Actilyse 50mg Inj 50ml
By BOEHRINGER INGELHEIM
50ml Injection in Vial
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Actilyse injection contains a medicine called alteplase. The injection contains a solution that can be used as an injection or for an infusion. It is used for treatment of heart attacks, stroke or blood vessel blockage in the lungs....
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|Contains||Alteplase(Recombinant Tissue Plasminogen Activator)|
|Uses||Heart attacks, blood clots in lung arteries|
|Side effects||Bleeding at injection site, chest pain, low blood pressure, heart attack, bleeding|
Check more medicines with composition as Alteplase(Recombinant Tissue Plasminogen Activator)
Uses of Actilyse 50mg Inj 50ml
- Heart attack
- Pulmonary embolism (blood clot in arteries of the lungs)
Contraindications of Actilyse 50mg Inj 50ml
- Known hypersensitivity to alteplase, gentamicin or other contents of injection
- Recent heart massage externally or puncture of blood vessel
- Patients taking anticoagulants
- Surgery or trauma experienced in past 10 days
- Bacterial infection of heart
- Recent gastric disease like ulcer
- History of stroke and head trauma together
- History of stroke and diabetes
- Present or past bleeding disorder in last 6 months
- Heparin given 48 hours before
- Low platelet count
- history of central nervous system damage
- Severe high blood pressure
- History of or suspected brain bleeds
- Aneurysms in artery, or malformation
- Abnormal tissue growth
- Recent stroke attack
- Serious liver issues
- Pancreas inflammation
- Seizure at onset of stroke
- Very low or very high blood sugar
- Very high or low blood pressure
- In children and adolescents below 18 years of age
Side effects of Actilyse 50mg Inj 50ml
- Gastric ulcers or bleeding
- Low blood pressure
- Heart problems
- Lung congestion
Precautions and Warnings of Actilyse 50mg Inj 50ml
Is taking the Actilyse injection safe during pregnancy?
It is not clear if Actilyse is completely safe in pregnant women. Hence, the benefit must be greater than the potential harm if this injection needs to be used.
Is it okay to take the Actilyse injection when I'm breastfeeding?
It is not known if alteplase passes into the breast milk. The doctor should decide based on the need of the patient and the risk.
Can I drive after taking the Actilyse injection tablet?
You should ask the doctor if you will be able to drive properly after taking this injection.
Can I consume alcohol after taking the Actilyse injection tablet?
Consult the doctor regarding safety of consuming alcohol after Actilyse injection.
Other General Warnings
Talk to your doctor if
- You have allergy to alteplase
- You have a different disease and are being treated for it
- You suffer from heart conditions or bleeding disorders
- You have had a surgery, stroke or any other trauma experience
- You have issues with the liver or pancreas
- You have a tumour or an unidentified cell growth
Mode of Action of Actilyse 50mg Inj 50ml
How Does It Work?
The alteplase present in this injection is a protein. It acts by dissolving clots that have formed in blood vessels and the blood supply is restored.
Directions for Use of Actilyse 50mg Inj 50ml
- This injection should only be given by doctor experienced with similar treatment and facilities to monitor the patient
- The dosage and frequency will be determined by the doctor
Interactions of Actilyse 50mg Inj 50ml
Interactions with other medicines
- Medicines that affect blood clotting or platelet function if given with Actilyse can increase risk of bleeding
- Concomitant use with blood pressure medications can increase the risk of an allergy reaction to Actilyse
Storage and disposal of Actilyse 50mg Inj 50ml
Store in dry place away from light. Store at room temperature below 25 °C. After reconstitution, it can remain stable for up to 24 hours at 2-8°C. It should, however, be used immediately after reconstitution....
Dosage of Actilyse 50mg Inj 50ml
Overdose with this injection is usually treated with fresh plasma administration to the patient.
Missed a Dose
Since Actilyse injection is used in critical conditions or emergencies, there are no chances of missed dosage.
Frequently Asked Questions (FAQs)
Q: Will this medication affect my fertility?
A: Actilyse has not been associated with any fertility issues and a doctor must be consulted for the best advice in this regard.
Q: What if I do not feel well after taking this injection?
A: You must always talk to the doctor if you are experiencing any discomfort or uneasiness, even if the symptoms are mild. The doctor should be aware of your condition.
Q: Why is it not safe for me to take the injection if I have liver problems?
A: The liver is a major organ that converts the medicine alteplase into products that can be excreted out of the body. Hence, if the liver is not working properly, it can cause toxicity of alteplase and produce harmful effects.
Q: What should I avoid after taking the Actilyse injection?
A: You should consult with the doctor regarding any special dietary, or other health-related precautions you need to take after this medicine has been given.
- ACTILYSE. [Internet]. Boehringer-ingelheim.in. 2022 [cited 15 March 2022]. Available from: https://www.boehringer-ingelheim.in/sites/in/files/files/proposed_pi_dated_6th_may_2019.pdf
- Actilyse - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2022 [cited 15 March 2022]. Available from: https://www.medicines.org.uk/emc/medicine/308#gref
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