Vitamin B6 / Pyridoxine
Description
Vitamin B6 (Pyridoxine) is an essential water-soluble vitamin involved in numer
ous metabolic processes, particularly the metabolism of proteins, carbohydrates, and fats. It plays a crucial role in the formation of neurotransmitters such as serotonin, dopamine, and GABA, which support normal brain function, mood regulation, and healthy sleep patterns. Vitamin B6 is also necessary for the production of haemoglobin, the component of red blood cells that carries oxygen throughout the body, and it supports proper immune function by aiding in antibody formation. Deficiency of Vitamin B6 can lead to symptoms such as irritability, depression, peripheral nerve problems, anaemia, seizures (especially in infants), and skin changes like dermatitis or cracks around the mouth. It may be prescribed for conditions such as anaemia due to deficiency, nausea and vomiting in pregnancy, certain nerve-related disorders, homocystinuria, and to support overall metabolic health. It should be taken under medical supervision, as excessive or long-term high doses may cause nerve damage or sensory disturbances.
Uses
Contraindications
When should one not use Vitamin B6 / Pyridoxine
Side effects
Common side effects of this drug are:
- Nausea or stomach discomfort
- Headache
- Sleepiness or drowsiness
- Increased sensitivity to sunlight
- Mild skin reactions such as rash or itching
Precautions and Warnings
Other General Warnings
- You are pregnant, breastfeeding, or have any existing medical condition like diabetes, hypertension, kidney or liver problem, etc., be sure to consult your doctor.
- You are on other medications, supplements or following any complementary or integrative health approaches.
- You are going to undergo any surgery or operation.
- You should avoid consuming too much alcohol.
- Vitamin/Mineral supplements are intended to supplement the diets of some people and should not be a substitute for a well-balanced, varied diet and a healthy lifestyle.
Mode of Action
How Does It Work?
- It is an essential vitamin and is a crucial component for various reactions.
- It helps to improve metabolism along with the maintenance of the nervous and immune system.
Content Details
Ravindra Ghongade
B. Pharm
Dr. Nikita Toshi
BDS (Bachelor of Dental Surgery), WHO FIDES member
Frequently Asked Questions (FAQs)
Q: What is Vitamin B6 and why is it important?
Q: What conditions can Vitamin B6 help treat?
- Vitamin B6 is used to treat deficiency, anaemia caused by low B6 levels, neuropathy, homocystinuria, certain metabolic disorders, and symptoms like nausea and vomiting in pregnancy (when prescribed). It also supports normal nerve and brain health....
Q: What are the signs of Vitamin B6 deficiency?
- Deficiency may cause irritability, depression, confusion, weakness, cracked lips, dermatitis, numbness or tingling of hands and feet, anaemia, and in severe cases, seizures (especially in infants).
Q: Can I get enough Vitamin B6 from food?
- Yes. Foods rich in Vitamin B6 include fish, poultry, eggs, bananas, nuts, whole grains, potatoes, and fortified cereals. However, supplements may be needed if dietary intake is insufficient or if your body requires more due to specific medical conditions....
Q: Is Vitamin B6 safe during pregnancy and breastfeeding?
- Vitamin B6 is generally safe and often recommended for pregnancy-related nausea, but only in doses prescribed by a doctor. Excessive use should be avoided, especially without medical supervision.
References
- Pyridoxine - MedlinePlus [Internet]. Medlineplus.gov. 2022 [cited 24 Nov 2025]
- Vitamin B6 - MedlinePlus [Internet]. Medlineplus.gov. 2022 [cited 24 Nov 2025]
- Vitamin B6 [Internet]. Ods.od.nih.gov. 2022 [cited 24 Nov 2025]
- Abosamak NER, Gupta V. Vitamin B6 (Pyridoxine) [Updated 2023 Aug 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. [cited 24 Nov 2025].
- ScienceDirect. Vitamin B6. ScienceDirect. Accessed [cited 24 Nov 2025].
