Ixapana 10Mg Strip Of 6 Capsules

• Ixapana 10mg capsule is used, in combination with bortezomib and dexamethasone, in the management of multiple myeloma in patients who have received at least 1 prior therapy.

• If you are allergic to panobinostat or any other ingredient of the medicine.

• Diarrhea
• Tiredness and weakness (fatigue)
• Nausea
• Vomiting
• Decreased appetite
• Fever
• Swelling in the arms or legs (peripheral edema)
• Low platelet count, low white blood cell count, low red blood cell count, and low lymphocyte count on blood tests
• Abnormal heart rhythm (arrhythmia)
• Weight loss
• Changes in blood salts such as low potassium, phosphate, sodium, calcium, and albumin
• Increased blood creatinine
• Dizziness, headache, and fainting
• Underactive thyroid gland, high blood sugar, and dehydration

Other General Warnings

• You have diarrhea or a history of bowel problems.
• You have heart problems, a recent heart attack, unstable angina, an abnormal heart rhythm, or long QT syndrome.
• You have low blood salts (potassium, magnesium, phosphate), which can worsen heart rhythm problems.
• You have bleeding problems or low platelet counts.
• You have an infection.
• You have liver problems. The starting dose is reduced in mild or moderate liver impairment, and you should avoid it in severe liver impairment.
• You have severe kidney disease.
• You are pregnant, planning to become pregnant, or breastfeeding.
• You plan to have children in the future as the medicine can impact fertility in both men and women.

• Take Ixapana 10mg capsule by mouth exactly as prescribed by your doctor. Do not open, crush, or chew it.
• Do not change your dose or stop taking Ixapana 10mg capsule unless your doctor tells you to.
• Avoid star fruit, pomegranate or pomegranate juice, and grapefruit or grapefruit juice while taking this medicine.

• Store Ixapana 10mg capsule at 20°C to 25°C (68°F to 77°F). Keep the blister pack in the original carton to protect it from light.
• Keep Ixapana 10mg capsule and all medicines out of the reach of children.
• Ixapana 10mg capsule is a cytotoxic (cell-killing) medicine. Do not open, crush, or chew the capsules. Avoid contact with skin, eyes, or mucous membranes.
• If you come into contact, wash your skin thoroughly with soap and water or flush your eyes with water.
• Follow your pharmacist's or doctor's instructions for disposal of unused capsules.

• Keep anti-diarrheal medicine at home before you start treatment, after discussing it with your doctor. Contact your doctor at the first sign of diarrhea, persistent vomiting, or dehydration.
• Regular blood tests (blood counts, salts, and liver tests) and heart tracings (ECG) are needed before and during treatment.
• Report chest pain, palpitations, lightheadedness, fainting, or shortness of breath immediately.
• Report any bleeding, black stools, pink or brown urine, or unusual bruising immediately. Bleeding may take longer than usual to stop.
• Contact your doctor immediately if you develop a fever, chills, cough, or other signs of infection.
• Do not take laxatives or stool softeners without asking your doctor.
• Avoid star fruit, pomegranate, and grapefruit, including their juices.

Overdose

Missed a Dose

Interactions with other medicines

• Strong CYP3A inhibitors (such as ketoconazole, itraconazole, voriconazole, posaconazole, clarithromycin, ritonavir, lopinavir/ritonavir, indinavir, nelfinavir, saquinavir, boceprevir, telaprevir, telithromycin, nefazodone, and conivaptan) raise panobinostat levels.
• Strong CYP3A inducers may lower panobinostat levels and should be avoided.
• Ixapana 10mg capsule can raise levels of medicines processed by CYP2D6. Avoid sensitive CYP2D6 medicines such as atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine, and venlafaxine, and CYP2D6 medicines with a narrow safety margin such as thioridazine and pimozide. If you can't avoid using them together, your doctor will monitor you closely.
• Anti-arrhythmic medicines (such as amiodarone, disopyramide, procainamide, quinidine, and sotalol) and other medicines that prolong the QT interval (such as chloroquine, halofantrine, clarithromycin, methadone, moxifloxacin, bepridil, and pimozide) are not recommended with Ixapana 10mg capsule.
• Anti-nausea medicines with a known QT risk, such as ondansetron, can be used only with frequent heart tracing (ECG) monitoring.
• Stool softeners and laxatives may worsen diarrhea. Talk to your doctor before using them.
• Inform your doctor about all prescription medicines, over-the-counter medicines, vitamins, supplements, and herbal products you are taking.
• Interactions with food
• You can take Ixapana 10 mg capsule with or without food. Swallow the capsule whole with water.