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Phenylephrine+Pholcodiene+Promethazine

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Molecule Summary

Uses
Dry cough, common cold, nausea and vomiting, motion sickness, allergy, runny nose, blocked nose, blocked ear, hives or rashes
Therapy
Cough Cold Preparation
Side Effects
dizziness, sleepiness, fatigue, dry mouth, increased heart rate, constipation.
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Molecule Description

Phenylephrine+Pholcodiene+Promethazine is a medicine primarily used in the treatment of allergic or dry cough and common cold in children. It contains promethazine, pholcodine, and phenylephrine as its active ingredients.

Uses

  • Phenylephrine+Pholcodiene+Promethazine is used in,
  • Treatment of dry cough
  • Treatment of common cold
  • Treatment of nausea and vomiting
  • Treatment of motion sickness
  • Treatment of allergies and allergic rhinitis (runny nose)
  • Treatment of hives and rashes
  • Treatment of blocked nose
  • Treatment of blocked ear

Contraindications

When should one not use Phenylephrine+Pholcodiene+Promethazine

  • If you have any heart condition
  • If you suffer from respiratory issues like asthma
  • If you have constipation
  • If you have diabetes
  • If you have calcium deficiency
  • If you have potassium deficiency
  • If you have been diagnosed with any liver disease
  • If you have been diagnosed with parkinsonism (involuntary muscle spasms, unclear thoughts)
  • If you have chronic obstructive pulmonary disease(COPD)
  • If you have glaucoma (increased intra-eye pressure due to blockage caused by defects in eye structure)
  • If you have been diagnosed with thyroid problems

Side effects

Common side effects of this drug are:

  • Dizziness
  • Sleepiness
  • Constipation
  • Dry mouth
  • Confusion
  • Nausea
  • Vomiting
  • Increased heart rate
  • Increased blood pressure

Precautions and Warnings

Pregnancy

Pregnancy

There is insufficient data to establish the safety of Phenylephrine+Pholcodiene+Promethazine during pregnancy. Pregnant women might experience mild side effects while taking Phenylephrine+Pholcodiene+Promethazine. Consult your physician if you are pregnant or planning a pregnancy while taking this medication.

Breast Feeding

Breast Feeding

Breastfeeding mothers might experience mild side effects from taking Phenylephrine+Pholcodiene+Promethazine. Talk to your physician if you plan to take this medication while breastfeeding.

Driving

Driving

Phenylephrine+Pholcodiene+Promethazine may cause drowsiness, sleepiness, and confusion. Therefore, driving or the use of heavy machinery is to be avoided while taking this medication.

Alcohol

Alcohol

There is not much data to support the adverse reactions between alcohol and Phenylephrine+Pholcodiene+Promethazine. There may be a possibility that Phenylephrine+Pholcodiene+Promethazine may increase the side-effects of alcohol like drowsiness, sleepiness, and blurry vision. Therefore, it can be unsafe to consume alcohol while taking Phenylephrine+Pholcodiene+Promethazine.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You/your child experiences any allergy after taking Phenylephrine+Pholcodiene+Promethazine like rashes, hives or swelling on the face.
  • You want to increase/decrease the dose of the medication.
  • You experience side-effects that are too severe and do not seem to go away.
  • You want to stop taking Phenylephrine+Pholcodiene+Promethazine.
  • You have missed any dose/doses of Phenylephrine+Pholcodiene+Promethazine.
  • You conceive during the course of Phenylephrine+Pholcodiene+Promethazine.

Mode of Action

How Does It Work?

Phenylephrine+Pholcodiene+Promethazine contains a combination of 3 active ingredients: promethazine, pholcodine, and phenylephrine.

Interactions

Interactions with other medicines

  • To avoid side effects associated with medicine interaction, it is important to inform the doctor about all medicines and health supplements you are currently taking.
  • Phenylephrine+Pholcodiene+Promethazine should be given with caution/ not given along with the following medications. Doses of Phenylephrine+Pholcodiene+Promethazine have to be adjusted in cases of increase or decrease of efficacy.
  • Haloperidol, clozapine, chlorpromazine (antipsychotic for schizophrenia, Tourette's syndrome) - can cause increased muscle stiffness and difficulty in talking due to combined severe anti-dopamine effect.
  • Cisapride (medication used in the treatment of heartburn) - decreases efficacy.
  • Metoclopramide (medicine used in the treatment of gastroesophageal reflux, nausea) - causes increased convulsions and uncontrolled muscle spasms.
  • Quinidine (medication to regulate heartbeat) - blurry vision, tremor, confused thoughts.
  • Doxepin (antianxiety) - increases the effect of Phenylephrine+Pholcodiene+Promethazine, and thus is harmful.
  • Amitriptyline, amoxapine, citalopram (antidepressants) - increase the risk of irregular heartbeat, which can be fatal.

Interactions with food items

  • Phenylephrine+Pholcodiene+Promethazine does not show any adverse effects with any food. A regular diet can be followed unless advised otherwise by the physician.
  • No major studies have been done on the use of alcohol while on Phenylephrine+Pholcodiene+Promethazine, but it carries the risk of increased side effects like sleepiness, dizziness, and confusion.

Dosage

Overdose

If you think you have taken too much of Phenylephrine+Pholcodiene+Promethazine, seek emergency medical help or go to the nearest hospital immediately.

Missed a Dose

If you miss a dose of Phenylephrine+Pholcodiene+Promethazine, take it as soon as you can. If the gap is too long or the next dose is only a few hours away, skip the dose you have missed and continue with the regular schedule.

Frequently Asked Questions (FAQs)

Yes, constipation is a very common side effect of Phenylephrine+Pholcodiene+Promethazine. Consuming an adequate amount of water throughout the day and being physically active may help counter this side effect.

No. Phenylephrine+Pholcodiene+Promethazine has sedative effects, but it should not be used to induce sleep in children as it may carry the risk of severe respiratory depression causing breathing difficulties.

Phenylephrine+Pholcodiene+Promethazine can be addictive when taken in large doses for prolonged periods. Medications formulated for children are rarely addictive when given in proper doses and for short periods.

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