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Tapentadol

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Molecule Summary

Uses
Management of severe long-term pain that can be only managed with opioid analgesics adequately in adults
Therapy
Analgesic For Severe Pain
Side Effects
Nausea, Vomiting, Dizziness, Drowsiness, Headache, Decreased appetite, Anxiety, Confusion, Indigestion, Feelings of weakness, Fatigue
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Molecule Description

Tapentadol is a potent analgesic (painkiller) recommended in adults suffering from moderate to severe acute pain that can be adequately treated only with an opioid painkiller.

Uses

  • Tapentadol is used in cases of severe long-term pain in adults that can be managed only with opioid analgesics.

Contraindications

When should one not use Tapentadol

  • If you have a known allergy to tapentadol or any other substances used in this product.
  • If you have breathing problems like asthma or slow or shallow breathing, and respiratory depression.
  • If you have hypercapnia (increased carbon dioxide in the blood).
  • If you have any condition affecting the digestive tract like gut paralysis.
  • If you have acute poisoning due to excessive consumption of alcohol, sleeping pills, pain medications or psychotropic medicines affecting mood and emotions

Side effects

Common side effects of this drug are:

  • Nausea
  • Vomiting
  • Dizziness
  • Drowsiness
  • Headache
  • Decreased appetite
  • Anxiety
  • Confusion
  • Indigestion
  • Feelings of weakness
  • Fatigue

Precautions and Warnings

Pregnancy

Pregnancy

Please consult a doctor before taking the medication if you are pregnant. Tapentadol, if used over prolonged periods during pregnancy, may cause withdrawal symptoms in the newborn baby.

Breast Feeding

Breast Feeding

Tapentadol is passed into the breast milk. It is recommended to consult a physician prior to breastfeeding when taking this medication.

Driving

Driving

Tapentadol may impair your reactions and cause drowsiness, dizziness, or blurred vision. It is recommended to consult a physician before driving while using this medication.

Alcohol

Alcohol

Avoid drinking alcohol with Tapentadol as it may cause an increase in certain side effects such as drowsiness.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • If you have problems with breathing, such as shallow or slow breathing.
  • If you have any condition affecting the liver, pancreas, gallbladder or bile ducts, including pancreatitis.
  • If you have a condition that increases pressure in the brain or have issues with consciousness.
  • If you have or have had a brain tumour.
  • If you have suffered a head injury.
  • If you have kidney disease.

Mode of Action

How Does It Work?

Tapentadol is an opioid analgesic. It acts on the natural chemical substances released in the brain for pain perception. Taking Tapentadol temporarily changes the way the brain and the nervous system react to pain.

Interactions

Interactions with other medicines

  • Medicines that may cause convulsions (fits), such as antidepressants or antipsychotics (mood stabilizers)
  • Medicines used for sedation (benzodiazepines) or certain sleeping pills or tranquillizers (barbiturates), or pain relievers such as opioids, morphine, and codeine (also used as cough medicine)
  • Medicines that affect serotonin levels (certain medicines to treat depression)
  • Concomitant use with strong enzyme inducers (rifampicin, phenobarbital, St John's Wort) and enzyme inhibitors (ketoconazole, fluconazole, meclofenamic acid); these medicines affect the activity of certain enzymes required for processing and eliminating the medication from the body.
  • Concomitant use (or used in the last 14 days) of Monoamine Oxidase Inhibitors (MAOIs) for depression.

Dosage

Overdose

Vomiting, pin-point pupils, fast heartbeat, decreased blood pressure, seizures, slow or weak breathing or no breathing, and unconsciousness are overdose symptoms. Get in touch with your doctor immediately.

Missed a Dose

If you have missed a dose of Tapentadol, your pain may return. Continue as per your regular schedule, and do not take a double dose to make up for the missed dose.

Frequently Asked Questions (FAQs)

Yes. Tapentadol can be used in older adults, usually without the need for dose adjustment. However, some patients of this age group may exhibit a delay in processing and eliminating the medicine from the body, in which case the doctor may recommend a change in dose.

Tapentadol is not recommended in patients with severe liver and kidney problems. Please inform the doctor regarding any underlying liver and kidney disease and use the medication after a medical consultation.

Tapentadol is not recommended for use in children below 18 years.

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