 Aug 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan. Accessed January 1, 2025.
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