Glimisave M2 Tablet

• If you are allergic to metformin, glimepiride or any of the ingredients of this medicine.
• If you are pregnant or breastfeeding.
• If you have serious kidney failure or liver failure.
• If you have any metabolic acidosis (too much acid in the body fluids) like lactic acidosis, diabetic ketoacidosis or diabetic pre-coma.
• If you have dehydration, severe infections, shock and injections containing iodine.
• If you have had heart or lung failure, a recent incidence of heart attack and shock.
• If you are an alcoholic.

• Metabolic disorders - weight gain, low blood sugar level which can cause headache, sweating, nausea, wet skin, anxiety and restlessness.
• Stomach disorders - vomiting, nausea, diarrhoea, stomach pain, loss of taste sensation, metallic taste and stomach discomfort (pressure and fullness).
• Heart disorders - High blood pressure, irregular heart rhythm, chest pain (arrhythmias).
• Skin disorders - Allergic skin reactions like rashes, itching, red bumps on the skin and sometimes hair loss, in case of progressive skin allergy, inform the doctor immediately, it might lead to shock.
• Eye disorders - Temporary visual disturbances
• Blood disorders - Changes in blood cell count, anaemia
• Others - Difficulty in breathing, decrease in vitamin B12 levels alter brain function and light sensitivity.

Other General Warnings

• You experience extreme hunger, headache, nausea, vomiting, sleepiness, restlessness, aggression, reduced alertness, confusion, shakiness or dizziness. These could be signs of low blood sugar. If you have any of these, immediately have sugar or sweet juice Inform your doctor as you may need a change in your medicine's dose.
• You are experiencing pins-and-needles sensation, numbness and weakness.
• You are going to have a diagnostic imaging test that involves an injection of iodine.
• You have dehydration due to diarrhoea, vomiting or limited fluid intake.
• You have suffered through trauma.
• You have to undergo surgery in the near future.
• You have serious kidney and liver problems.
• You have a thyroid disorder.
• You are overweight (specific diet restriction may be suggested).

• Store it at room temperature in a dry place.
• Protect it from moisture.
• Keep it out of the reach of children.

Overdose

• Overdose of this medicine may lead to severe hypoglycemia and lactic acidosis (Excessive lactic acid build-up) & (low blood sugar).
• This can result in headache, nausea, vomiting, sleep disturbances, restlessness, impaired alertness and reactions, depression, confusion, dizziness, etc.
• If you experience these, immediately take glucose or juice or sugar-containing products (Sugar candy).
• Contact your doctor immediately or visit the nearest hospital as you may require close monitoring for the next few hours.

Missed a Dose

• A missed dose may lead to high blood sugar levels, which includes symptoms like feeling thirsty, excessive urination, loss of appetite, drowsiness, a fruity smell from breath, etc.
• If you missed any dose of medicine, take it as soon as you remember it.
• If it's time for your next dose, then skip the missed dose and continue with your regular dosing schedule.
• Do not take a double dose of medicine to compensate for the missed one.

How Does It Work?

• This combination is known to control blood sugar to a greater extent than metformin or glimepiride alone. Glimiperide lowers the blood sugar level increasing release of insulin hormone from the pancreas.
• Insulin moves sugar (glucose) from the blood into the cells.
• Metformin decreases the absorption in the intestine and production of sugar by the liver.
• Both of these components are known to increase the insulin sensitivity of the body (allows the cells of the body to use blood glucose more effectively, reducing blood sugar).

Interactions with other medicines

• You may have symptoms of low blood sugar if you are taking other medicines for diabetes like Insulin, Pioglitazone, medicines for high blood pressure (ACE inhibitors like Captopril), Steroids, Chloramphenicol, Fenfluramine, Fenyramidol, medicine to lower blood cholesterol (fibrates), medicine to treat depression (Fluoxetine), medicine to treat blood clotting like Coumarins, Cyclophosphamide, Miconazole, Probenecid, antibiotics like Clarithromycin, Doxycycline, Ofloxacin, etc.
• You may have symptoms of high blood sugar if you are taking oral contraceptives, Acetazolamide, water pill, Phenytoin, Rifampicin, medicines for constipation, Phenytoin, Rifampicin and medicines for thyroid disorders.
• Medicines like anti-allergic (ranitidine), clonidine, reserpine and medicines used to treat high blood pressure like atenolol can alter the way this medicine works and may block your body's response to low blood sugar. This can lead to dangerously low levels of blood sugar.
• Medicines like Diclofenac, Ibuprofen, Water pill, Enalapril may affect your kidney functions if taken along with this medicine.
• Medicines used to treat thyroid can affect the way this medicine works.