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Pertuzumab

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Molecule Summary

Uses
Breast cancer
Therapy
Anti-Neoplastic
Side Effects
Diarrhoea, nausea, vomiting, hair loss, rash, sore mouth, fever, fatigue, weakness and low white blood cell count (neutropenia)
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Molecule Description

Pertuzumab is an anticancer medication used to treat a specific type of breast cancer (HER2-positive) in conjunction with other chemotherapy drugs. Common side effects of this medication include hair loss, diarrhoea, nausea, and fatigue. This medication may reduce the number of blood cells, specifically decreasing white blood cells, which can increase susceptibility to infections. Regular blood tests are required to monitor your blood cells, as well as to check your heart, liver, and kidneys. Many other medications can affect or be affected by this treatment, so inform your healthcare team about all medications you are using. This medication is not recommended during pregnancy or while breastfeeding. Women who could become pregnant must use effective contraception during treatment to prevent pregnancy. Men should ask their doctor whether they also need to use contraception. Please discuss all medications you are currently taking, including supplements and herbs, with your doctor before starting Pertuzumab. Additionally, it is important to inform your doctor if you have a history of heart problems or have previously undergone chemotherapy.

Uses

Pertuzumab is an anticancer medication used to treat a type of breast cancer known as HER2-positive breast cancer in combination with other chemotherapy agents.

Contraindications

When should one not use Pertuzumab

If you have any allergy to pertuzumab or any other ingredient in this medicine.

Side effects

Common side effects of this drug are:

  • Nasopharyngitis
  • Upper respiratory tract infection
  • Neutropenia
  • Diarrhoea
  • Vomiting
  • Stomatitis
  • Nausea
  • Alopecia
  • Rash
  • Pyrexia (Fever)
  • Fatigue
  • Asthenia (Weakness)

Precautions and Warnings

Pregnancy

Pregnancy

Pertuzumab is not advisable during pregnancy and for women of childbearing potential who are not using contraception. Ask your doctor whether your partner also needs to use contraception.

Breast Feeding

Breast Feeding

Pertuzumab may be excreted in breast milk; therefore, a decision should be made regarding whether to discontinue breastfeeding or to halt treatment, considering the benefits of breastfeeding for the child and the advantages of Pertuzumab therapy for the woman.

Driving

Driving

Pertuzumab has a minor impact on driving or operating machines. Dizziness may occur during treatment, and patients with infusion reactions should avoid driving or using machines until symptoms improve.

Alcohol

Alcohol

No known interactions with alcohol.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have kidney disease or have undergone a kidney transplant.
  • You have liver disease or a history of liver issues.
  • You have a history of heart disease, including heart failure or diminished heart function.
  • You are experiencing symptoms such as shortness of breath, swelling in the legs, or a rapid heartbeat during treatment.
  • You have suffered severe allergic reactions to medications in the past.
  • You are pregnant, planning to conceive, or breastfeeding.
  • You experience severe diarrhoea, dehydration, or unusual fatigue during treatment.
  • You develop a fever, chills, or other signs of infection.
  • You notice any unusual swelling, rash, or hives after an infusion.
  • You have a low white blood cell count or have experienced febrile neutropenia previously.
  • You experience sudden changes in vision or severe headaches during treatment.
  • You are taking other medications, including over-the-counter drugs or supplements, as they may interact with Pertuzumab.

Mode of Action

How Does It Work?

Pertuzumab specifically targets a protein known as HER2, found on the surface of certain breast cancer cells. HER2 plays a crucial role in promoting the growth and division of these cells. Pertuzumab binds to a distinct part of the HER2 protein, impeding its proper function, which can help inhibit the growth and spread of cancer cells.

Dosage

Overdose

Your doctor or nurse will give Pertuzumab. Therefore, the chances of overdose are very rare. If you experience the symptoms right after receiving the medicine, seek medical help.

Missed a Dose

Your doctor or nurse will carefully monitor and schedule your medicine, making it unlikely for a dose to be missed. However, if you suspect a dose might have been overlooked, let them know immediately.

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