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Molecule Description

Perindopril is an Angiotensin Converting Enzyme inhibitors (ACE inhibitors). It is used for controlling high blood pressure. By lowering the blood pressure, it helps to reduce the risk of stroke and heart attack.
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Uses of Perindopril

  • High blood pressure (hypertension)
  • Congestive Heart failure (a condition when the heart is unable to pump enough blood to meet the body's needs)
  • Prevents heart attack (a situation where the blood supply to the heart is reduced or blocked) and stroke
  • Preserves kidney function and retina in persons with diabetes
  • Reduce proteinuria in diabetic and non-diabetic renal disease
  • Scleroderma crisis

Contraindications of Perindopril

When should one not use Perindopril

  • Do not take it if you are allergic to Perindopril
  • Do not take this medicine in pregnancy (third trimester)
  • Do not take if severe skin rashes with previous ACE inhibitor treatment
  • Do not take if you have diabetes or impaired kidney function
  • Do not take if you are treated with a blood pressure lowering medicine containing Aliskiren

Side effects of Perindopril

Common side effects of this drug are:

  • Dry cough
  • Swelling of the face, tongue or throat (angioedema)
  • Taste disturbances
  • Low blood pressure (hypotension)
  • Increases Serum Potassium in the blood
  • Raised liver enzymes
  • Headache and dizziness
  • Breathing difficulty, wheezing
  • Kidney impairment

Precautions and Warnings of Perindopril


Can I take Perindopril during pregnancy?
Perindopril is not recommended in early pregnancy and should not be taken in women more than three months pregnant, as it may cause serious harm to the unborn baby (fetus).

Breast Feeding

Can I take Perindopril while breastfeeding?
Perindopril is not recommended for breastfeeding mothers. However, no significant information is available.


Can I drive if I have consumed Perindopril?
This medicine may cause dizziness or fatigue due to low blood pressure in some persons. This may affect your driving ability. Do not drive unless you are feeling well.


Can I consume alcohol with Perindopril?
You should avoid or should take a limited amount of alcoholic beverages during this medication, however no significant information available.

Other General Warnings

Talk to your doctor if
  • You have kidney disease
  • Perindopril should be used with precaution in persons with kidney disease. Dose adjustment is needed in such patients.
  • If you have liver disease, inform your doctor if you develop any signs and symptoms of jaundice or have raised liver enzymes while taking this medicine. In such cases, dose adjustment of this medicine may be needed
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Mode of Action of Perindopril

How Does It Work?

Perindopril inhibits Angiotensin Converting Enzyme (ACE). So, it decreases the activity of the Renin Angiotensin Aldosterone System (RAAS) and prevent the conversion of Angiotensin I to Angiotensin II. It reduces and dilates the blood vessels so that blood flows more smoothly and the heart can pump enough blood more efficiently to meet the body's needs.
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Interactions of Perindopril

Interactions with other medicines

  • Analgesics such as Ibuprofen, Indomethacin can risk kidney problem
  • Water pills (Diuretics) can lower down the blood pressure
  • Mood stabilizer (Lithium)
  • Immunosuppressant medicines such as Cyclosporine
  • Potassium supplements or medications that raise Serum Potassium such as Spironolactone, Amiloride

Interactions with food items

You should avoid potassium supplements as they interact with Perindopril causing an increased risk of side effects. Avoid alcohol along with this medicine. Avoid excess salt, packed food, pickles, etc.
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Dietary Restrictions of Perindopril

No information is available on dietary restrictions while you are taking Perindopril, consult your doctor or pharmacist for further details.

Dosage of Perindopril


Overdose of this medicine may cause sudden kidney failure, increased heart rate (tachycardia), low blood pressure (hypotension), dizziness, anxiety, and cough, increased levels of potassium in the blood (hyperkalemia).
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Missed a Dose

If you missed a dose, take the next dose as soon as you remember. Do not take a double dose if you have missed the dose.

Content Details


Dr. Arpit Verma

MBBS, MD (Pharmacology)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What are the precautions to take before starting this treatment?

A: While taking Perindopril, particularly during the first month of its use, preferably, it should be taken at bed time as it causes dizziness. Women should inform their doctor if they are pregnant, planning a pregnancy or are nursing mothers. You should give a history of liver or kidney disease, if any.

Q: At what time should I take medicine?

A: At the start, you should try to take it during bedtime because it may cause dizziness for the first few days.

Q: Can you take potassium supplements along with this medicine?

A: This medicine may increase the level of potassium in blood. So you should avoid taking potassium supplements and potassium-rich foods such as banana and broccoli.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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