Repaglinide

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Molecule Description

Repaglinide is an oral anti-diabetic medicine which helps your pancreas to produce more insulin and thereby lower your blood sugar (glucose) after meals.

Uses

It is used to treat persons with Type II diabetes to lower blood sugar levels after a meal who cannot control by diet restrictions and exercise alone
It can be used as a single medicine or in combination with other anti-diabetic medicines such as Metformin

Contraindications

When should one not use Repaglinide

Do not take this medicine if you have Type 1 diabetes, liver disease, kidney disease and complication of diabetes in which there is excess acids in the body (diabetic ketoacidosis)
Do not take if you are allergic to Repaglinide or any ingredient of this medicine

Side effects

Common side effects of this drug are:

Loose stools
Low blood glucose level
Stomach pain

Precautions and Warnings

Pregnancy

Repaglinide use in pregnant women has not identified a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes. Yet, it is not recommended for pregnant women.

Breast Feeding

It is not secreted into breast milk. But still, do not breastfeed while you are taking Repaglinide without consulting your doctor. Because this medicine has the potential to cause low blood sugar in breastfed infants, Repaglinide is not recommended while breastfeeding.

Driving

You may experience blurred vision, dizziness or drowsiness due to extremely low or high blood sugar while on this medication. So it is advised not to drive or operate any machines.

Alcohol

You are advised for a limited intake of alcohol while taking this medicine because it can increase the risk of developing low blood sugar. Alcohol may affect blood glucose levels in a person with diabetes and interferes with the activity of Repaglinide.

Other General Warnings

Talk to your doctor if

You have liver problems
You have kidney problems
You are about to have major surgery
You have recently suffered a severe illness or infection
You are under 18 or over 75 years of age

Mode of Action

How Does It Work?

Repaglinide stimulates the release of insulin from the pancreas and lowers blood glucose.

Interactions

Interactions with other medicines

Repaglinide may interact with medicines that are used to control high blood pressure, Barbiturates, Carbamazepine, Chlorpromazine, Olanzapine, Clarithromycin, Erythromycin, Aspirin, Clopidogrel, Cyclosporine, Gemfibrozil, Ketoconazole, Itraconazole, Rifamycins and Rifabutin.

Interactions with food items

Avoid taking this medicine along with grapefruit or grapefruit juice.

Dietary Restrictions

You are advised to take:
Non-starchy vegetables, tomatoes, blueberries and other berries, oranges and other citrus and fishes with omega-3 fatty acids, walnuts, flax seeds and other nuts and seeds, beans
You should avoid:
Trans fats
White bread
Pasta and rice
Fruit-flavored yogurt
Sweetened breakfast cereals
Flavored coffee drinks
Honey, etc.

Dosage

Overdose

If you happen to take too many tablets by mistake, then blood sugar may become too low leading to symptoms of cold sweats, increase in heart rate, tremors and anxiety. In such cases, consult your physician as soon as possible.

Missed a Dose

If you missed a dose, take the next dose as usual but do not double the dose. Increasing the dosage can be dangerous as you may experience low blood sugar levels, which can be serious.

Frequently Asked Questions (FAQs)

Repaglinide should be used with caution in elderly persons because they may be more sensitive to it. Repaglinide may cause changes in your blood sugar levels. One should be aware of the symptoms of high blood sugar (hyperglycemia) or low blood sugar (hypoglycemia) episodes and be prepared to treat them.

You should always carry some glucose, sugary food or fruit juice with you in case you experience symptoms of low blood glucose level (hypoglycemia) such as cold sweats, increase in heart rate, tremors and anxiety.

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