Safronac S Tablets

• If you are allergic to aceclofenac, serratiopeptidase or any other ingredients of the Safronac tablet.
• If you have a current or repeated history of stomach ulcers or bleeding.
• If you've ever had breathing problems, a runny nose, swelling (like angioedema), or skin rashes (like hives) after taking painkillers like ibuprofen, aspirin, or other NSAIDs.
• If you have active bleeding or a condition that makes you bleed easily, this medicine is not safe for you.
• If you have renal or hepatic diseases.
• If you have severe heart failure, heart disease, poor circulation in the legs or arms, or a history of stroke, this medicine may not be suitable for you.
• If you’ve had stomach bleeding or a hole in your stomach while using other NSAIDs before.
• If you are pregnant.

• Dizziness
• Upset stomach
• Abdominal pain
• Nausea
• Diarrhoea
• Vomiting
• Allergic reactions

Other General Warnings

• You take other painkillers like aspirin or ibuprofen, or medicines for high blood pressure, such as ACE inhibitors.
• You take water pills (diuretics), heart medicines like digoxin, or lithium for mental health.
• You take methotrexate, mifepristone, steroids, blood thinners (like warfarin or clopidogrel), certain antibiotics (like quinolones), antidepressants, transplant drugs (like ciclosporin or tacrolimus), or zidovudine for HIV.
• You take diabetic medications; aceclofenac may affect your blood sugar levels. Watch for signs of low or high blood sugar.

• The tablet can be taken with or without food and swallowed whole with water.
• Take it at the same time for better results.

• Store in a cool, dry place, away from direct sunlight.
• Keep it out of reach of children and pets.

Missed a Dose

Overdose

• If you think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital.
• Taking too much of this medicine can be dangerous. It may cause symptoms like headache, nausea, vomiting, stomach pain, dizziness, ringing in the ears, sleepiness, confusion, or even fainting and seizures. In severe cases, it can lead to kidney failure, liver damage, or trouble breathing. Always follow the prescribed dose and seek medical help right away if too much is taken.

How Does It Work?

• Aceclofenac works by blocking a substance in the body (called COX-2) that helps make chemicals called prostaglandins. These chemicals cause pain, swelling, and fever. By reducing them, aceclofenac helps relieve pain, reduce inflammation, and lower fever.
• Serratiopeptidase may reduce inflammation by affecting the movement and adhesion of immune cells. It may also help clear blood clots and plaque in arteries by breaking down harmful tissue without damaging healthy cells.

Interactions with other medicines

• If administered along with Warfarin, Clopidogrel or Aspirin as well as with other natural remedies such as garlic, fish oil and turmeric, there may be an increased risk of bleeding or bruising.
• Medicines for high blood pressure or water pills may not work as well and can increase the risk of kidney problems, especially in elderly or dehydrated patients.
• Heart medications like digoxin may accumulate in the body and exacerbate heart problems.
• Combining with lithium, methotrexate, or transplant medicines can increase side effects, particularly on the kidneys.
• Using Safronac tablet within 8–12 days after mifepristone may reduce its effectiveness.
• Steroids, blood thinners, antidepressants, and certain antibiotics can raise the risk of bleeding, stomach issues, or seizures.
• Zidovudine (used in HIV treatment) may increase the risk of bleeding problems.
• Diabetes medicines may need dose adjustments as aceclofenac could affect blood sugar levels.